Clinical Trials
Category Added in a WPeMatico Campaign
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Comparison of Liposomal Bupivacaine versus Bupivacaine in Superficial Parasternal Intercostal Plane Block for Cardiac Surgery with Median Sternotomy
CONCLUSIONS: Lip-BPVC initially increased inflammatory markers postoperatively, but levels were comparable to BPVC by 72 hours. It provided superior pain control and reduced opioid use compared to standard BPVC in CABG patients, with similar safety and recovery outcomes.
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Investigating the effectiveness and mechanism of Xinbao pill in micro vascular angina treatment
Coronary micro vascular dysfunction is attracting increasing attention, yet effective treatments remain inadequate. This study analysed the clinical efficacy and potential mechanisms of Xinbao pill in patients with microvascular angina (MVA). 200 MVA patients admitted from January 2020 to June 2021 were randomly divided into the control group (n = 100) and an observation group…
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The impact of refined nursing management on the diagnosis of early gastric cancer under ME-NBI
CONCLUSION: The application of refined nursing management combined with ME-NBI technology for the diagnosis of early gastric cancer can significantly improve patient compliance, gastric mucosal visibility, and gastric cancer detection rate, which is worthy of clinical promotion and application.
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Cryo-Induced Hypoalgesia: The Effects of an Acute Cryochamber Exposure on Pain Perception-A Randomised Controlled Cross-Over Trial
CONCLUSIONS: This study demonstrates that a three-minute cryochamber exposure induces robust hypoalgesia in healthy participants, as indicated by increased PPT, lasting up to 30 min but gradually declining over time.
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Efficacy of topical tacrolimus 0.03% ointment in combination with microneedling versus topical phenytoin 2% cream in combination with microneedling for the treatment of non-segmental facial vitiligo
CONCLUSION: Our results provide additional evidence for the potential positive role of phenytoin as a therapeutic option in patients with non segmental vitiligo. However, tacrolimus 0.03% ointment combined with microneedling was associated with a better response than phenytoin 2% cream combined with microneedling.
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Internet-based digital intervention to support the self-management of hypertension compared to usual care: results of the HALCYON randomized controlled trial
CONCLUSIONS: The present study shows first promising results of liebria’s effects on systolic blood pressure and social and work-related functioning. Future studies should aim to replicate effects in a larger sample to increase statistical power.
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Phase I Study of Subcutaneous Rituximab Hyaluronidase Combined With CHOP Chemotherapy for the Treatment of Diffuse Large B-Cell Lymphoma in Uganda
CONCLUSION: As demonstrated in other parts of the world, sqR together with CHOP was safe, well-tolerated, and efficacious among Ugandan patients with DLBCL. The very high OS rates are nearly double those of historical controls and comparable with outcomes expected in resource-rich settings. This study demonstrated the feasibility, safety, and efficacy of sqR-CHOP, increased the…
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Telehealth intervention involving the HEARTS Technical Package and the additional use of an activity monitor to increase physical activity level post-stroke: Protocol for a feasibility randomized controlled trial
BACKGROUND: Low physical activity level is a common risk factor for recurrent stroke. Feasibility studies show behavior change interventions can increase physical activity participation, but face barriers (e.g., home visits or internet access). Low-cost telehealth approaches, like telephone calls, may overcome these challenges. Another low-cost strategy involves motivational tools supporting «Behavioral Regulation,» such as physical…
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Reconstructive Therapy of Peri-Implantitis Following Non-Surgical Treatment: A Randomized Controlled Trial
CONCLUSIONS: The tested therapeutic modalities demonstrated equal disease resolution. Nevertheless, the marginal bone level gain was significantly greater for sites subjected to reconstructive surgical therapy (NCT05168891-This clinical trial was not registered prior to participant recruitment and randomization).
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After the program ends: HIV testing behavior among men who have sex when men after the conclusion of a program providing regular home delivery of HIV self-testing kits
Testing for HIV continues to play a key role in prevention, especially among at-risk populations such as gay, bisexual, and other men who have sex with men (MSM). Incorporating HIV self-testing (HIVST) into testing programs encourages more frequent screening and likely facilitates earlier diagnosis, but little is known about how testing behavior changes after self-testing…