Clinical Trials
Category Added in a WPeMatico Campaign
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Efficacy of an Intelligent and Integrated Older Adult Care Model on Quality of Life Among Home-Dwelling Older Adults: Randomized Controlled Trial
CONCLUSIONS: The personalized and integrated older adult care by the SMART system demonstrated significant efficacy in improving QOL, health self-management ability, and social support, while reducing instrumental activities of daily living disability among home-dwelling older adults.
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One-Day Online Cognitive Behavioral Therapy-Based Workshops for the Prevention of Postpartum Depression: A Randomized Controlled Trial
Background: Postpartum depression (PPD) affects up to 1 in 5 birthing parents and is associated with more future depressive episodes. We aimed to determine if PPD could be prevented with online 1-day cognitive behavioral therapy (CBT)-based workshops.
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Clinical Trial Notifications Triggered by Artificial Intelligence-Detected Cancer Progression: A Randomized Trial
CONCLUSIONS AND RELEVANCE: In this randomized trial, prompting academic medical oncologists with information about genomically matched therapeutic clinical trials for patients with tumor progression based on AI interpretation of imaging reports did not increase therapeutic trial enrollment. The findings suggest that future use of AI to optimize enrollment in cancer clinical trials should include tasks…
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Impact of the in-office bleaching gels pH on tooth sensitivity in combined bleaching techniques: a randomized clinical trial
CONCLUSION: Using a gel with neutral and stable pH during in-office bleaching reduces the risk and intensity of TS without compromising whitening efficacy.
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The Organic Halo Effect: Perceived Caloric Disparities in High- and Low-Calorie Foods and the Role of Nutrition Label Reading Frequency
BACKGROUND: This study examines the organic halo effect, specifically how organic labels influence perceptions of caloric content and consumption recommendations for high and low calorie food items. Previous research suggests that organic labels can create a perception of healthiness, but it is unclear how these perceptions vary with food calorie content.
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Efficacy of Hamstring Stretching, Ultrasound Therapy, and Pressure Pain Threshold for Masseter Muscle in TMJ Dysfunction Patients: A Randomized Controlled Trial
CONCLUSION: Hamstring stretching combined with ultrasound therapy and pressure pain threshold application was significantly more effective in reducing TMD-related pain and improving MVMO than pressure pain threshold and ultrasound therapy alone. These findings indicate that integrating hamstring stretching into TMD treatment protocols could improve rehabilitation outcomes.
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The Effect of Information on the Time Course of Pain During an Episode of Acute Experimentally Induced Low Back Pain-A Randomised Experiment
CONCLUSIONS: We simulated an episode of low back pain and found that information based on tissue sensitivity and advice to remain active did not improve pain compared to information referencing tissue damage and advice to rest and protect the back.
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Improving and preserving cardiorespiratory fitness, muscle strength and adiposity through a complex lifestyle intervention in community-dwelling older adults with elevated cardiometabolic risk: study protocol for the RESTART randomised controlled trial
INTRODUCTION: As the global population ages, the incidence of cardiometabolic diseases and associated healthcare costs rise. There is a critical need for preventive interventions enabling long-lasting treatment effects to address the decline in physical performance and metabolic health among older adults. The RESTART (RE-inventing Strategies for healthy Ageing: Recommendations and Tools) randomised controlled trial (RCT)…
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Long-term safety, tolerability, and efficacy of eptinezumab in chronic cluster headache (CHRONICLE): an open-label safety trial
BACKGROUND: Chronic cluster headache is an uncommon but highly debilitating primary headache disorder characterised by excruciating head pain recurring in daily attacks and without remission periods longer than 3 months. Treatment is challenging due to the few strategies available. Eptinezumab, approved for migraine prevention, is a humanised monoclonal antibody that targets calcitonin gene-related peptide, which…
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Comparison of extracorporeal shock wave therapy and high-intensity laser therapy in the treatment of calcaneal spur-related symptoms: clinical outcomes and functional improvement
CONCLUSION: ESWT and HILT are effective non-invasive options for treating calcaneal spur with ESWT providing slightly greater functional benefits.