Clinical Trials
Category Added in a WPeMatico Campaign
-
Controlled Intervention Study on Effects of an AI-Based App to Support Wound Care: First Results
The KIADEKU project combines datascience and the clinical expertise of wound experts to develop and evaluate an AI-application for incontinence-associated-dermatitis (IAD) and pressure ulcer (PU) wound care. The evaluation study is a controlled, non-randomized clinical trial that investigates the effects of the AI-based system on wound care time, guideline adherence and the task load of…
-
Becoming attack-free further improves health-related quality of life in patients with hereditary angioedema receiving garadacimab
Background: Hereditary angioedema (HAE) is associated with substantial health-related quality of life (HRQoL) impairments. Complete disease control and life normalization are key treatment goals. In previous studies, garadacimab prevented HAE attacks with a favorable safety profile and HRQoL improvements. Objective: HRQoL was evaluated in patients with HAE receiving garadacimab stratified by attack-free status. Methods: In…
-
Garadacimab improves long-term health-related quality of life in patients with hereditary angioedema
Background: Hereditary angioedema (HAE) attacks substantially impair health-related quality of life (HRQoL). Current World Allergy Organization and the European Academy of Allergy and Clinical Immunology guidelines goals include complete control and normalization of patients’ lives. Garadacimab (anti-activated factor XII monoclonal antibody) reduced the mean attack rate after first administration in the pivotal phase III (VANGUARD;…
-
Cost-effectiveness of school integrated pest management and air filtration in students with asthma
Background: The cost-effectiveness of school environmental remediation in asthma is not known. The School Inner City Asthma Intervention Study (SICAS2) was a randomized controlled trial that assessed school integrated pest management (IPM) and classroom high efficiency particulate air (HEPA) filtration on asthma morbidity in urban schools. Objective: The objective was to evaluate the cost-effectiveness of…
-
Insulin for early glycaemic abnormality in children with cystic fibrosis without cystic fibrosis-related diabetes (CF-IDEA): a randomised controlled trial
BACKGROUND: People with cystic fibrosis can have impaired insulin secretion and hyperglycaemia before meeting the diagnostic criteria for cystic fibrosis-related diabetes during an oral glucose tolerance test (OGTT). Insulin therapy given to such patients was associated with improved weight and lung function in several small, uncontrolled trials but might increase treatment burden and cause hypoglycaemia.…
-
SLE-DAS enables an accurate definition of severe lupus disease activity: derivation and validation in a post hoc study of anifrolumab phase II and III studies
CONCLUSION: The SLE-DAS cut-off for SDA provides an accurate definition of SDA in SLE, with good discriminative power and consistent associations with worse HR-QoL. This SLE-DAS definition enhances disease activity classification and offers a practical tool for guiding treatment decisions in clinical practice, as well as selecting patients with SDA for inclusion in clinical trials.
-
Outcomes of the linking exercise for advancing daily stress (LEADS) management and resilience randomized pilot trial in African American adolescents and families
CONCLUSIONS: This pilot feasibility trial demonstrates the acceptabity and feasibiity of integrating culturally sensitive strength-based interventions for African American families to promote health promotion behaviors and coping.
-
Cost-consequence analysis of an e-health intervention to reduce distress in dementia carers: results from the iSupport randomised controlled trial
CONCLUSION: Use of iSupport was associated with reduced health and social care resource use costs for carers compared with care-as-usual. Self-guided e-health interventions for dementia carers may have the potential to reduce health and social care resource use and wider societal costs, but evidence relating to their effectiveness and cost-effectiveness is lacking.
-
The role of comprehensive geriatric assessment in older patients affected by knee osteoarthritis: an exploratory randomized controlled trial
CONCLUSIONS: CGA may offer potential benefits for managing knee OA in older adults, particularly for pain and function, though statistical significance was not achieved. Larger studies with longer follow-up are warranted to confirm these findings.
-
Comparison of extended-release sildenafil with standard sildenafil in a randomized placebo-controlled study
CONCLUSION: «Vildegra» is not inferior to «Viagra» in efficiency and has better tolerability, which resulted in the higher frequency of on-demand use of «Vildegra».