Clinical Trials
Category Added in a WPeMatico Campaign
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A study on the safety and efficacy of a robotic-assisted navigation and positioning system in CT-guided percutaneous biopsy of thoracic and abdominal tumors
CONCLUSION: The robotic puncture navigation system improves the success rate of localization and reduces the number of puncture adjustments and CT scans; therefore, it is superior to the traditional step-by-step puncture method.
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Internal drainage of subretinal fluid during scleral buckling with 27-Gauge wide angle viewing system and flute needle for rhegmatogenous retinal detachment
CONCLUSION: Although limited by the small sample size, this study suggests that internal drainage of subretinal fluid during scleral buckling with 27-gauge WAVS and flute needle showed advantages superior to external drainage of subretinal fluid in scleral buckling surgery, including increased efficiency and decreased amount of SRF, shortened duration of persistent subretinal fluid, and reduced…
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Efficacy of photobiomodulation for the prevention and treatment of chemotherapy-induced oral mucositis in pediatric patients with hematologic cancers: a randomized clinical trial
CONCLUSION: PBM appears to be a safe and effective approach for the prevention of MTX-induced OM in pediatric patients with hematologic cancers. Additionally, PDT using ICG and a low-level laser demonstrates promising results in treating OM lesions. Therefore, these findings highlight the efficacy of PBM for managing MTX-induced OM in this patient group.
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Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer’s disease
CONCLUSIONS: Elevated baseline plasma NfL predicted more rapid clinical decline and MRI volume loss. Furthermore, increasing plasma NfL concentration over time was associated with worsening on the CDR-SB. Plasma NfL is an easily accessible biomarker that may enhance the design of clinical trials in mild-to-moderate AD.
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The effect of collagen sponge placed in the socket after surgical extraction of mandibular third molars on the incidence of alveolar osteitis: a split mouth randomized controlled trial
CONCLUSION: Intra-alveolar application of collagen sponge following surgical extraction of IL3rdM significantly reduced post-operative pain on days 3 and 7. Moreover, it can minimally decrease the incidence of AO.
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Efficacy of Adjunctive Cariprazine on Anxiety Symptoms in Patients With Major Depressive Disorder: Post Hoc Analysis of a Randomized Placebo-Controlled Trial
Objective: To evaluate the effects of adjunctive cariprazine on anxiety symptoms in adults with a DSM-5 diagnosis of major depressive disorder (MDD) and inadequate response to antidepressant therapy (ADT).
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Modified Borg Scale (mBorg), the Numerical Rating Scale (NRS), and the Dyspnea- 12 Scale (D- 12): cross-scale comparison assessing the development of dyspnea in early-stage lung cancer patients
CONCLUSION: This study highlights interscale concordance and key contributors to breathlessness in operable early-stage lung cancer patients. All three scales validly measure dyspnea, with the D-12 and NRS offering a holistic assessment by including affective-dyspnea scores.
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Trial and Participant Characteristics of a Home-Visiting Diabetes Intervention: The Together Overcoming Diabetes Study
Background: American Indians (AIs) endure the most severe health inequities in the nation, including disproportionately high rates of Type 2 diabetes (T2D). We describe baseline characteristics for AI participants enrolled in a culturally grounded, intergenerational, home-based T2D preventive intervention called Together Overcoming Diabetes (TOD). Methods: This community-based participatory research collaboration between five tribal nations and…
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Weight loss in MASLD restores the balance of liver fatty acid sources
BACKGROUNDLipogenesis contributes substantially to the pathological accumulation of intrahepatic triacylglycerol (IHTG) in metabolic dysfunction-associated steatotic liver disease (MASLD). Since hepatic lipogenesis is highly sensitive to energy intake, we hypothesized that mechanisms of MASLD regression induced by weight loss would be driven by a marked reduction in the lipogenic pathway.METHODSOverweight adults with high liver fat (HighLF;…
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Evaluation of scoring systems and hematological parameters in the severity stratification of early-phase acute pancreatitis
CONCLUSION: Independent risk factors for developing SAP include CRP(48), Ca^(2+), and PNI(48). CTSI, BISAP, and the combination of PNI(48) and the Ranson score can act as reliable predictors of SAP.