Clinical Trials
Category Added in a WPeMatico Campaign
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A Web-Based Tool to Perform a Values Clarification for Stroke Prevention in Patients With Atrial Fibrillation: Design and Preliminary Testing Study
CONCLUSIONS: Visual aids can modestly affect decision confidence and perceptions regarding the benefits of OAC but do not significantly alter decision certainty in a scenario where the guidelines do not recommend for or against OAC. Future work should determine the role of a gauge versus icon array visual for decision-making in stroke prevention in AF.
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Trajectories of Irritability Improvement in Depressed Adolescents Treated With 1 Hz and 10 Hz Transcranial Magnetic Stimulation
Objective: Irritability is a debilitating, transdiagnostic symptom in adolescents spanning internalizing and externalizing disorders, and early reduction in irritability with antidepressant treatments has been seen as a positive prognostic sign in depression recovery. There are substantial knowledge gaps regarding how transcranial magnetic stimulation (TMS) treatments impact irritability.
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Efficacy and Safety of Dulaglutide Biosimilar LY05008 Versus the Reference Product Dulaglutide (Trulicity) in Chinese Adults With Type 2 Diabetes Mellitus: A Randomized, Open-Label, Active Comparator Study
CONCLUSION: The primary endpoint was met in this study through the demonstration of equivalent efficacy in HbA1c reduction in Chinese adults with T2DM between LY05008 and dulaglutide. Overall, the biosimilar product LY05008 showed comparable safety, PK, and immunogenicity profiles against the reference drug dulaglutide.
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Laser patterned microcoagulation (LPM) in the management of desquamative gingivitis secondary to oral lichen planus: A randomized controlled pilot clinical trial (LPM TRIAL)
The application of laser patterned microcoagulation (LPM) for the management of desquamative gingivitis secondary to oral lichen planus (OLP) was investigated. This single-centre, randomized, sham-controlled, single-blinded, parallel-arm pilot clinical trial included 30 patients diagnosed with OLP manifesting only as desquamative gingivitis. Permuted block randomization was performed. LPM was performed in the test group and sham…
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Benefits of Adding a Psychomotor Therapy Over a Combined-Approach Treatment in Adults who Stutter: A Randomized Controlled Trial
CONCLUSIONS & IMPLICATIONS: This randomized controlled trial did not demonstrate any benefit of adding a psychomotor therapy over a standard combined-approach treatment in young AWS.
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3D-Printed anterior repositioning splint versus stabilization splint for patients with anterior disc displacement with reduction: A randomized cross-over clinical trial
CONCLUSION: Within the limitations of this study, both splints are considered reliable treatment options for patients with anterior disc displacement. The ARS initially demonstrated a greater improvement in pain compared to the SS. However, after the 3-month follow-up period, no significant difference was observed between the two splints.
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The efficacy of methylprednisolone acetate nanogel in treating patients with sudden sensorineural hearing loss
Intratympanic injection of methylprednisolone acetate is considered to be one of the effective drugs in the treatment of sudden sensorineural hearing loss. In this study, the efficacy of intratympanic injection of methylprednisolone acetate nanogel in patients with sudden sensorineural hearing loss was investigated. It is a double-blind randomized clinical trial in one of Iran’s hospitals.…
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Immediate effect of ice and dry massage during rest breaks on recovery in MMA fighters : a randomized crossover clinical trial study
The MMA fight consists of 5 rounds of 5 min with minimal breaks between the rounds. The exertion load is excessive for the fighters, and the 1-minute breaks give little time for any intervention. This study aimed to examine the acute effects of two methods of regenerative strategies, ice massage and dry massage, and analyze…
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Selective removal of dental caries in permanent teeth: an 18-month clinical trial
CONCLUSION: SRCT was clinically effective in both mid-depth (D2) and deep (D3) lesions, addressing pulp sensitivity and restoration quality. In D3 lesions, it minimized the risk of pulp exposure while preserving dentin integrity, while in D2 lesions, it preserved tooth structure without compromising restoration performance.
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Mitomycin C augmented canalicular silicone intubation versus external dacryocystorhinostomy in primary acquired nasolacrimal duct obstruction: a retrospective study
CONCLUSION: Silicon intubation with MMC is comparable to external DCR in terms of safety and efficacy, with the advantage of being a less invasive procedure, more accessible with a shorter learning curve, and shorter operative time in primary acquired NLDO.