Clinical Trials
Category Added in a WPeMatico Campaign
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Anaerobutyricum soehngenii improves glycemic control and other markers of cardio-metabolic health in adults at risk of type 2 diabetes
Anaerobutyricum soehngenii (previously Eubacterium hallii) is a butyrate-producing next-generation beneficial microbe generally recognized as safe. Several short-term intervention trials by A. soehngenii L2-7 have shown improvement of insulin sensitivity in prediabetic subjects and type 2 diabetes patients. To determine the long-term cardiometabolic benefits and safety, we performed a 3-month double-blind, randomized placebo-controlled intervention in 98…
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Comparison of two maneuvers to identify Carnett’s sign in patients with chronic abdominal pain. Randomized controlled clinical trial
CONCLUSION: The two ways of exploring the Carnett sign have similar efficacy. Infiltration with 2% lidocaine produced rapid and significant improvement of pain with minimal side effects. Not knowing the Carnett sign increases health costs.
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Non-Inferiority of Subcutaneous Efepoetin Alfa Compared to Methoxy Polyethylene Glycol-Epoetin Beta in Stage 3 or 4 CKD Patients: Insights From a Phase 3 Trial
CONCLUSION: Efepoetin alfa demonstrated non-inferiority to methoxy polyethylene glycol-epoetin beta in correcting anaemia and maintaining haemoglobin (Hb) levels among stage 3 and 4 CKD patients. Moreover, the safety profile of efepoetin alfa was comparable to methoxy polyethylene glycol-epoetin beta.
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Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab
CONCLUSIONS: WBC ≥ 70 × 10⁹/L is a high-risk feature in patients with Ph + ALL receiving frontline blinatumomab and ponatinib and may supersede the prognostic importance of baseline molecular features. Alternative frontline treatment strategies may be needed for these patients to reduce the risk of relapse and improve long-term outcomes.
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Synergistic Enhancement of Compromised Skin Radiance: A Clinical Investigation of Prinsepia utilis Royle Polysaccharides and Nonapeptide Co-Application
CONCLUSION: PCA analysis revealed PUR9-2 uniquely modulated gene expression compared to PURP and EQ9. Functional enrichment analysis based on Gene Ontology (GO) demonstrated PUR9-2 restored UVA-suppressed TNFAIP3 and CRNN gene. The results of RT-PCR also indicated that PUR9-2 enhanced skin barrier integrity in 3D models via upregulated expression of FLG, LOR, and DSG1. The Chou-Talalay…
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Transdiagnostic Cognitive Remediation Therapy for Patients with Eating Disorders: A Randomized Controlled Trial
Background/Objectives: Eating disorders (EDs) are associated with cognitive inefficiencies related to cognitive flexibility, central coherence, and inhibition. Transdiagnostic cognitive remediation therapy (TCRT) is a new adaption of cognitive remediation therapy aimed at addressing these difficulties across ED diagnoses. This study investigates the effects of TCRT as an adjunctive treatment for patients with EDs on cognitive…
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Comparison of extrafine and non-extrafine inhaled corticosteroids/long-acting beta2-agonists as maintenance and reliever therapy in asthma: a randomized open-label crossover trial
CONCLUSION: Our study demonstrated that extrafine ICS treatment provided no significant advantage over non-extrafine ICS in improving small airway obstruction or overall asthma control in moderate asthma. This suggests that factors other than particle size may contribute to treatment outcomes.
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Effects of probiotic and vitamin D co-supplementation on migraine index, quality of life, and oxidative stress in adults with migraine headache: a randomized triple-blinded clinical trial
CONCLUSION: This trial showed that probiotic plus vitamin D supplementation can favorably improve MI as well as serum levels of NO in adult patients with migraine. Further research on mechanisms through which the supplementation was effective on MI is warranted.
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Prescriptive Predictors of Mindfulness Ecological Momentary Intervention for Social Anxiety Disorder: Machine Learning Analysis of Randomized Controlled Trial Data
CONCLUSIONS: The AU-ROC values indicated moderately meaningful effect sizes in identifying prescriptive predictors within multivariable models for clients with SAD. Focusing on the identified notable client strengths, weaknesses, and Chinese ethnicity may enhance our ability to predict future responses to scalable treatments. Estimating the likelihood of SAD remission with a «prescriptive predictor calculator» for each…
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Feasibility and Potential Benefits of Moderate Intensity Cycling in People Living with Lower Limb Lymphedema: A Pilot Randomized Controlled Trial
The aim of this pilot randomized con-trolled trial (RCT) was to assess the feasibility of a moderate intensity cycling intervention in persons with lower limb lymphedema (LLL) and to explore its potential benefits. Thirty-three participants were included for an 8-week intervention of home-based exercise and randomized to an intervention group (IG) with cycling 3-5 times…