Clinical Trials
Category Added in a WPeMatico Campaign
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Evaluatıng the Role of Overactıve Bladder Dıagnosıs ın Predıctıng the Rısk of Postspınal Hypotensıon Durıng Electıve Cesarean Sectıon Operatıons: Randomızed Trıple-Blınded Study
CONCLUSION: The risk of postspinal hypotension in parturients with overactive bladder is higher. Higher caution must be taken for hypotension after SA intervention in patients with over active bladder.
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MANAGEMENT OF HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING PHOTOBIOMODULATION AND SEALANTS IN CHILDREN: A RANDOMIZED CLINICAL TRIAL
CONCLUSION: Both glass ionomer and resin-based sealants and PBM are effective in reducing hypersensitivity associated with MIH.
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The Desensitizing Effect of Nanosilver Fluoride Compared to Photobiomodulation Therapy in Molar-Incisor Hypomineralization: A Randomized Clinical Trial
CONCLUSION: NSF and PBMT reduced sensitivity associated with MIH and provided immediate pain relief. However, NSF was superior due to its longer-lasting effects on sensitivity and additional benefit in plaque reduction.
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A randomized controlled trial comparing large-volume band ligator and cyanoacrylate injection in the endoscopic management of actively bleeding gastric varices
Managing actively bleeding gastric varices (GV) is clinically challenging. This study assessed the safety and efficacy of endoscopic band ligation (EBL) using large-volume ligators compared with endoscopic variceal obturation (EVO) in managing actively bleeding GV. Patients who were diagnosed with active GV bleeding via endoscopy and underwent EBL with large-volume band ligators or EVO were…
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Effects of combined metformin and semaglutide therapy on body weight, metabolic parameters, and reproductive outcomes in overweight/obese women with polycystic ovary syndrome: a prospective, randomized, controlled, open-label clinical trial
CONCLUSION: Compared to MET monotherapy, combination therapy with semaglutide and MET significantly reduced body weight, improved insulin resistance, decreased inflammatory markers, alleviated and menstrual irregularities and increased natural pregnancy rates in overweight/obese women with PCOS.
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Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort
CONCLUSIONS: Our study has identified several baseline metabolites and metabolic pathways associated with disease activity and response to different treatments in early RA. By integrating metabolomics and clinical data, we developed predictive models for response to treatment in early RA, though their predictive performance remains limited.
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Safety findings from the phase 1/2 MOSAIC study of miransertib for patients with PIK3CA-related overgrowth spectrum or Proteus syndrome
CONCLUSION: Miransertib was safe and tolerable in participants with a confirmed diagnosis of PROS or Proteus syndrome. Future investigations are needed to determine whether patients receive measurable clinical benefit from miransertib.
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The VIP trial: a randomised controlled trial of the clinical effectiveness of a Victim Improvement Package (VIP) for the reduction of continued symptoms of depression or anxiety in older victims of community crime in an English city
CONCLUSIONS: Community crime had long-lasting impacts. The police are ideally placed to screen for distress, present in 35% of victims, but only 58% of participants were recruited and the cognitive-behavioural therapy was not delivered competently. Further research on victim care and improving the delivery and quality of therapy is required.
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Adherence to Quality-of-Care Indicators and Mortality Outcomes in Patients With MRSA Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this post hoc analysis of a randomized clinical trial, health care practitioners of trial participants had greater adherence to QCIs for MRSA bacteremia management compared with practitioners of nontrial patients. Trial participation was not associated with lower mortality.
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Modified Target Delineation and Moderately Hypofractionated Radiotherapy for High-Grade Glioma: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, modified target delineation with HSIB-IMRT demonstrated comparable PFS and OS to standard IMRT in patients with newly diagnosed HGG, while significantly reducing the irradiation target volume without increasing the recurrence rates outside the target volume. These results suggest valuable insights for future research aimed at personalized, reduced…