Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of customized orthoses on foot morphology and pressure in patients with accessory navicular syndrome
CONCLUSION: Customized orthoses effectively improved foot morphology and reduced plantar pressure in professional athletes with ANS compared to conventional insoles. These findings suggest that customized orthotic intervention provides faster and more significant pain relief for patients with ANS-related medial arch collapse.
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Assessment of guided lateral maxillary sinus lift procedure with simultaneous implant placement using stereolithographic surgical guide: a randomized controlled clinical study
CONCLUSION: According to the current study it has been concluded that there was no remarkable difference between the outcomes of both methods. The study protocol and its consent form were approved by the ethical committee of Suez Canal University (No.432/2021); and registered retrospectively on 23 April 2024 on PACTR (PACTR20240875463218) (pactr.samrc.ac.za/TrialDisplay.aspx?TrialID = 30442).
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Combining ranibizumab with calcium dobesilate to reduce injection frequency in diabetic macular edema treatment
CONCLUSION: Combination therapy with calcium dobesilate and ranibizumab decreased the frequency of intravitreal injections and led to greater improvements in BCVA and CMT compared to ranibizumab alone over 12 months. Both treatments were well-tolerated, with the combination therapy demonstrating a favorable safety profile.
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Controlled Intervention Study on Effects of an AI-Based App to Support Wound Care: First Results
The KIADEKU project combines datascience and the clinical expertise of wound experts to develop and evaluate an AI-application for incontinence-associated-dermatitis (IAD) and pressure ulcer (PU) wound care. The evaluation study is a controlled, non-randomized clinical trial that investigates the effects of the AI-based system on wound care time, guideline adherence and the task load of…
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Becoming attack-free further improves health-related quality of life in patients with hereditary angioedema receiving garadacimab
Background: Hereditary angioedema (HAE) is associated with substantial health-related quality of life (HRQoL) impairments. Complete disease control and life normalization are key treatment goals. In previous studies, garadacimab prevented HAE attacks with a favorable safety profile and HRQoL improvements. Objective: HRQoL was evaluated in patients with HAE receiving garadacimab stratified by attack-free status. Methods: In…
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Garadacimab improves long-term health-related quality of life in patients with hereditary angioedema
Background: Hereditary angioedema (HAE) attacks substantially impair health-related quality of life (HRQoL). Current World Allergy Organization and the European Academy of Allergy and Clinical Immunology guidelines goals include complete control and normalization of patients’ lives. Garadacimab (anti-activated factor XII monoclonal antibody) reduced the mean attack rate after first administration in the pivotal phase III (VANGUARD;…
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Cost-effectiveness of school integrated pest management and air filtration in students with asthma
Background: The cost-effectiveness of school environmental remediation in asthma is not known. The School Inner City Asthma Intervention Study (SICAS2) was a randomized controlled trial that assessed school integrated pest management (IPM) and classroom high efficiency particulate air (HEPA) filtration on asthma morbidity in urban schools. Objective: The objective was to evaluate the cost-effectiveness of…
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Insulin for early glycaemic abnormality in children with cystic fibrosis without cystic fibrosis-related diabetes (CF-IDEA): a randomised controlled trial
BACKGROUND: People with cystic fibrosis can have impaired insulin secretion and hyperglycaemia before meeting the diagnostic criteria for cystic fibrosis-related diabetes during an oral glucose tolerance test (OGTT). Insulin therapy given to such patients was associated with improved weight and lung function in several small, uncontrolled trials but might increase treatment burden and cause hypoglycaemia.…
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SLE-DAS enables an accurate definition of severe lupus disease activity: derivation and validation in a post hoc study of anifrolumab phase II and III studies
CONCLUSION: The SLE-DAS cut-off for SDA provides an accurate definition of SDA in SLE, with good discriminative power and consistent associations with worse HR-QoL. This SLE-DAS definition enhances disease activity classification and offers a practical tool for guiding treatment decisions in clinical practice, as well as selecting patients with SDA for inclusion in clinical trials.
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Outcomes of the linking exercise for advancing daily stress (LEADS) management and resilience randomized pilot trial in African American adolescents and families
CONCLUSIONS: This pilot feasibility trial demonstrates the acceptabity and feasibiity of integrating culturally sensitive strength-based interventions for African American families to promote health promotion behaviors and coping.