Clinical Trials
Category Added in a WPeMatico Campaign
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Cerebellar Stimulation Modulates Reward Processing: A High-definition Transcranial Direct Current Stimulation Study
Reward processing involves several components, including reward anticipation, cost-effort computation, reward consumption, reward sensitivity, and reward learning. Recent research has highlighted the cerebellum’s role in reward processing. This study aimed to investigate the effects of cerebellar stimulation on reward processing using high-definition transcranial direct current stimulation (HD-tDCS). In this single-blind, randomized, sham-controlled study, 63 healthy…
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Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Living-Donor Nephrectomy
CONCLUSIONS: Although erector spinae plane blocks applied under bilateral ultrasonographic guidance did not have any efficacy for pain relief in the first 24 hours postoperation, a decrease was found in analgesic consumption compared with the nonblock group.
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Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma
CONCLUSION: Both forms of TXA are effective with low side effects. The choice between oral and topical TXA can depend on patient preference and convenience.
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Digital Psychological Intervention for Inflammatory Rheumatic Diseases: A Pilot Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This pilot randomized clinical trial supports the effectiveness and safety of a digital psychological intervention in individuals with IRDs. These findings suggest that such digital interventions could be a valuable, scalable approach to addressing mental health needs in rheumatology.
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In-the-Bag Behavior of a New Aspheric Hydrophobic Acrylic Toric Intraocular Lens
CONCLUSIONS: Tilt and decentration of the Clareon TIOL were generally low and a strong correlation was found between crystalline lens tilt and TIOL tilt at 6 months.
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Observation on the efficacy of moxibustion with fuzi cake combined with auricular point pressing in treating anxiety and depression in newly diagnosed people living with HIV: A randomized controlled trial
CONCLUSION: Moxibustion with aconite cake combined with earlobe acupressure can effectively alleviate anxiety and depression in newly diagnosed human immunodeficiency virus patients, enhance their quality-of-life, and may improve immune function. The treatment is safe and well — tolerated, with good clinical potential for application and promotion.
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Efficacy of Facial Botulinum Toxin A Injections in Alleviating Neuropsychiatric Symptoms in Parkinson’s Disease Patients: An Open-Label, Nonrandomized Controlled Trial
CONCLUSIONS: In summary, BTX-A demonstrates efficacy in reducing multiple neuropsychiatric symptoms (such as tension, anxiety, depression, sensitivity, etc.) in PD, with comparable effectiveness to CH, supporting its consideration as an alternative therapeutic option.
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Evaluating the Effectiveness of a Hybrid Tai Chi Cardiac Rehabilitation Programme for Psychological Stress Reduction and Oxidative Stress in Patients With Chronic Coronary Syndrome: A Randomized Controlled Trial
Preliminary evidence suggests that Tai Chi may effectively relieve pain symptoms, increase quality of life, and reduce cardiovascular risk in patients with chronic coronary syndrome (CCS). However, few randomized controlled trials have specifically investigated the potential benefits of Tai Chi in patients with CCS, particularly regarding its effects on psychological stress and cellular stress levels.…
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Effect of Empagliflozin on the plasma lipidome in patients with type 2 diabetes mellitus: results from the EmDia clinical trial
CONCLUSION: This study identified distinct lipid signatures associated with Empagliflozin treatment after both one and twelve weeks, respectively, with five lipids overlapping between signatures and three with consistent directions, revealing that some of the beneficial effects of Empagliflozin could be through lipid modulation. Notably, Empagliflozin-modulated lipids associated with changes in clinical traits and lipid-specific profiles…
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An early prediction of postprandial glycemia evolution using the MD001 algorithm: a muticentre prospective trial
To date, the closed-loop system represents the best commercialized management of type 1 diabetes. However, mealtimes still require carbohydrate estimation and are often associated with postprandial hyperglycemia which may contribute to poor metabolic control and long -term complications. A multicentre, prospective, non-interventional clinical trial was designed to determine the effectiveness of a novel algorithm to…