Clinical Trials
Category Added in a WPeMatico Campaign
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Outcomes and experiences of DIALOG+ provided remotely for patients with anxiety disorders-A non-controlled pilot trial
CONCLUSIONS: The findings suggest that DIALOG+ is feasible and beneficial for patients with anxiety disorders in routine care and that a remote delivery is a feasible realistic option for administering it. Future research should assess implementation methods and effectiveness in larger controlled trials and identify the effective mechanisms in DIALOG+.
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Personalized Visual Perceptual Learning Digital Therapy for Visual Field Defects Following Stroke: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of a digital therapeutic for chronic poststroke VFDs, the visual perceptual learning-based training demonstrated significant improvements in the whole field and defective hemifield.
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Peri-Implant Diseases: Enhanced Antibacterial Photodynamic Therapy
CONCLUSIONS: Regularly applied dual-light aPDT reduces inflammation in the dental implant adjacent tissues. Dual-light aPDT approach holds promise as an effective home care tool for implant patients.
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Clinical Validation of a Vaginal Cervical Cancer Screening Self-Collection Method for At-Home Use: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this nonrandomized clinical trial, SC samples collected with the device showed equivalent clinical sensitivity and exceeded the PPA end point for cervical screening. This SC method was found to be easy to use and to be a preferred option with high clinical performance intended for use in an at-home setting.
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT
CONCLUSIONS: In this underpowered study, the addition of bisoprolol to usual chronic obstructive pulmonary disease treatment did not reduce the likelihood of exacerbations, and bisoprolol cannot be recommended as a treatment for chronic obstructive pulmonary disease.
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Brief intensive EMDR therapy for PTSD in adults with mild intellectual disability or borderline intellectual functioning and behavioural problems: a multiple baseline design study
Background: Individuals with mild intellectual disability (MID; IQ 50-70) or borderline intellectual functioning (BIF; IQ 70-85) are at an elevated risk of post-traumatic stress disorder (PTSD), with PTSD symptoms possibly associated with behavioural problems. It is important to test the effectiveness of trauma-focused treatments, such as eye movement desensitisation and reprocessing (EMDR) therapy, for adults…
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Albuterol Digihaler in COPD Disease Management: A Real-World Study to Assess Digihaler Inhalation Parameters, Thresholds and Their Use to Identify Deterioration in Clinical Practice
CONCLUSION: Our study suggests that alert thresholds based on Digihaler device-measured physiologic parameters may have value in a predictive model for clinical deterioration in COPD.
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT
CONCLUSIONS: In children hospitalised with confirmed or suspected bacterial infection, the addition of a procalcitonin-guided algorithm to usual care is non-inferior in terms of safety, but does not reduce duration of intravenous antibiotics, and is not cost-effective. In the presence of robust antimicrobial stewardship programmes to reduce antibiotic use, a procalcitonin-guided algorithm may offer little…
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Bleaching efficacy and tooth sensitivity using violet LED — single-blind randomized controlled trial
This study aims to conduct a single-blind randomized controlled trial to evaluate the bleaching efficacy and tooth sensitivity (TS) following the use of violet LED associated or not with 35% hydrogen peroxide. Eighty-four participants were randomly allocated into three groups according to bleaching treatments (n = 28): 35% hydrogen peroxide (HP) only, Violet LED only…
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Effectiveness of an educational intervention on the components of the metabolic syndrome of adults with type 2 diabetes: non-randomized clinical trial
CONCLUSION: A nurse-led health promotion educational program was effective in improving glucose and high-density lipoprotein cholesterol levels among adults with type 2 diabetes and metabolic syndrome, as well as reducing the number of metabolic syndrome components in the participants.