Clinical Trials
Category Added in a WPeMatico Campaign
-
Exploring Neurobiological Effects of Intermittent Theta-Burst Stimulation on the Left Cerebellum for Post-stroke Unilateral Neglect: A Preliminary Transcranial Magnetic Stimulation-Electroencephalography Investigation
Unilateral neglect (UN) is a frequent consequence of stroke, for which effective therapeutic interventions are yet to be definitively established. This study aims to assess the therapeutic potential of intermittent theta-burst stimulation (iTBS) applied to the contralesional cerebellum in reducing UN symptoms. Additionally, it seeks to clarify the neurophysiological mechanisms involved, thereby supporting the development…
-
Efficacy of a 1% ibuprofen nanostructured topical gel in reducing in-office bleaching sensitivity following 35% hydrogen peroxide application: a randomized, controlled, triple-blind, split-mouth clinical trial
CONCLUSION: The novel 1% ibuprofen nanostructured topical gel was ineffective in reducing BS and did not affect tooth color change.
-
Advancing dementia preparedness in Low and Middle Income countries: A randomized trial to improve diagnosis in primary care
INTRODUCTION: Dementia disproportionately affects individuals in low- and middle-income countries (LMICs), yet diagnostic capabilities there are often inadequate. This study assesses the impact of a structured training program for primary care physicians (PCPs) in Cuba to improve early dementia detection.
-
Clinical and radiographic evaluation of Er: YAG laser-assisted direct pulp capping in permanent teeth with carious exposure
CONCLUSION: The inclusion of Er: YAG laser in DPC procedures enhances treatment outcomes, particularly when combined with Biodentine. This approach offers a promising alternative for vital pulp therapy in mature permanent teeth, ensuring better dentin bridge formation and clinical success.
-
The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota composition in individuals with stage III-IV periodontitis: a randomized controlled trial
CONCLUSIONS: Combining L. reuteri with non-surgical periodontal therapy may not directly improve clinical indicators. The treatment showed potential benefits by changing the microbial composition of subgingival biofilm and enhancing treatment sensitivity.
-
Efficacy and safety of prophylactic simultaneous intravitreal moxifloxacin injection with standard intravitreal anti-VEGF injection procedure in cases of cystoid macular edema and macular neovascularization
CONCLUSION: Simultaneous intravitreal injection of moxifloxacin during intravitreal anti-VEGF procedure is safe and effective measure to be added to the armamentarium of prophylaxis against post injection endophthalmitis.
-
Patient Reactions to Artificial Intelligence-Clinician Discrepancies: Web-Based Randomized Experiment
CONCLUSIONS: Radiologists who recommend less testing than AI may face decreased patient confidence in their expertise, but they may not face this same penalty for giving more aggressive recommendations than AI. Patients’ reactions may depend in part on whether their general preferences to maximize or minimize align with the radiologists’ recommendations. Future research should test…
-
Acute Glucose Tolerance in Response to Lower- and Higher-Load Resistance Exercise in Postmenopausal Women: Contribution of Aerobic Capacity and Body Composition
Paquin, J, St-Martin, P, Lord, S-E, Gendron, P, Brochu, M, and Dionne, IJ. Acute glucose tolerance in response to lower- and higher-load resistance exercise in postmenopausal women: Contribution of aerobic capacity and body composition. J Strength Cond Res 39(6): e749-e757, 2025-Glucose tolerance (GT), fat-free mass (FFM), and V̇o2peak are known to decline after menopause. Exercise…
-
Comparison of Therapeutic Outcomes Between Concomitant Therapy and Tailored Therapy for Helicobacter pylori: A Multicenter, Prospective, and Randomized Study
CONCLUSION: Considering the high eradication success rate and low severity of adverse effects, tailored therapy based on DPO-PCR is preferable to concomitant therapy without resistance testing for the treatment of H. pylori infection.
-
Epicardial ablation in high-risk Brugada syndrome to prevent ventricular fibrillation: results from a randomized clinical trial
CONCLUSION: Epicardial catheter ablation was associated with a reduction in VF recurrence compared with ICD therapy alone. These findings support the use of epicardial ablation in high-risk BrS patients.