Clinical Trials
Category Added in a WPeMatico Campaign
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Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial
CONCLUSIONS: Apart from a positive effect on the patients’ post operative pain perception, I-PRF with or without the addition of vitamin C does not additionally improve the clinical outcomes of PMPR alone in the NSPT of stage-II grade A periodontitis patients.
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Cost-effectiveness of massed versus spaced trauma-focused treatment as first-line treatment for post-traumatic stress disorder in adults with multiple trauma exposure: protocol for a single-blind non-inferiority randomised controlled trial
INTRODUCTION: Post-traumatic stress disorder (PTSD) is a serious disorder that burdens individuals and society. The current standard of first-line treatment for PTSD is spaced trauma-focused treatment (S-TFT), involving weekly sessions. While effective, S-TFT may take relatively long to complete, especially in patients exposed to multiple potentially traumatic events (PTEs). Massed trauma-focused treatment (M-TFT), involving increased…
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Efficacy of sensorimotor training combined with core strength training for low back pain in adult idiopathic scoliosis: a study protocol for a randomized controlled trial
INTRODUCTION: Sensorimotor training (SoMT) is a gradual balance training technique employed to treat various chronic musculoskeletal pain. Core strength training (CST) is one of the most commonly used interventions for managing low back pain (LBP). This randomied controlled trial protocol aims to determine whether the combination of SoMT and CST can significantly reduce LBP, and…
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Extended CT angiography versus standard CT angiography for the detection of cardioaortic thrombus in patients with ischaemic stroke and transient ischaemic attack (DAYLIGHT): a prospective, randomised, open-label, blinded end-point trial
BACKGROUND: Cardioembolic sources often remain undetected after standard diagnostic stroke workup, contributing to high rates of recurrence. We aimed to assess whether a head-to-neck CT angiography extended at least 6 cm below the carina (extended CT angiography) can increase the detection of cardioaortic thrombi compared with standard-of-care CT angiography (standard CT angiography) in patients with…
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ExtraCECI: a community-based person-centred-enhanced care intervention to improve the quality of life and person-centred outcomes for people living with HIV/AIDS in Ghana-protocol for cluster randomised controlled trial
INTRODUCTION: People living with HIV/AIDS (PLWHA) have complex physical, psychological, social and spiritual needs following diagnosis and poorer health-related quality of life than the general population. Holistic assessment and care delivery incorporating person-centred principles is required to address these needs. This protocol describes a cluster randomised controlled trial (cRCT) and process evaluation to evaluate the…
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Impact of Providing an Automated Telephone Option to Report Weekly Patient-Reported Outcome Measures in the PRO-TECT Trial (AFT-39) on Disparity Gaps in Symptom Management and Outcomes
CONCLUSION: One third of community patients choose a telephone option over the web for reporting PROMs during cancer care. These patients are disproportionately from SDOH backgrounds at risk of poor clinical outcomes and have higher symptom management needs but ultimately experience similar clinical benefits as patients choosing the web. PROM programs should offer web alternatives…
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Comparison of Antiseptics Containing Povidone-Iodine and Hypochlorous Acid Active Substances in Preventing Central Catheter-Related Bloodstream Infection in Intensive Care Units: A Randomized Controlled Trial
CONCLUSION: In the study findings, central venous catheter-related bloodstream infection was observed to be less in catheter dressings applied with an antiseptic containing hypochlorous acid active substance than in catheter dressings applied with povidone-iodine. Hence, it is recommended to expand the use of an antiseptic containing hypochlorous acid active substance in catheter dressings.
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The Effects of Pulmonary Rehabilitation Applied to Intensive Care Unit Patients on Dyspnea, Quality of Life, Depression, Anxiety, and Daily Living Activities: A Randomized Controlled Study
CONCLUSION: It was found that PR applied both during the intensive care unit stay and at home by using the telerehabilitation method decreased anxiety, depression, and dyspnea in patients with COVID-19 and affected the quality of life and daily living activities positively. Continuing PR, which was applied to acute respiratory patients in the hospital and…
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Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial
CONCLUSIONS: This trial provides initial evidence that, with the right guardrails and process, generative AI can be successfully used in a digital mental health intervention (DMHI) while maintaining the user experience and relationship. It also provides an initial blueprint for approaches to technical and conversational guardrails that can be replicated to build a safe DMHI.
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An App-Based WHO Mental Health Guide for Depression Detection: A Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This feasibility cluster randomized clinical trial demonstrated that the use, cost, and potential clinical benefit of the e-mhGAP-IG varied by setting, highlighting the importance of multisite feasibility studies when evaluating digital innovations intended for health care systems worldwide.