Clinical Trials
Category Added in a WPeMatico Campaign
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Preoperative enema for anal surgery: randomized clinical trial
CONCLUSION: Preoperative enema in anal surgery did not yield additional benefits or reduce complications when compared with patients who did not undergo enema before anal surgery. Based on the study findings, its use can be omitted in anal surgery, especially for patients undergoing stapled haemorrhoidopexy and anal fistula surgery.
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Comparative study of different treatment modalities for melasma: introducing a novel nanotechnology-based tranexamic acid microemulsion
Melasma therapy remains challenging due to limited effectiveness, side effects, and relapses. Topical tranexamic acid (TXA) is promising but requires further research to optimize its formulation. Alongside the therapeutic benefit of fractional CO2 laser (FCL) in melasma, FCL and microneedling (MN) are recognized methods for transepidermal drug delivery. Nanotechnology-based topicals can enhance drug penetration and…
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial
CONCLUSIONS: No change in clinical practice can be recommended as there was not a significant difference between pramipexole and placebo on the primary efficacy outcome measure. However, there was evidence of positive effects of pramipexole on mood, psychosocial function and quality of life.
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Effectiveness of Cardiac Rehabilitation in Enhancing Adherence and Improving Clinical Outcomes Post-Acute Coronary Syndrome: A Randomized Controlled Trial
CONCLUSION: Cardiac rehabilitation significantly enhances adherence to medical and lifestyle recommendations, reduces complications, and improves outcomes in ACS patients. These findings emphasize the critical role of structured rehabilitation in post-ACS management.
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Evaluation of perioperative correction of nutritional deficiency in patients with complicated forms of esophageal and gastric cancer
CONCLUSION: This study of domestic and imported drugs for enteral nutrition demonstrates comparable, and in some key indicators, higher clinical and economic efficiency of domestic enteral nutrition products in the perioperative period in cancer patients with nutritional status disorders.
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Cost-Effectiveness of Personalised Nutrition in Adults With Overweight and Obesity: PREVENTOMICS Studies in Poland and the UK
CONCLUSIONS: The PREVENTOMICS interventions may offer a cost-effective approach to reduce weight and avoid its related complications in both countries. Future studies should be larger and/or longer to reduce uncertainty about effectiveness.
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A randomized trial to evaluate the impact of breast density notification on anxiety, breast cancer worry, and perceived risk among Latinas at a federally qualified health center : Breast density notification and anxiety, breast cancer worry, and perceived risk among Latinas
CONCLUSION: This Latina cohort had high levels of anxiety and BC worry which persisted regardless of intervention received. Future work is needed to improve our understanding of factors that could lower anxiety and BC worry and improve BC risk perception in this population.
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Effect of intermediate airway management on ventilation parameters in simulated paediatric out-of-hospital cardiac arrest: a multicentre randomised crossover trial
CONCLUSION: In a simulated paediatric out-of-hospital cardiac arrest model, immediate use of intermediate airway management did not show relevant differences compared to bag-valve-mask. Intermediate airway management devices cannot be recommended as first-line choice but may be considered when bag-valve-mask is challenging. Whichever device is used, the focus should remain on providing high-quality ventilations.
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Evaluating the impact of various predictors on rapid maxillary expansion (RME) success
CONCLUSIONS: Patients with a higher stage of MSM and CVM had a greater risk of RME failure. Additionally, patients with a lower density ratio and shorter palate length had a better prognosis for conventional RME.
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Depressive Personality Vulnerability and Adaptation to Breast Cancer: A Matter of Self-Criticism?
Dependency and self-criticism are two dimensions of personality vulnerability to depression, whereas efficacy is a dimension of personality resilience. The aim of this study was to examine the unique role of these personality dimensions in adaptation following a diagnosis of breast cancer, while controlling for the potentially confounding role of symptoms of depression and anxiety.…