Clinical Trials
Category Added in a WPeMatico Campaign
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Within-Trial Cost-Effectiveness Analysis of a Family-Based Structured Lifestyle Modification Intervention Program for Cardiovascular Risk Reduction: Results from the PROLIFIC Trial
CONCLUSIONS: A family-based structured lifestyle modification program yields a net gain in quality of life and is cost-effective at a three times gross domestic product per capita threshold. The intervention is expected to be relatively more cost-effective when scaled up to larger populations over longer time horizons. The intervention has the potential for a substantial…
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Within-Trial Cost-Effectiveness Analysis of a Family-Based Structured Lifestyle Modification Intervention Program for Cardiovascular Risk Reduction: Results from the PROLIFIC Trial
CONCLUSIONS: A family-based structured lifestyle modification program yields a net gain in quality of life and is cost-effective at a three times gross domestic product per capita threshold. The intervention is expected to be relatively more cost-effective when scaled up to larger populations over longer time horizons. The intervention has the potential for a substantial…
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Electroceutical enhancement of self-compassion training using transcutaneous vagus nerve stimulation: results from a preregistered fully factorial randomized controlled trial
CONCLUSION: tVNS augmented the effects of SC-MIT and might, therefore, be a useful strategy for enhancing meditation-based psychotherapies. Our findings also highlight the value of oculomotor attentional metrics as responsive markers of self-compassion training and the continued need for sensitive indices of successful vagal stimulation.
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Clinical Value of Metagenomic Next-Generation Sequencing in Early Diagnosis of Peritoneal Dialysis-Associated Peritonitis: A Randomised Controlled Observational Trial
CONCLUSION: Integrating mNGS into diagnostic workflows enhances pathogen detection efficiency, accelerates results, and improves the precision of antimicrobial therapy. These advantages suggest that mNGS-guided strategies may optimise clinical management of PDAP.
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Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT
CONCLUSION: Specialist physiotherapy was not superior to treatment as usual for the primary outcome, the Short Form questionnaire-36 items Physical Functioning domain at 12 months. However, a number of secondary outcome measures favoured specialist physiotherapy at 6 and 12 months. There is a high probability that specialist physiotherapy is cost-effective.
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Tailored interventions for inappropriate psychotropic drug use in nursing home residents with dementia: participatory action research in a special case of a stepped-wedge cluster randomized controlled trial
CONCLUSIONS: No reduction of inappropriateness was found although overall usage was reduced. Professionals focused on implementing alternatives to compensate for usage, rather than prescribing quality. Future studies may focus on changing physicians’ prescribing behaviors in combination with multicomponent and multidisciplinary psychosocial alternatives.
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Effectiveness of SOLIUS UVB Light System in Enhancing Serum 25-Hydroxyvitamin D Concentrations: A Randomized Controlled Trial
CONCLUSION: The SOLIUS system effectively increased 25(OH)D concentrations in individuals with vitamin D deficiency or insufficiency, offering a safe solution for improving vitamin D status. These findings have significant implications for public health, particularly for individuals with limited sun exposure or malabsorption issues.
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A Risk Stratification Model for Predicting Benefits of Intensive Blood Pressure Treatment: Analysis of the Systolic Blood Pressure Intervention Trial
Current hypertension guidelines lack personalized strategies for blood pressure control. While the Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated benefits of intensive blood pressure lowering, identifying optimal candidates for such treatment remains challenging. We developed and validated a risk stratification model using data from 9139 SPRINT participants. The model incorporated 11 clinical variables through multivariable…
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Three-dimensional multiple object tracking (3D-MOT) performance in young soccer players: Age-related development and training effectiveness
CONCLUSIONS: This research provide evidence that the 3D-MOT performance of young soccer players exhibits an increase between 13 and 15. Moreover, the results showed a significant training improvement in youth soccer players, but there was no significant relationship between the age-related development of 3D-MOT and the training effect in young soccer players. The above results…
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Low Testosterone Level and Mortality Risk in Patients With Prostate Cancer: A Post-Randomization Analysis
CONCLUSION: Unlike PSA, multiparametric MRI (mpMRI) images are not influenced by the serum testosterone level; therefore, evaluating whether PCSM can be reduced by incorporating mpMRI into PC-screening in otherwise healthy men or transgender women with a low serum testosterone level should be considered.