Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of simvastatin on expression of Interleukins 6 & 10 and Matrix Metalloproteinase: 9 when used as an intracanal medicament in teeth with symptomatic apical periodontitis-a triple blind randomized controlled trial
CONCLUSIONS: The expression of these biomarkers indicates that simvastatin is effective in reducing inflammation and pain in teeth with pulpal necrosis and symptomatic apical periodontitis when used as an intracanal medicament compared to Ca(OH)₂.
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The impact of a love language game intervention on relationship satisfaction among Chinese couples in China and Malaysia: examining the role of individualism-collectivism
CONCLUSION: This study contributes to the literature on love language-based interventions and their application in culturally diverse settings, offering valuable insights for relationship counsellors, educators, and policymakers. The findings may guide the development and implementation of culturally sensitive interventions to enhance relationship satisfaction and overall well-being in diverse populations.
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LODESTAR: A Single-Arm Phase II Study of Rucaparib in Solid Tumors With Pathogenic Germline or Somatic Variants in Homologous Recombination Repair Genes
CONCLUSION: Rucaparib has activity in HRDsig+ solid tumors with PVs in homologous recombination repair genes, regardless of histology. Platinum sensitivity correlated with improved outcomes.
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Device-Based Physical Activity and Low-Grade Inflammation in People With Multimorbidity: Cross-Sectional Baseline Analysis From the MOBILIZE Trial
Physical activity (PA) has anti-inflammatory effects, but its impact on individuals with multimorbidity (two or more chronic conditions) is unclear. We examined the association between device-measured (i.e., accelerometers) PA and inflammatory biomarkers in people with multimorbidity. In a, preplanned, cross-sectional analysis from the MOBILIZE trial, 214 participants with multimorbidity provided data on PA and inflammatory…
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Safety and Efficacy of Reduced-Port Versus Conventional Laparoscopic Distal Gastrectomy for Early Gastric Cancer: A Multicenter, Randomized, Non-inferiority Trial (KLASS-12)
CONCLUSIONS: RPLG is a feasible and safe alternative for patients with EGC, and its short-term outcomes are not inferior to those of CPLG.
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Gamified Telerehabilitation in Oligoarticular Juvenile Idiopathic Arthritis: A Randomized Controlled, Single-Blind Trial
CONCLUSION: The 6-week gamified telerehabilitation program reduced pain symptoms and kinesiophobia behaviors while improving the participants’ quality of life and mobility.
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A public health perspective on virtual reality interventions: exploring the impact of VR extreme sports on stress, anxiety, and depression in men with social anxiety disorder
CONCLUSION: These findings highlight the promise of VR-based extreme sports as a novel, non-pharmacological intervention for men with SAD. By enabling controlled exposure to anxiety-provoking situations within a safe and immersive environment, the intervention effectively alleviated symptoms of depression, anxiety, and stress. Moreover, this approach may overcome common treatment barriers such as stigma and reluctance…
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Pilot Trial of SDX/d-MPH Adult ADHD Examining Effects Throughout the Day
CONCLUSIONS: This pilot study is the first systematic treatment effect trial data for SDX/d-MPH in adults with DSM-5 ADHD. The data preliminarily supports the clinical efficacy of DSM/d-MPH in adult ADHD and its ability to ameliorate symptoms throughout the day.
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Heel kicking exercise rapidly improves pain and function in patients with acute lateral ankle sprain: a randomized controlled trial
CONCLUSIONS: HKE is a method designed to provide rapid movement rehabilitation for patients with ankle sprains, which can be used as one of its basic treatments.
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Effectiveness of a web-based decision aid for patients with Generalised Anxiety Disorder in Spain: a randomised controlled trial
CONCLUSION: The use of the PtDA led to improvements in knowledge at 3 months, but it did not result in a significant reduction of decisional conflict. These results must be interpreted with caution, given the methodological limitations of the study, mainly the high rate of dropouts. Further research is needed to confirm these results, the…