Clinical Trials
Category Added in a WPeMatico Campaign
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Addiction Consult Services, Mortality, and Acute Care Utilization in Inpatients With Opioid Use Disorder: A Secondary Analysis of a Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this prespecified secondary analysis of a cluster randomized clinical trial, postdischarge ED visits decreased with the CATCH program, highlighting the potential of hospital-based addiction consult services to address needs of patients with opioid use. Nonetheless, high rates of acute care utilization and mortality persisted, underscoring the need for comprehensive care strategies…
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Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial
Objective: This study evaluated whether depressive symptom severity improved early with extended-release naltrexone and bupropion combination (naltrexone bupropion) compared to a placebo in individuals with moderate/severe methamphetamine use disorder and predicted subsequent use of methamphetamine.
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Efficiency of remote monitoring and guidance in blood pressure management: a randomized controlled trial : The role of remote monitoring in improving hypertension management
CONCLUSIONS: Remote monitoring and guidance enhanced the efficiency of BP management, whereas self-monitoring alone proved to be ineffective.
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Mom Supporting Mom: Effective Peer Support Intervention for Women with Postpartum Psychological Distress
Objective: Untreated perinatal mental health disorders can have serious consequences for the whole family system. The purpose of this study was to examine the effectiveness of peer support intervention in improving postpartum psychological distress. Method: We evaluated a remote peer support intervention, Mom Supports Mom, in a randomized controlled trial. The primary study outcome was…
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Acceptability and implementation potential of a health literacy intervention to increase colorectal cancer screening in deprived areas: A qualitative study of patients and general practitioners participating in a cluster randomized controlled trial
CONCLUSION: Our findings emphasize the need to tailor promotional materials for both patients and healthcare professionals to improve CCR screening uptake, balancing digital efficiency with maintaining core human relationships in healthcare. Such intervention can be integrated into different workflows. The addition of video into national CRC screening programs might also help. Targeting CRC screening interventions…
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The Impact of Clustered Care on Itch Severity and Sleep Quality in Patients with Atopic Dermatitis via an Online Platform
This study investigated the efficacy of clustered care delivered via an online platform for adult atopic dermatitis patients. Ninety-eight atopic dermatitis patients from the Second Hospital of Hebei Medical University (May 2022-May 2024) were randomly assigned to a study group (online clustered care) or a control group (routine care), with 49 in each. Outcomes, including…
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Guided Internet-Based Cognitive Behavior Therapy for Women With Bulimia Nervosa: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the intervention group experienced a significant decrease in bulimia symptoms compared with the control group, supporting the effectiveness and acceptability of the therapist-guided ICBT program. These findings suggest that integration of therapist-guided ICBT in usual care has the potential to improve accessibility to efficacious treatment options for…
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Effect analysis of flexible bronchoscopy in thoracoscopic surgery for congenital pulmonary airway malformation
The objective of this study is to investigate the clinical efficacy of flexible bronchoscopy (FB) in thoracoscopic surgery for congenital pulmonary airway malformation (CPAM) in pediatric patients. We randomly divided the CPAM patients who underwent thoracoscopic surgery at our hospital from May 2022 to January 2024 into 2 groups based on whether they received FB…
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Set configuration influences cardiovascular responses to resistance exercise in postmenopausal females in a randomized crossover trial from the CARE project
This study evaluated the acute cardiovascular responses to resistance exercise (RE) sessions with different set configurations in normotensive and hypertensive postmenopausal females. 50 physically active postmenopausal females performed a control (CON) and three RE sessions matched for total volume (144 repetitions), load (12-repetition maximum load), and total rest time (360s) but differing in set configuration:…
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Deciphering differential biomarkers for anti-interleukin-6 receptor and anti-tumour necrosis factor-α treatment response in rheumatoid arthritis by multiomics analysis
CONCLUSION: The unbiased analysis of serum proteins identified biomarkers most predictive of anti-IL-6R and anti-TNF-α at different timepoints that could explain the difference in the response rate in patients with RA. Further, both biomarker and pathway results highlighted a differentiated mode of action of both treatments.