Clinical Trials
Category Added in a WPeMatico Campaign
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Sleep quality patterns in patients with heart failure: a person-centred latent class analysis from a secondary analysis of the MOTIVATE-HF trial
CONCLUSIONS: Patients with HF exhibit heterogeneous sleep quality patterns with specific clinical and psychological profiles. These findings highlight the need for personalised interventions, systematic sleep assessments and the integration of cardiac rehabilitation strategies into standard HF care.
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Psychoeducation Group for Depression (PEG-D): Study protocol for a prospective, randomized, single-blind, crossover trial
BACKGROUND: Considered a leading contributor to the global health burden, depression is characterized by its multifaceted nature. Recognizing the limitations of pharmacological treatments, non-pharmacological alternatives have been suggested to enhance full remission and increase quality of life.
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A Digital Therapeutic Intervention for Inpatients With Elevated Suicide Risk: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the digital therapeutic intervention did not change the time to first actual suicide attempt but helped to sustain reductions in suicidal ideation among inpatients with elevated suicide risk. However, among patients with prior suicide attempts, the digital therapeutic intervention helped reduce recurrent suicide attempts and increased the…
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Osa in women: When does cpap increase blood pressure?
CONCLUSION: Greater age, the presence of depression and higher baseline AHI and SBP were independently associated with a clinical significant increase in BP after CPAP, regardless of their adherence. These changes in BP appeared mainly during the first month of treatment.
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How Does Mobile Technology Shape the Perceptions of People with Type 2 Diabetes?
We conducted a randomised clinical trial involving 43 patients diagnosed with type 2 diabetes. For four weeks, participants used the forDiabetes: diabetes self-management mobile app. Using a questionnaire to assess perceptions of the disease, we observed how the use of mobile technology affects perceptions of the disease. We found that participants in the mobile app…
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Efficacy of Non-Ablative Fractional Laser Combined With Tranexamic Acid in Melasma Treatment: A Randomized Split-Face Trial
CONCLUSIONS: The combination of NAFL and topical TXA provides significant short-term clinical benefits in treating melasma, likely by enhancing TXA penetration into target tissues and improving pigmentary clearance. However, its efficacy diminishes over time due to the inevitable recurrence of melasma, necessitating further investigation into long-term maintenance strategies.
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Barriers to Digital Mental Health Services Among College Students
This qualitative study explores barriers to digital mental health Intervention (DMHI) use among college students. Data are from a randomized trial of eBridge, which used motivational interviewing to connect students with mental health concerns to professional care. Thematic analysis of participant feedback on their experience with the DMHI platform revealed nine key obstacles to adoption:…
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Impact of an Evidence-Based Large Language Model (LLM) Diagnostic Decision Support System: A Randomised Controlled Trial
Generative artificial intelligence (AI) influences clinical decision-making in healthcare by analyzing medical data and proposing personalized treatment options based on patient records. However, generative AI limited due to its inability to provide accurate evidence. Therefore, this study aims that the influence of AI-generated diagnostic suggestions on emergency healthcare providers’ diagnostic patterns and decision-making, and evaluates…
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Petal-x Visualization for Lifestyle Change in Patients at Risk of Cardiovascular Diseases: An Evaluation
Cardiovascular diseases (CVDs) are the leading global cause of death and addressing unhealthy lifestyles is essential for reducing CVD risk. Visual explanations, such as the Petal-X dashboard, can support personalized care by improving patients’ understanding of health risks and motivating lifestyle changes. This study evaluated whether the Petal-X dashboard, utilizing the SCORE2 model for 10-year…
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The effect of hope-based counseling on perceived stress and the quality of life in pregnant women experiencing nausea and vomiting: a randomized control trial
CONCLUSION: Counseling based on hope therapy was effective in reducing perceived stress and improving the quality of life for pregnant women experiencing nausea and vomiting. Implementing this approach could be a valuable strategy for health policymakers to enhance the quality of life for pregnant women, particularly those dealing with pregnancy-related nausea and vomiting.