Clinical Trials
Category Added in a WPeMatico Campaign
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Concurrent Treatment of Posttraumatic Stress Disorder and Alcohol Use Disorder in Women: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this trial of integrated treatment vs relapse prevention, integrated treatment led to a greater reduction in PTSD symptom severity and no detectable difference in alcohol use decrease compared with relapse prevention. These results support that integrated treatment can safely and effectively treat PTSD in women with AUD and ongoing alcohol use.
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The hf-PGA is a valid and reliable measure of hand/foot psoriasis severity in adults: results from a phase 2b clinical trial
The objective was to investigate the reliability, validity, and meaningful change scores for the Physician’s Global Assessment of Hands and/or Feet (hf-PGA), a measure of clinician-reported psoriasis severity on the hands/feet. Baseline, Week 8, and Week 16 data were analyzed from adult patients with moderate to severe plaque psoriasis (n = 99) in a Phase…
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Treatment of neuropathic pain in leprosy patients with a physiotherapeutic protocol combined with photobiomodulation
CONCLUSION: This study provides relevant evidence for the efficacy of PPBMG in treating neuropathic pain in leprosy patients.
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Investigating the effect of awareness-raising based on acceptance and commitment therapy on the quality of life of women living with HPV (human papilloma virus)
CONCLUSION: ACT-based awareness-raising may have the potential to enhance the quality of life of women living with HPV. Therefore, it is recommended that health, therapeutic, and behavioural centres use this method to support women with HPV.
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Role of placental extracts in enhancing periodontal flap surgery healing: insights from periostin biomarker analysis
CONCLUSIONS: The adjunctive use of placental extract gel in surgical periodontal therapy demonstrated beneficial effects on healing outcomes. In addition, periostin shows promise as a biomarker for periodontal wound healing.
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Impairment of neck and shoulder function after neck dissection: a comparative study of goniometry, EMG and paper pencil tool in a randomized controlled trial of level IIb preserving verses conventional neck dissection
CONCLUSIONS: The study demonstrates agreement between shoulder function measurements (goniometry and EMG) but discordance with NDII. This discrepancy may arise from the distinct constructs used by NDII to assess neck dissection impairment, highlighting potential limitations in its sensitivity to functional recovery.
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Cardiac index, SvO(2) or pCO(2) gap may determine benefit from ECMO in cardiogenic shock: post-hoc analysis of the multicenter, randomized ECMO-CS trial
CONCLUSIONS: Measurement of cardiac index, pCO(2) gap and SvO(2) could improve the management of cardiogenic shock. The presence of any of the following criteria — low cardiac index, high pCO(2) gap and low SvO(2) — may indicate a poor prognosis with conservative therapy and a substantial mortality benefit from mechanical circulatory support.
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Synergistic Impact of Nasal Irrigation and Health Education in Reducing Chronic Rhinosinusitis Among Cement Plant Workers: a Randomized Controlled Trial
CONCLUSIONS: This study highlights the synergistic potential of health education and nasal irrigation in managing occupational CRS. Nasal irrigation, in particular, emerged as a highly effective, low-cost intervention for alleviating CRS symptoms in high-risk industrial settings. These findings underscore the importance of integrating non-pharmacological approaches into occupational health programs to safeguard respiratory health among workers…
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Interactive CBT for headache and relaxation training (iCHART): Single-arm pilot trial of cognitive behavioral therapy for veterans with post-traumatic headache
BackgroundCognitive behavioral therapy for headache (CBT-HA) improves headache-related outcomes, but accessibility barriers limit its use. This pilot study evaluated the feasibility, acceptability and clinical signal of an interactive voice response (IVR)-delivered CBT-HA intervention for veterans with post-traumatic headache (PTH).MethodsA single-arm pilot trial was conducted with 18 veterans diagnosed with PTH. Participants completed a 10-week IVR-CBT-HA…
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Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease
CONCLUSION: Multiparametric US allows the non-invasive assessment of steatosis, inflammation, and fibrosis in patients with MASLD. Liver viscosity improved the capability of non-invasively identifying patients with MASH.