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Impact of secukinumab with modified nourishing blood and moisturising decoction on superficial fungal infections in patients with psoriasis with blood-dryness pattern
CONCLUSION: In this study, combining secukinumab with a modified nourishing and moisturising TCM regimen yielded superior clinical outcomes, including greater symptom relief, improved quality of life, and a reduced risk of superficial fungal infections compared with biologic monotherapy. →
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A BOPPPS-based micro-lecture teaching intervention for orthopaedic postgraduates in China
BACKGROUND: Orthopaedics is a highly specialized discipline characterized by complex theoretical frameworks and extensive knowledge, posing challenges for postgraduate teaching. With the advancement of educational technology, micro-lectures have been increasingly adopted in medical education. However, their isolated use may be insufficient to sustain student engagement or ensure effective learning. The bridge-in, learning objective, pre-test, participatory… →
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Early essential newborn care for late preterm and term infants delivered by cesarean section: a randomized controlled trial on neonatal hypoglycemia and breastfeeding
CONCLUSION: The EENC improves neonatal glucose regulation and breastfeeding in cesarean-born late preterm and term infants, potentially enhancing neonatal health, maternal-infant bonding, and postpartum transition. →
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Interobserver agreement for the assessment of erosive reflux esophagitis: a post hoc analysis of clinical trial data
Interobserver agreement for the Los Angeles (LA) classification of erosive reflux esophagitis was good in validation studies, but limited agreement data exists from clinical trials (CTs). We conducted a post hoc evaluation of interobserver agreement between CT endoscopists and independent expert adjudicators in a multi-center, randomized controlled trial of a new acid suppression therapy. Trial… →
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Feasibility trial of a transdiagnostic individual lifestyle evaluation and intervention (Lev-i) for health behavior change
CONCLUSION: Findings suggest that Lev-i is a feasible and acceptable intervention for promoting health behaviors among individuals with disabilities. However, further refinements may enhance feasibility for both patients and professionals before conducting a randomized controlled trial. ClinicalTrials.gov (NCT05889936). →
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How to Navigate Rapid Growth
Carolyn Geason-Beissel/MIT SMR | Getty Images In 2019, two Dutch entrepreneurs founded an environmental, social, and governance (ESG) consulting firm with six like-minded friends and former classmates. United by a shared vision to transform their industry, the close-knit team members poured themselves into the venture, working long hours and celebrating every small win. Within a… →
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Lidocaine Gel or Spray During Upper Gastrointestinal Endoscopy: Efficacy and Safety Randomized Controlled Evaluation of Topical Pharyngeal Anesthesia
CONCLUSION: Lidocaine Gel is considered safe, suitable and effective option and exhibiting better performance in reducing the incidence of gag reflex, with the ease of esophageal entrance shortening recovery time and improving patient and endoscopist satisfaction. Decrease total propofol consumption in patients undergoing UGIE compared to lidocaine spray. →
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Comparision of clinical and doppler assisted identification of saphenofemoral junction and peforators in varicose veins patients with intraoperative findings
CONCLUSION: Clinical examination remains dependable for identifying SFJ incompetence; however, Doppler ultrasound provides greater accuracy in detecting perforator incompetence. Incorporating Doppler routinely in preoperative evaluation can improve localization of incompe-tent veins, optimize surgical outcomes, and reduce recurrence rates in varicose vein management. →
