Diana Trujillo-Benítez April 27, 2024 Pharmaceutics. 2024 Apr 12;16(4):532. doi: 10.3390/pharmaceutics16040532. ABSTRACT Recently, we reported a new fibroblast activation protein (FAP) inhibitor radiopharmaceutical based on the 99mTc-((R)-1-((6-hydrazinylnicotinoyl)-D-alanyl) pyrrolidin-2-yl) boronic acid (99mTc-HYNIC-D-Alanine-BoroPro)(99mTc-HYNIC-iFAP) structure for tumor microenvironment SPECT imaging. This research aimed to synthesize 68Ga-[2,2′,2″,2‴-(2-(4-(2-(5-(((S)-1-((S)-2-boronopyrrolidin-1-yl)-1-oxopropan-2-yl)carbamoyl)pyridin-2-yl)hydrazine-1-carbothioamido)benzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid] (68Ga-DOTA-D-Alanine-BoroPro)(68Ga-iFAP) as a novel radiotracer for PET imaging and evaluate its… →
Yasuhiko Komatsu April 27, 2024 Nutrients. 2024 Apr 20;16(8):1230. doi: 10.3390/nu16081230. ABSTRACT A randomized, placebo-controlled, double-blind, parallel-group clinical study was conducted to examine the effects of ingesting a heat-killed lactic acid bacterium, Lactobacillus johnsonii No. 1088 (LJ88) on temporal gastroesophageal reflux-related symptoms in healthy volunteers. A total of 120 healthy Japanese volunteers of both sexes,… →
Ilona Korzonek-Szlacheta April 27, 2024 Nutrients. 2024 Apr 20;16(8):1227. doi: 10.3390/nu16081227. ABSTRACT The burden of cardiovascular disease and the percentage of frail patients in the aging population will increase. This study aims to assess the circulating levels of several cytokines in frail patients. This is an ancillary analysis of the FRAPICA trial. The ratio of… →
Yun-Ah Lee April 27, 2024 Nutrients. 2024 Apr 13;16(8):1155. doi: 10.3390/nu16081155. ABSTRACT An increased homocysteine level is a risk factor for cardiovascular disease, venous thromboembolism, cerebrovascular disease, and chronic kidney disease. In addition, vitamin D deficiency is associated with coronary artery disease and metabolic disorders. The present study included data from 1375 adults (895 men… →
Domingos Roda April 27, 2024 Genes (Basel). 2024 Apr 17;15(4):501. doi: 10.3390/genes15040501. ABSTRACT Glioblastoma, the most aggressive and common malignant primary brain tumour, is characterized by infiltrative growth, abundant vascularization, and aggressive clinical evolution. Patients with glioblastoma often face poor prognoses, with a median survival of approximately 15 months. Technological progress and the subsequent improvement… →
Antonio D’Amato April 27, 2024 Medicina (Kaunas). 2024 Apr 6;60(4):608. doi: 10.3390/medicina60040608. ABSTRACT Background and Objectives: Despite advancements in detection and treatment, cervical cancer remains a significant health concern, particularly among young women of reproductive age. Limited data exists in the literature regarding fertility-sparing treatment (FST) of cervical cancers with tumor sizes greater than 2… →
Matas Nasvytis April 27, 2024 Medicina (Kaunas). 2024 Apr 1;60(4):589. doi: 10.3390/medicina60040589. ABSTRACT GNB1 encephalopathy is a rare genetic disease caused by pathogenic variants in the G Protein Subunit Beta 1 (GNB1) gene, with only around 68 cases documented worldwide. Although most cases had been caused by de novo germline mutations, in this case, the… →
Anna Grenda April 27, 2024 Int J Mol Sci. 2024 Apr 10;25(8):4208. doi: 10.3390/ijms25084208. ABSTRACT Lung cancer has become a major public health concern, standing as the leading cause of cancer-related deaths worldwide. Among its subtypes, small-cell lung cancer (SCLC) is characterized by aggressive and rapid growth, poor differentiation, and neuroendocrine features. Typically, SCLC is… →
Chiara Zanon April 27, 2024 J Clin Med. 2024 Apr 22;13(8):2436. doi: 10.3390/jcm13082436. ABSTRACT Background/Objectives: Advancements in oral imaging technology are continually shaping the landscape of dental diagnosis and treatment planning. Among these, photon-counting computed tomography (PCCT), introduced in 2021, has emerged as a promising, high-quality oral technology. Dental imaging typically requires a resolution beyond… →
Can Yurttas April 27, 2024 J Clin Med. 2024 Apr 21;13(8):2422. doi: 10.3390/jcm13082422. ABSTRACT (1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This prospective, single-arm, open-label clinical trial aimed to assess… →