CONCLUSION: Using pharmacogenetic testing to adjust haloperidol dosage improves therapy tolerability and accelerates the resolution of psychotic symptoms in patients with alcoholic hallucinosis, confirming the feasibility of a personalized approach in psychopharmacotherapy. →
Background: In oral and oropharyngeal squamous cell carcinoma (OSCC, OPSCC), frequent inadequate surgical margins highlight the importance of precise intraoperative identification and delineation of cancerous tissue for improving patient outcomes. Methods: A prospective, open-label, single-center, single dose, exploratory phase II clinical trial (EudraCT 2022-001361-12) to assess the efficacy of the novel uPAR-targeting near-infrared imaging agent,… →
CONCLUSIONS: Replacing SMS text messages with reminder letters did not increase the participation rate but also led to a decline in participation among nonparticipants 6 weeks after the invitation. However, sending a second reminder by letter significantly increased participation rates among nonparticipants within 6 weeks in the SMS text message group compared with those who… →
Generative language models face persistent challenges when transitioning from training to practical application. One significant difficulty lies in aligning these models to perform optimally during inference. Current methods, such as Reinforcement Learning from Human Feedback (RLHF), focus on improving win rates against a baseline model. However, they often overlook the role of inference-time decoding strategies… →
AI agents have become an integral part of modern industries, automating tasks and simulating complex systems. Despite their potential, managing multiple AI agents, especially those with diverse roles, can be challenging. Developers often face issues such as inefficient communication protocols, difficulties in maintaining agent states, and limited scalability in large-scale setups. Additionally, generating synthetic data… →
Graph Neural Networks GNNs have become a powerful tool for analyzing graph-structured data, with applications ranging from social networks and recommendation systems to bioinformatics and drug discovery. Despite their effectiveness, GNNs face challenges like poor generalization, interpretability issues, oversmoothing, and sensitivity to noise. Noisy or irrelevant node features can propagate through the network, negatively impacting… →
Background: Coronary angiography, an invasive diagnostic procedure, often induces pain and anxiety in patients. Despite the potential for alleviating discomfort, the use of stress balls as a nonpharmacological intervention during angiography remains underexplored. Objective: This study is aimed at investigating the impact of stress ball application on pain and anxiety levels in patients undergoing angiography.… →
Objective: To observe the effects of cardiac rehabilitation guided by cardiopulmonary exercise testing (CPET) on cardiorespiratory reserve function, blood pressure, blood pressure variability, and lipid metabolism in patients with hypertension. Methods: A randomized trial enrolled 67 Grade 1 hypertensive patients on antihypertensive drugs, divided into conventional (n = 35) and CPET (n = 32) groups.… →