CONCLUSIONS AND RELEVANCE: In this prespecified secondary analysis of a randomized clinical trial of ADT plus AAP, APA alone, or APA plus AAP for patients with advanced CSPC, HRQOL was not statistically different between treatments with APA alone or APA plus AAP as compared with ADT plus AAP. Larger studies with longer follow-up and more… →
Atrophic acne scars present a significant therapeutic challenge. While subcision with various adjunctive treatments, including fractional CO₂ lasers and polydioxanone (PDO) threads, has been employed for scar remodeling, comparative evidence on their efficacy remains limited. This study aims to compare the clinical efficacy and patient satisfaction between subcision with fractional CO₂ laser and subcision with… →
CONCLUSION: The use of a multidisciplinary rehabilitation approach, including nutritional support, magnetic therapy and psychological assistance, demonstrates a significant improvement in symptom management and quality of life in patients with melanoma after surgical treatment. →
Artificial Intelligence (AI) has made significant strides in various fields, including healthcare, finance, and education. However, its adoption is not without challenges. Concerns about data privacy, biases in algorithms, and potential job displacement have raised valid questions about its societal impact. Additionally, the “black box” nature of many AI systems makes it difficult to understand… →
Developing Graphical User Interface (GUI) Agents faces two key challenges that hinder their effectiveness. First, existing agents lack robust reasoning capabilities, relying primarily on single-step operations and failing to incorporate reflective learning mechanisms. This usually leads to errors being repeated in the execution of complex, multi-step tasks. Most current systems rely very much on textual… →
Large reasoning models are developed to solve difficult problems by breaking them down into smaller, manageable steps and solving each step individually. The models use reinforcement learning to enhance their reasoning abilities and develop very detailed and logical solutions. However, while this method is effective, it has its challenges. Overthinking and error in missing or… →
This is a randomized, double-blind, placebo-controlled phase 3 clinical trial (ClinicalTrials.gov, NCT04878016) conducted in 54 hospitals in China. Adults who were histologically diagnosed and never treated for extensive-stage small cell lung cancer (ES-SCLC) were enrolled. Eligible Patients were randomly assigned (1:1) to receive four cycles (21 days as one cycle) of intravenous carboplatin (area under… →