Methotrexate injections intralesionally as a treatment for psoriatic nails proved to be effective in large-scale studies as well as individual case reports, but the process is painful and time-consuming. The objective of this study was to compare the efficacy and safety of combined fractional CO2 laser (Fr. CO2) 10,600 nm and methotrexate gel versus methotrexate… →
Modern data programming involves working with large-scale datasets, both structured and unstructured, to derive actionable insights. Traditional data processing tools often struggle with the demands of advanced analytics, particularly when tasks extend beyond simple queries to include semantic understanding, ranking, and clustering. While systems like Pandas or SQL-based tools handle relational data well, they face… →
Agentic AI systems are fundamentally reshaping how tasks are automated, and goals are achieved in various domains. These systems are distinct from conventional AI tools in that they can adaptively pursue complex goals over extended periods with minimal human supervision. Their functionality extends to tasks requiring reasoning, such as managing logistics, developing software, or even… →
Computer vision models have made significant strides in solving individual tasks such as object detection, segmentation, and classification. Complex real-world applications such as autonomous vehicles, security and surveillance, and healthcare and medical Imaging require multiple vision tasks. However, each task has its own model architecture and requirements, making efficient management within a unified framework a… →
AI alignment ensures that AI systems consistently act according to human values and intentions. This involves addressing the complex challenges of increasingly capable AI models, which may encounter scenarios where conflicting ethical principles arise. As the sophistication of these models grows, researchers are dedicating efforts to developing systems that reliably prioritize safety and ethical considerations… →
Molecule discovery is important in various scientific research fields, particularly pharmaceuticals and materials science. While the emergence of Graph Neural Networks (GNNs) has revolutionized this field by enabling the representation of molecules as graphs and facilitating property predictions, it faces difficulties in generalizing across different tasks, requiring substantial task-specific data collection. These approaches show limitations… →
Aging is linked to a significant rise in neurodegenerative diseases like Alzheimer’s and cognitive decline. While brain aging involves complex molecular and cellular changes, our understanding of these processes within their spatial context remains limited. Past studies have provided valuable insights into age-related brain changes at a single-cell level but lack comprehensive spatiotemporal resolution. High-throughput… →
Increasing mental health problems among university students highlight the need for scalable, effective solutions. We have developed a transdiagnostic mobile intervention called ROOM, promoting adaptive emotion regulation (ER) skills among university students. Understanding how the intervention works and optimising content and delivery is essential for creating an effective and adaptive system. Therefore, this study aimed… →
CONCLUSION: Efforts to increase male enrollment in behavioral clinical trials will benefit from a focus on early stages of recruitment, aiming to increase potential participants’ initial levels of interest and awareness of their health risk. As men and women differ in the reasons they choose to participate in a behavioral trial, recruitment should be tailored… →
CONCLUSIONS: The 12-week study of the Active Break intervention for young people with non-specific low back pain demonstrated significant improvement. Our research offers valuable evidence-based practices for managing and preventing low back pain, benefiting individuals, educators, healthcare professionals, personal trainers, and family physicians. →