CONCLUSION: Lebrikizumab-treated patients with moderate-to-severe AD showed improved symptoms and QoL across EASI response categories at W16, with greater improvements observed in patients with higher EASI responses. →
The development of Physical AI—AI systems designed to simulate, predict, and optimize real-world physics—has long been constrained by significant challenges. Building accurate models often demands extensive computational resources and time, with simulations sometimes requiring days or weeks to produce actionable results. Additionally, the complexity of scaling these systems for practical use across industries such as… →
Dense embedding-based text retrieval has become the cornerstone for ranking text passages in response to queries. The systems use deep learning models for embedding text into vector spaces that enable semantic similarity measurements. This method has been adopted widely in applications such as search engines and retrieval-augmented generation (RAG), where retrieving accurate and contextually relevant… →
BACKGROUND: Sarcopenia is a clinical syndrome characterized by the loss of muscle mass and strength. Hormonal changes that occur early in women may influence protein synthesis and promote muscle atrophy, leading to probable sarcopenia, defined as a loss of muscle strength without an obvious decrease in muscle mass. Various types of exercise have already proven… →
CONCLUSIONS: This 3-year updated analysis confirms the sustained efficacy of atezolizumab in combination of bevacizumab in patients with advanced mucosal melanoma. Inflammatory cell infiltration and angiogenic status were associated with therapeutic response. Furthermore, mucosal melanoma of upper site and NRAS mutation appear to be good predictors of response to immune checkpoint inhibitor and anti-angiogenic combination… →
CONCLUSION: Exposure to hypoxia led to RVFWS impairment in more than one quarter of patients with COPD. Strain analysis is a promising, non-invasive method for evaluating RV dysfunction, even in subclinical cases and might be prognostically relevant in patients with lung diseases. →
BACKGROUND: Brain metastases are a common complication in patients with non-small-cell lung cancer (NSCLC) lacking actionable driver mutations, with limited treatment options and poor prognosis. We aimed to investigate the efficacy and safety of brain radiotherapy combined with camrelizumab and platinum-doublet chemotherapy in patients with newly diagnosed advanced NSCLC and brain metastases. →
The increasing prevalence of diabetes mellitus worldwide necessitates that medical undergraduates acquire a deep understanding of the disease to ensure accurate diagnosis and effective management. Traditional teaching methods, while foundational, often lack the interactive elements that enhance student engagement and knowledge retention. This study aimed to evaluate the effectiveness of a novel educational board game,… →
Early therapeutic intervention in high-risk smoldering multiple myeloma (HR-SMM) has shown benefits, however, no studies have assessed whether biochemical progression or response depth predicts long-term outcomes. The single-arm I-PRISM phase II trial (NCT02916771) evaluated ixazomib, lenalidomide, and dexamethasone in 55 patients with HR-SMM. The primary endpoint, median progression-free survival (PFS), was not reached (NR) (95%… →
In a time when global health faces persistent threats from emerging pandemics, the need for advanced biosurveillance and pathogen detection systems is increasingly evident. Traditional genomic analysis methods, while effective in isolated cases, often struggle to address the complexities of large-scale health monitoring. A significant challenge is identifying and understanding the genomic diversity in environments… →