CONCLUSIONS: Letrozole treatment produced an effective growth response, particularly in DCIS initially classified as luminal A. Study inclusion criteria of DCIS with at least 1% ER positive cells resulted in the inclusion of other subtypes that failed to respond. Treatment also induced both minor and major changes in intrinsic subtype based on PAM50 probabilities. Overall,… →
CONCLUSIONS: This confirms the effectiveness of proposed method and opens up further prospects for the updated function of the IAN following the BSSO. →
CONCLUSION: Preliminary evidence indicates that a two-session, patient-centred, peer-cofacilitated psychoeducational programme is feasible and well-received, with high ratings for satisfaction from outpatients and caregivers. CLINICLATRIALS. →
BACKGROUND: The discovery of cellular tumor networks in glioblastoma, with routes of malignant communication extending far beyond the detectable tumor margins, has highlighted the potential of supramarginal resection strategies. Retrospective data suggest that these approaches may improve long-term disease control. However, their application is limited by the proximity of critical brain regions and vasculature, posing… →
Mathematical Large Language Models (LLMs) have demonstrated strong problem-solving capabilities, but their reasoning ability is often constrained by pattern recognition rather than true conceptual understanding. Current models are heavily based on exposure to similar proofs as part of their training, confining their extrapolation to new mathematical problems. This constraint restricts LLMs from engaging in advanced… →
Large language models (LLMs) use extensive computational resources to process and generate human-like text. One emerging technique to enhance reasoning capabilities in LLMs is test-time scaling, which dynamically allocates computational resources during inference. This approach aims to improve the accuracy of responses by refining the model’s reasoning process. As models like OpenAI’s o1 series introduced… →
Hypothesis validation is fundamental in scientific discovery, decision-making, and information acquisition. Whether in biology, economics, or policymaking, researchers rely on testing hypotheses to guide their conclusions. Traditionally, this process involves designing experiments, collecting data, and analyzing results to determine the validity of a hypothesis. However, the volume of generated hypotheses has increased dramatically with the… →
CONCLUSIONS: US-guided TPVB had a higher success rate of upper extremity sympathetic blockade than US-guided SGB, with more pronounced immediate postprocedural pain relief. →