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Efficacy of acupuncture at pain-sensitive acupoints for diarrhoea-predominant irritable bowel syndrome (IBS-D): protocol of a multicentre, randomised, sham-controlled trial
INTRODUCTION: While recent research suggests that acupuncture may offer benefits to individuals with diarrhoea-predominant irritable bowel syndrome (IBS-D), high-quality studies are scarce in this area. We intend to investigate the efficacy and safety of individualised sensitised acupuncture in IBS-D. →
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Molecular monitoring versus standard clinical care in younger adults with acute myeloid leukaemia: results from the UK NCRI AML17 and AML19 randomised, controlled, phase 3 trials
BACKGROUND: In patients with acute myeloid leukaemia treated with curative intent, the detection of measurable residual disease (MRD) generally confers a poor prognosis. This study aimed to identify whether altering treatment based on MRD results can improve survival. →
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ABB Robotics vs Inovako: Which AI Solution Automates Production Best?
ABB Robotics automates complex manufacturing tasks enabling mass customization and faster production Lowering labor costs and minimizing defects by 20% reduces operational expenses Equivalent products from the list include Inovako or Cognizant AI Solutions →
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Potential Harms of Feedback After Web-Based Depression Screening: Secondary Analysis of Negative Effects in the Randomized Controlled DISCOVER Trial
CONCLUSIONS: The results indicate that feedback after web-based depression screening is not associated with negative effects such as misdiagnosis, mistreatment, and deterioration in depression severity or in emotional response to symptoms. However, it cannot be ruled out that nontailored feedback may increase the risk of deterioration in suicidal ideation. Robust prospective research on negative effects… →
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Intertrigo in Severe Obesity: Clinical Insights and Outcomes With a New Antimicrobial Silver-Infused Breathable Fabric
CONCLUSIONS: We underline the need for intertrigo screening in patients with obesity, especially in those with risk factors, such as female, older, and higher BMI. The use of a novel MWF effectively alleviates symptoms within a short treatment period and should be considered as an optional intertrigo treatment. →
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Effect of Oral Insulin on Early Combined Glucose and C-Peptide Endpoints in Individuals at High-Risk for Type 1 Diabetes
Background: The TrialNet Oral Insulin (OI) prevention trial showed no overall treatment effect, using the diagnosis of type 1 diabetes as an endpoint. A significant delay in onset was only found in a high-risk stratum (termed secondary stratum 1) of participants with low first-phase insulin release (FPIR). Methods: Since trials with an endpoint of type… →
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Predicting treatment outcome for complex posttraumatic stress disorder using the personalized advantage index
ABSTRACTBackground: Ample studies have demonstrated the effectiveness of psychotherapy for posttraumatic stress disorder (PTSD). However, large individual variation in treatment outcome remains unsolved and treatment options for complex posttraumatic stress disorder (CPTSD) are debated. There is a need for exploring methods for matching patients with treatment they will most likely benefit from.Objective: To develop a… →
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Phase II Study to Evaluate the Safety and Efficacy of Neoadjuvant Chemotherapy with Weekly Paclitaxel and Carboplatin Followed by Radical Chemoradiation in Locally Advanced Cervical Cancer in Egyptian Population
CONCLUSION: NACT with dose dense protocol, followed by CCRT, is a treatment option for locally advanced cervical cancer with controllable adverse events and agood response rate. →
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Image Filtering using Convolution in OpenCV
Image filtering is one of the fundamental building blocks of computer vision. Whether you’re smoothing an image to remove noise or enhancing features for better detection, filtering techniques based on convolution are everywhere. In this article, we’ll explore image filtering using convolution — understanding the mathematics behind it, and seeing how it’s practically implemented in… →
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Prospective phase II trial of first-line rituximab, methotrexate, and orelabrutinib (R-MO) in primary central nervous system lymphoma
The treatment of primary central nervous system lymphoma (PCNSL) is currently limited by the impermeability of the blood-brain barrier. This study aims to assess the efficacy and safety of the R-MO regimen (rituximab, high-dose methotrexate, and orelabrutinib) in the treatment of patients with newly diagnosed PCNSL. A total of 37 patients were enrolled in this… →
