To confirm transcatheter arterial chemoembolization (TACE) combined with apatinib for advanced perihilar cholangiocarcinoma (PCC) is effective and safe. A comprehensive treatment plan involving TACE combined with targeted therapy was implemented for the patients with pathologically diagnosed advanced PCC, where TACE was performed every 4-6 weeks to deliver albumin paclitaxel and gemcitabine for a maximum of… →

We use machine learning to identify innovative strategies to target azithromycin to the children with watery diarrhea who are most likely to benefit. Using data from a randomized trial of azithromycin for watery diarrhea (NCT03130114), we develop personalized treatment rules given sets of diagnostic, child, and clinical characteristics, employing a robust ensemble machine learning-based procedure.… →

Objective: To explore the effects of the «group+individual» combined internet occupational health management model on the physiological indicators, pulmonary imaging changes and self-management ability of people with pneumoconiosis. Methods: In November 2022, patients diagnosed with pneumoconiosis in Baotou city from January 2012 to January 2022 were selected. Eighty cases exhibiting a decline in forcect expiratory… →

CONCLUSION: Molecular subtype and DDR alterations did not correlate with improved outcomes in CALGB 90601. Possible explanations for these results include the small cohort size, lack of strong therapeutic effects of the treatments, genomic heterogeneity between profiled specimens and the metastatic lesions under treatment pressure, and differences in biology associated with different disease states (muscle-invasive… →

CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the prescribed digital migraine health app did not show superiority in reducing migraine days compared with a control app having only basic headache documentation features. This finding underscores the need for randomized clinical trials as a cornerstone of a robust evaluation framework, ensuring both treatment efficacy and… →

CONCLUSIONS: The VAMP confirmed the presence of a painful vestibule, PFM, and paraurethra under pressure. The VAMP protocol was successfully cross-validated and effective in discriminating women with PFM overactivity, confirmed in almost all patients with vulvodynia. Half of the participants met the criteria for CS. The correlation between CSI and PFM pain on pressure suggests… →

CONCLUSION: Efficacy and safety in the Japan subset were generally consistent with outcomes in the DUO-E ITT population. This Japanese subset analysis of DUO-E supports carboplatin/paclitaxel + durvalumab followed by durvalumab with or without olaparib as new treatment options in patients with advanced or recurrent endometrial cancer and is the first to report on these… →

CONCLUSIONS: Our study demonstrated that both oral TXA combined with hydroquinone cream and oral TXA combined with Cordyceps essence significantly improved melasma in women. However, the incidence of adverse reactions was lower with topical Cordyceps essence than that with hydroquinone cream. Cordyceps essence appeared to be a promising alternative for patients intolerant to hydroquinone cream.… →