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Efficacy of methylprednisolone sodium succinate combined with acoustic resonance therapy on inflammatory response indicators and cerebral microcirculation in patients with sudden sensorineural hearing loss
CONCLUSION: The findings suggest that the synergistic application of MPSS and acoustic resonance therapy effectively reduces inflammation and improves cerebral blood flow, leading to better auditory outcomes in patients with SSNHL. This research underscores the potential of integrated treatment approaches in managing SSNHL. →
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Effectiveness of an online sexual and reproductive health educational program on knowledge, attitudes, and behaviours among senior primary school students: a cluster randomized controlled trial
CONCLUSIONS: The online sexual and reproductive health educational program significantly improved knowledge, attitudes, and behaviours among senior primary students, providing valuable guidance for school health nurses in designing and implementing sexual and reproductive health education programs. →
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Effect of different administration methods of dexamethasone on postoperative pain and swelling following implant flap surgery: A randomized controlled trial of patient-centered outcomes
CONCLUSIONS: Intraoperative submucosal dexamethasone was associated with earlier swelling reduction compared to oral administration, though both methods showed comparable pain control. These findings suggest a potential clinical advantage for the intraoperative route that warrants further investigation. →
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Levels of peripheral CD4 + and CD8 + T cells and glycaemic control level in patients with both type 2 mellitus diabetes and stage III-IV periodontitis: a randomized controlled trial in Chinese population
CONCLUSION: Participants under hyperglycemia (HbA1c ≥ 7.5%) and stage III-IV periodontitis exhibited higher sensitivity of HbA1c level to SRP treatment. When HbA1c ≥ 7.5%, The peripheral CD4+/CD8 + ratio showed a slight increase in the intervention group while only reduction was found in other groups. And the peripheral CD4+/CD8 + ratio of SRP + OHI… →
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Influences of social support following hip-fracture surgery for older adults with cognitive impairment and their family caregivers
CONCLUSIONS: Good perceived social support positively influenced recovery trajectories for older adults with cognitive impairment and improved HRQoL for both care receivers and caregivers, highlighting the importance of developing targeted interventions to enhance social support during post-surgical recovery for this vulnerable population. →
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Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema
CONCLUSION: Combined SCTA using this modified custom needle with topical nepafenac 0.3% resulted in better anatomical and functional results in PCME patients compared to topical nepafenac 0.3% alone. The study was prospectively registered with clinical trial.gov ID (NCT04690608) in 27-12-2020. →
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Impact of wearable-assisted walking on sarcopenia and body composition in older adults
CONCLUSIONS: Wearable devices, such as smartwatches and fitness trackers, provide real-time feedback and enable tailored exercise recommendations, offering a practical and personalized strategy for mitigating sarcopenia. This study confirms that wearable-assisted walking programs effectively improve muscle health and functional performance in older adults, reinforcing their potential for promoting healthy aging. →
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DeepSeek R1T2 Chimera: 200% Faster Than R1-0528 With Improved Reasoning and Compact Output
«`html DeepSeek R1T2 Chimera: 200% Faster Than R1-0528 With Improved Reasoning and Compact Output TNG Technology Consulting has unveiled DeepSeek-TNG R1T2 Chimera, a new Assembly-of-Experts (AoE) model that blends intelligence and speed through an innovative model merging strategy. Built from three high-performing parent models—R1-0528, R1, and V3-0324—R1T2 demonstrates how expert-layer interpolation at scale can unlock… →
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Building a BioCypher-Powered AI Agent for Biomedical Knowledge Graph Generation and Querying
«`html Building a BioCypher-Powered AI Agent for Biomedical Knowledge Graph Generation and Querying This tutorial implements the BioCypher AI Agent, a powerful tool designed for building, querying, and analyzing biomedical knowledge graphs using the BioCypher framework. By combining the strengths of BioCypher, a high-performance, schema-based interface for biological data integration, with the flexibility of NetworkX,… →
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Nicotine e-cigarettes for smoking cessation following discharge from smoke-free inpatient alcohol and other drug withdrawal services: a pragmatic two-arm, single-blinded, parallel-group, randomised controlled trial
BACKGROUND: Nicotine-containing electronic cigarettes (e-cigarettes) have been shown to be effective for smoking cessation among general populations, but there is little evidence in people with substance use disorders (SUDs). We aimed to assess the effectiveness of e-cigarettes for smoking abstinence in people with SUD following discharge from smoke-free inpatient withdrawal services. →
