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Dextrose prolotherapyeffectin improving thetemporomandibular joint disc displacement symptoms without reduction refractory to conservative treatment: a pilot study
This study aimed to evaluate the efficacy of intra-articular injection of 5% Dextrose (D5W) prolotherapy in treatment symptoms of Temporomandibular Joint (TMJ) Disc Displacement without Reduction (DDwoR) with limited mouth opening (Closed-Lock) of patients’refractory to pharmacological and physical therapy. This pilot study included twenty female patients suffering from symptoms of DDwoR with limited mouth opening… →
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Efficacy and safety of combining tislelizumab with capecitabine compared to capecitabine alone in the adjuvant treatment of biliary tract cancers: rationale and protocol design for a randomized clinical trial
BACKGROUND: Adjuvant therapy with capecitabine is recommended to improve survival for resectable biliary tract cancers (BTC) patients. Considering that the combination of PD-1/PD-L1 inhibitors with chemotherapy has demonstrated a survival benefit over chemotherapy alone in advanced stage BTC, we aim to evaluate the treatment efficacy and safety of tislelizumab, a PD-1 inhibitor, combined with capecitabine… →
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My patient might be depressed — can I still screen for MCI? Exploring cognitive performance on the MoCA in older people screened for depressive symptoms with the PHQ-9
CONCLUSION: Cognitive screening with the MoCA seems to be robust against depression and could therefore be used to screen for MCI regardless of depression level. →
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Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
CONCLUSIONS: In this pilot study, the FDDA, a structured diagnostic aid for guiding PCPs in identifying the causes of unexplained fatigue in their patients, was not able to show a global improvement in patient outcomes despite improvements in fatigue and satisfaction with care. The evaluation of fatigue in larger-scale studies is warranted. →
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Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial
Pediatric major depressive disorder (MDD) represents a leading cause of disability worldwide in children and adolescents, while its underlying pathophysiology remains largely elusive. The endocannabinoid system (ECS) and the hypothalamus-pituitary-adrenal (HPA) axis are considered intertwined regulatory systems crucially implicated in the pathophysiology of depressive disorders. This study explores the cross-sectional and longitudinal association between the… →
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Tislelizumab as adjuvant therapy following endoscopic surgery for resectable recurrent nasopharyngeal carcinoma: a randomized clinical trial
CONCLUSIONS: Tislelizumab as adjuvant therapy significantly enhanced PFS and PFI, with a favorable safety profile. Longer follow-up is necessary to determine whether this regimen can be considered as the standard of care for patients with resectable rNPC following endoscopic surgery. →
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Assessing water-assisted colonoscopy in beginner endoscopists: a randomised controlled trial
CONCLUSION: WAC is a safe and effective alternative to CC for novice endoscopists, with similar procedure times, learning curves and safety profiles. These findings support the inclusion of WAC in gastroenterology training programmes. →
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Step-by-Step Guide to Creating Synthetic Data Using the Synthetic Data Vault (SDV)
«`html Step-by-Step Guide to Creating Synthetic Data Using the Synthetic Data Vault (SDV) Real-world data is often costly, messy, and limited by privacy rules. Synthetic data offers a solution and is already widely used in various applications such as training large language models (LLMs) with AI-generated text, simulating edge cases for fraud detection systems, and… →
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NVIDIA Releases Llama Nemotron Nano 4B: An Efficient Open Reasoning Model Optimized for Edge AI and Scientific Tasks
NVIDIA Releases Llama Nemotron Nano 4B: An Efficient Open Reasoning Model Optimized for Edge AI and Scientific Tasks Introduction NVIDIA has launched the Llama Nemotron Nano 4B, an open-source reasoning model tailored for strong performance and efficiency across various scientific tasks, programming, symbolic math, function calling, and instruction following. With only 4 billion parameters, it… →