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Intertrigo in Severe Obesity: Clinical Insights and Outcomes With a New Antimicrobial Silver-Infused Breathable Fabric
CONCLUSIONS: We underline the need for intertrigo screening in patients with obesity, especially in those with risk factors, such as female, older, and higher BMI. The use of a novel MWF effectively alleviates symptoms within a short treatment period and should be considered as an optional intertrigo treatment. →
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Effect of Oral Insulin on Early Combined Glucose and C-Peptide Endpoints in Individuals at High-Risk for Type 1 Diabetes
Background: The TrialNet Oral Insulin (OI) prevention trial showed no overall treatment effect, using the diagnosis of type 1 diabetes as an endpoint. A significant delay in onset was only found in a high-risk stratum (termed secondary stratum 1) of participants with low first-phase insulin release (FPIR). Methods: Since trials with an endpoint of type… →
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Predicting treatment outcome for complex posttraumatic stress disorder using the personalized advantage index
ABSTRACTBackground: Ample studies have demonstrated the effectiveness of psychotherapy for posttraumatic stress disorder (PTSD). However, large individual variation in treatment outcome remains unsolved and treatment options for complex posttraumatic stress disorder (CPTSD) are debated. There is a need for exploring methods for matching patients with treatment they will most likely benefit from.Objective: To develop a… →
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Phase II Study to Evaluate the Safety and Efficacy of Neoadjuvant Chemotherapy with Weekly Paclitaxel and Carboplatin Followed by Radical Chemoradiation in Locally Advanced Cervical Cancer in Egyptian Population
CONCLUSION: NACT with dose dense protocol, followed by CCRT, is a treatment option for locally advanced cervical cancer with controllable adverse events and agood response rate. →
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Image Filtering using Convolution in OpenCV
Image filtering is one of the fundamental building blocks of computer vision. Whether you’re smoothing an image to remove noise or enhancing features for better detection, filtering techniques based on convolution are everywhere. In this article, we’ll explore image filtering using convolution — understanding the mathematics behind it, and seeing how it’s practically implemented in… →
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Prospective phase II trial of first-line rituximab, methotrexate, and orelabrutinib (R-MO) in primary central nervous system lymphoma
The treatment of primary central nervous system lymphoma (PCNSL) is currently limited by the impermeability of the blood-brain barrier. This study aims to assess the efficacy and safety of the R-MO regimen (rituximab, high-dose methotrexate, and orelabrutinib) in the treatment of patients with newly diagnosed PCNSL. A total of 37 patients were enrolled in this… →
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Deepfake Detection with Computer Vision
Imagine this! A video of a world leader giving a speech they never actually delivered, or a celebrity appearing to endorse a product they’ve never even heard of. These aren’t simple photo edits—deepfakes are hyper-realistic, AI-generated videos, images, or audio clips that manipulate reality in ways previously reserved for science fiction. For example, a recent deepfake… →
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An internet-delivered psychoeducational intervention (Fex-Can 2.0) targeting fertility-related distress and sexual dysfunction in young adults diagnosed with cancer: Study protocol of a randomized controlled trial with an internal pilot phase
CONCLUSIONS: This randomized controlled trial aims to evaluate whether Fex-Can 2.0 is superior to standard care, in terms of reducing fertility-related distress and sexual dysfunction in young adults diagnosed with cancer. If proven efficacious, the Fex-Can 2.0 intervention may be a valuable resource in health care, with the potential to significantly improve the care of… →
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Reliability and Acute Changes in the Load-Velocity Profile During Countermovement Jump Exercise Following Different Velocity-Based Resistance Training Protocols in Recreational Runners
This study aimed (i) to explore the reliability of the load-velocity relationship variables (load-axis intercept [L(0)], velocity-axis intercept [v(0)], and the area under the load-velocity relationship line [A(line)]) obtained during the countermovement jump exercise in successive sessions and (ii) to examine the feasibility of the load-velocity relationship variables to detect acute changes in the lower-body… →
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GTM 144: How AI is Rewriting Product and GTM Playbooks | with Oji Udezue (CPO – Typeform, Calendly)
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Oji Udezue was most recently Chief Product Officer at Typeform, where he led product strategy across the company’s growing suite of tools. Previously, he was CPO at Calendly, where he helped scale one of the most beloved PLG tools in the… →