Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal fluid (CSF) Aβ42/40. However, these biomarkers measure brain Aβ deposits indirectly and/or incompletely. In contrast, neuropathologic assessments allow direct investigation of treatment effects on brain Aβ deposits-and on potentially… →

CONCLUSION: Baseline biomarkers, such as K2C5, ENTP6, and CRK, may serve as predictors of clinical improvement in AD patients treated with Nu0.5, highlighting the potential for personalized treatment strategies. Further research is required to validate these findings in larger patient cohorts. →

CONCLUSION: According to the study, patients with limited local invasion gastric adenocarcinoma who are eligible for surgery may benefit more from the FLOT neoadjuvant regimen than the mDCF regimen. The FLOT regimen proves to be more efficient and has fewer complications. →

CONCLUSIONS: The simulation-based breast health education intervention for Afghan refugee women was found to be a practical and innovative approach to raising breast cancer awareness and providing breast self-examination skills. This intervention may play a significant role in identifying at-risk individuals and raising their awareness. If sustained, this could potentially increase future screening participation and… →

CONCLUSIONS: Comorbid depression is associated with a significantly higher risk of 1-year mortality in patients with advanced cancer who exhibit lower levels of proactive positivity, but not in those with higher levels of proactive coping. These findings highlight the importance of incorporating assessments of psychological resilience and coping strategies into the clinical management of advanced… →

CONCLUSIONS: Systemic zinc supplementation combined with topical corticosteroid can be used as an adjunct therapy for OLP management. Topical corticosteroid supplemented with vitamin D has comparable effect to topical corticosteroid alone on pain and clinical improvement in symptomatic OLP. →

Clostridioides difficile infection (CDI) is a significant cause of hospital-acquired diarrhea, leading to high morbidity, recurrence, and healthcare costs. Probiotics like Saccharomyces boulardii show potential as an adjunct therapy to standard CDI treatment, but further trials are needed to confirm their efficacy. This study assessed the efficacy and safety of S. boulardii combined with vancomycin… →