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Interventional arterial chemotherapy versus sorafenib for advanced hepatocellular carcinoma in China: a health economic evaluation of open-label, randomised, phase 3 study
CONCLUSIONS: HAIC-FO is a more cost-effective treatment for advanced HCC than sorafenib from the Chinese payer’s perspective, particularly in patients with Vp4 PVTT and/or high tumour burden. Further research is needed to explore long-term economic implications and real-world effectiveness data. →
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Nobel Laureate Busts the AI Hype
Nobel Prize-winning economist Daron Acemoglu challenges the AI revolution narrative with surprising data: AI will likely automate just 5% of tasks and add only 1% to global GDP this decade. And where the internet’s potential was clear early on, AI’s is not, and the technology has yet to deliver applications that can transform production or… →
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When Experts Pivot, They Pay a Price
For some of us, the rapid rise of artificial intelligence might not seem the least bit worrisome. We’re learning about it and testing it. And we’re slowly but surely integrating the new technology into our lives and work. In other words, we’re adapting—just as we did with the emergence of the internet and smartphones and… →
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Podcast: When a Healthcare Expert Becomes a Patient
When healthcare economist David Dranove noticed blood in his urine, he wasn’t immediately concerned: hematuria had several causes, many of which were benign. Dranove, a professor of strategy at Kellogg, would later learn he had bladder cancer. Seeking treatment was anything but simple—which, for a healthcare economist, speaks volumes about the complexity of the market.… →
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This AI Paper Introduces WEB-SHEPHERD: A Process Reward Model for Web Agents with 40K Dataset and 10× Cost Efficiency
WEB-SHEPHERD: A Process Reward Model for Web Agents Web navigation involves training machines to interact with websites for tasks like searching for information, shopping, or booking services. Developing effective web navigation agents is challenging due to the need for understanding website structures, interpreting user goals, and making sequential decisions. Moreover, agents must adapt to dynamic… →
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National University of Singapore Researchers Introduce Dimple: A Discrete Diffusion Multimodal Language Model for Efficient and Controllable Text Generation
National University of Singapore Researchers Introduce Dimple: A Discrete Diffusion Multimodal Language Model for Efficient and Controllable Text Generation In recent months, there has been increasing interest in applying diffusion models, originally designed for continuous data like images, to natural language processing (NLP) tasks. This has led to the development of Discrete Diffusion Language Models… →
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Twenty-year outcomes after repeat doses of antenatal corticosteroids prior to 32 weeks’ gestation: Follow-up of a randomised clinical trial
CONCLUSIONS: In this follow-up of a randomised clinical trial, our data suggest neither major harm nor benefit for the offspring in early adulthood following exposure to repeat dose(s) of antenatal corticosteroids compared with a single course prior to 32 weeks’ gestation. Smaller effects cannot be excluded and follow-up of adult offspring from other trials of… →
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Incorrect Answers Improve Math Reasoning? Reinforcement Learning with Verifiable Rewards (RLVR) Surprises with Qwen2.5-Math
Incorrect Answers Improve Math Reasoning? Reinforcement Learning with Verifiable Rewards (RLVR) Surprises with Qwen2.5-Math In natural language processing (NLP), reinforcement learning (RL) methods, such as reinforcement learning with human feedback (RLHF), have been used to enhance model outputs by optimizing responses based on feedback signals. A specific variant, reinforcement learning with verifiable rewards (RLVR), extends… →
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Impact of maintenance treatment on male gonadal function in patients treated for localized rhabdomyosarcoma in RMS2005 trial in France
CONCLUSIONS: Oral-CPM induces additional gonadal damage to the ifosfamide-based induction regimen. Fertility preservation could be considered in patients exposed to maintenance, especially those >5 years old and exposed to ≥12 months of oral-CPM. →
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Core Exercise as Non-Pharmacological Strategy for Improving Metabolic Health in Prediabetic Women
Background and Objectives: Prediabetes (PD) is characterized by impaired glucose metabolism and is associated with an elevated risk of type 2 diabetes and cardiovascular diseases. This study aimed to investigate the effects of an 8-week core exercise intervention on glycemic control, lipid profiles, insulin sensitivity, body composition, and physical performance in prediabetic women. Materials and… →
