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  • Impact of Providing an Automated Telephone Option to Report Weekly Patient-Reported Outcome Measures in the PRO-TECT Trial (AFT-39) on Disparity Gaps in Symptom Management and Outcomes

    24 мая, 2025

    CONCLUSION: One third of community patients choose a telephone option over the web for reporting PROMs during cancer care. These patients are disproportionately from SDOH backgrounds at risk of poor clinical outcomes and have higher symptom management needs but ultimately experience similar clinical benefits as patients choosing the web. PROM programs should offer web alternatives… →

    Clinical Trials
  • Comparison of Antiseptics Containing Povidone-Iodine and Hypochlorous Acid Active Substances in Preventing Central Catheter-Related Bloodstream Infection in Intensive Care Units: A Randomized Controlled Trial

    24 мая, 2025

    CONCLUSION: In the study findings, central venous catheter-related bloodstream infection was observed to be less in catheter dressings applied with an antiseptic containing hypochlorous acid active substance than in catheter dressings applied with povidone-iodine. Hence, it is recommended to expand the use of an antiseptic containing hypochlorous acid active substance in catheter dressings. →

    Clinical Trials
  • The Effects of Pulmonary Rehabilitation Applied to Intensive Care Unit Patients on Dyspnea, Quality of Life, Depression, Anxiety, and Daily Living Activities: A Randomized Controlled Study

    24 мая, 2025

    CONCLUSION: It was found that PR applied both during the intensive care unit stay and at home by using the telerehabilitation method decreased anxiety, depression, and dyspnea in patients with COVID-19 and affected the quality of life and daily living activities positively. Continuing PR, which was applied to acute respiratory patients in the hospital and… →

    Clinical Trials
  • Safety and User Experience of a Generative Artificial Intelligence Digital Mental Health Intervention: Exploratory Randomized Controlled Trial

    23 мая, 2025

    CONCLUSIONS: This trial provides initial evidence that, with the right guardrails and process, generative AI can be successfully used in a digital mental health intervention (DMHI) while maintaining the user experience and relationship. It also provides an initial blueprint for approaches to technical and conversational guardrails that can be replicated to build a safe DMHI. →

    Clinical Trials
  • An App-Based WHO Mental Health Guide for Depression Detection: A Cluster Randomized Clinical Trial

    23 мая, 2025

    CONCLUSIONS AND RELEVANCE: This feasibility cluster randomized clinical trial demonstrated that the use, cost, and potential clinical benefit of the e-mhGAP-IG varied by setting, highlighting the importance of multisite feasibility studies when evaluating digital innovations intended for health care systems worldwide. →

    Clinical Trials
  • Efficacy of a 1% ibuprofen nanostructured topical gel in reducing in-office bleaching sensitivity following 35% hydrogen peroxide application: a randomized, controlled, triple-blind, split-mouth clinical trial

    23 мая, 2025

    CONCLUSION: The novel 1% ibuprofen nanostructured topical gel was ineffective in reducing BS and did not affect tooth color change. →

    Clinical Trials
  • Exploring Neurobiological Effects of Intermittent Theta-Burst Stimulation on the Left Cerebellum for Post-stroke Unilateral Neglect: A Preliminary Transcranial Magnetic Stimulation-Electroencephalography Investigation

    23 мая, 2025

    Unilateral neglect (UN) is a frequent consequence of stroke, for which effective therapeutic interventions are yet to be definitively established. This study aims to assess the therapeutic potential of intermittent theta-burst stimulation (iTBS) applied to the contralesional cerebellum in reducing UN symptoms. Additionally, it seeks to clarify the neurophysiological mechanisms involved, thereby supporting the development… →

    Clinical Trials
  • Clinical and radiographic evaluation of Er: YAG laser-assisted direct pulp capping in permanent teeth with carious exposure

    23 мая, 2025

    CONCLUSION: The inclusion of Er: YAG laser in DPC procedures enhances treatment outcomes, particularly when combined with Biodentine. This approach offers a promising alternative for vital pulp therapy in mature permanent teeth, ensuring better dentin bridge formation and clinical success. →

    Clinical Trials
  • Advancing dementia preparedness in Low and Middle Income countries: A randomized trial to improve diagnosis in primary care

    23 мая, 2025

    INTRODUCTION: Dementia disproportionately affects individuals in low- and middle-income countries (LMICs), yet diagnostic capabilities there are often inadequate. This study assesses the impact of a structured training program for primary care physicians (PCPs) in Cuba to improve early dementia detection. →

    Clinical Trials
  • The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota composition in individuals with stage III-IV periodontitis: a randomized controlled trial

    23 мая, 2025

    CONCLUSIONS: Combining L. reuteri with non-surgical periodontal therapy may not directly improve clinical indicators. The treatment showed potential benefits by changing the microbial composition of subgingival biofilm and enhancing treatment sensitivity. →

    Clinical Trials
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