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A phase I/IIa trial of atorvastatin in Japanese patients with acute Kawasaki disease and coronary artery aneurysms
CONCLUSIONS: We found that atorvastatin was safe and a dose up to 0.5 mg/kg/day for 6 weeks was well-tolerated in Japanese children with acute KD and CAAs. →
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Yandex Releases Yambda: The World’s Largest Event Dataset to Accelerate Recommender Systems
«`html Yandex Releases Yambda: The World’s Largest Event Dataset to Accelerate Recommender Systems Yandex has made a significant contribution to the recommender systems community by releasing Yambda, the world’s largest publicly available dataset for recommender system research and development. This dataset bridges the gap between academic research and industry-scale applications, offering nearly 5 billion anonymized user… →
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Stanford Researchers Introduced Biomni: A Biomedical AI Agent for Automation Across Diverse Tasks and Data Types
Stanford Researchers Introduced Biomni: A Biomedical AI Agent for Automation Across Diverse Tasks and Data Types Biomedical research is a rapidly evolving field aiming to advance human health through understanding disease mechanisms, identifying new therapeutic targets, and developing effective treatments. This area encompasses various disciplines, such as genetics, molecular biology, pharmacology, and clinical studies, which… →
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Neuroprotective Activity of Rasayana Formulation and Effect of Shigru Pallava Eye Drops on Intraocular Pressure as an Add-on Therapy Compared to the Standard of Care in Primary Open-Angle Glaucoma: Protocol for an Exploratory, Open-label, Two-arm Randomized Controlled Trial
CONCLUSIONS: If shown to be effective, the combined RF and SP eye drops could enhance neuroprotection and further control IOP in POAG, thereby addressing a significant need in current glaucoma therapy. This trial may provide a foundation for larger-scale investigations into integrative treatments for glaucoma management. →
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Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, controlled phase II clinical trial
CONCLUSIONS: Intrathecal BMMNC combined with an educational intervention improved disease severity and adaptability more than education alone in children with ASD. →
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The efficacy of combined lateral and anterior quadratus lumborum blocks in postoperative pain management following pelvic tumor resection: a randomized controlled trial
CONCLUSION: The ultrasound-guided QLB demonstrated superior analgesic efficacy and reduced morphine consumption compared to patients without the block. Our findings provide evidence supporting the hypothesis that QLB is an effective component of multimodal analgesia for individuals undergoing pelvic tumor resection and reconstructive surgery. →
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Effect of esketamine on postinduction hypotension in elderly patients undergoing elective noncardiac surgery: a secondary analysis of a randomized clinical trial
Postinduction hypotension (PIH) increases the risk of perioperative adverse events. This study aimed to test if low-dose esketamine could significantly decrease the incidence of PIH in elderly patients undergoing elective noncardiac surgery. This was a post hoc analysis of a randomized clinical trial in university-affiliated academic tertiary hospital. Patients (65 to 85 years, ASA physical… →
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Apple and Duke Researchers Present a Reinforcement Learning Approach That Enables LLMs to Provide Intermediate Answers, Enhancing Speed and Accuracy
Apple and Duke Researchers Present a Reinforcement Learning Approach That Enables LLMs to Provide Intermediate Answers, Enhancing Speed and Accuracy Long Chain of Thought (CoT) reasoning improves large language models’ (LLMs) performance on complex tasks but has notable drawbacks. The typical “think-then-answer” method slows down response times, disrupting real-time interactions, such as those in chatbots.… →
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People Follow Structure: How Less Hierarchy Changes the Workforce
Leo Acadia/theispot.com The Research The authors created a data set from publicly available information on LinkedIn in 2022 provided by Bright Data. It included all U.S. financial services industry companies on the platform, as well as their employees’ education and work histories over the past 20 years. Based on observations for 5,500 businesses that had… →
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The Powerful Lesson Pope Leo XIV Can Teach Leaders
History was made at the Vatican when the first American-born pope—Cardinal Robert Prevost, now Pope Leo XIV—was elected as the new head of the Roman Catholic Church. As a devout Catholic, I welcome the election of the 69-year-old cleric as a sign of strength and health for the church and its 1.4 billion communicants around… →