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Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
CONCLUSION: Esketamine may decrease the dosage of norepinephrine in patients with septic shock receiving invasive mechanical ventilation. It is beneficial for stabilizing hemodynamics and appears to be an effective and safe agent for patients with septic shock requiring invasive mechanical ventilation. →
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Interpretable noninvasive diagnosis of tuberculous pleural effusion using LGBM and SHAP: development and clinical application of a machine learning model
CONCLUSIONS: This interpretable LGBM-based model provides a reliable, noninvasive tool for TPE diagnosis. It supports clinical decision-making with real-time risk assessment and promises broader applicability through future integration into clinical information systems. →
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Can LLMs Really Judge with Reasoning? Microsoft and Tsinghua Researchers Introduce Reward Reasoning Models to Dynamically Scale Test-Time Compute for Better Alignment
Can LLMs Really Judge with Reasoning? Introduction Recent advancements in large language models (LLMs) have brought attention to their capabilities in reasoning and judgment. Researchers from Microsoft and Tsinghua University have introduced Reward Reasoning Models (RRMs), which aim to enhance the alignment of LLMs through dynamic scaling of computational resources during test-time evaluations. The Role… →
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Dextrose prolotherapyeffectin improving thetemporomandibular joint disc displacement symptoms without reduction refractory to conservative treatment: a pilot study
This study aimed to evaluate the efficacy of intra-articular injection of 5% Dextrose (D5W) prolotherapy in treatment symptoms of Temporomandibular Joint (TMJ) Disc Displacement without Reduction (DDwoR) with limited mouth opening (Closed-Lock) of patients’refractory to pharmacological and physical therapy. This pilot study included twenty female patients suffering from symptoms of DDwoR with limited mouth opening… →
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Efficacy and safety of combining tislelizumab with capecitabine compared to capecitabine alone in the adjuvant treatment of biliary tract cancers: rationale and protocol design for a randomized clinical trial
BACKGROUND: Adjuvant therapy with capecitabine is recommended to improve survival for resectable biliary tract cancers (BTC) patients. Considering that the combination of PD-1/PD-L1 inhibitors with chemotherapy has demonstrated a survival benefit over chemotherapy alone in advanced stage BTC, we aim to evaluate the treatment efficacy and safety of tislelizumab, a PD-1 inhibitor, combined with capecitabine… →
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My patient might be depressed — can I still screen for MCI? Exploring cognitive performance on the MoCA in older people screened for depressive symptoms with the PHQ-9
CONCLUSION: Cognitive screening with the MoCA seems to be robust against depression and could therefore be used to screen for MCI regardless of depression level. →
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Effects of a novel differential diagnosis aid for managing patients with unexplained fatigue in primary care: a prospective randomized, controlled, open and multicenter study in primary care
CONCLUSIONS: In this pilot study, the FDDA, a structured diagnostic aid for guiding PCPs in identifying the causes of unexplained fatigue in their patients, was not able to show a global improvement in patient outcomes despite improvements in fatigue and satisfaction with care. The evaluation of fatigue in larger-scale studies is warranted. →
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Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial
Pediatric major depressive disorder (MDD) represents a leading cause of disability worldwide in children and adolescents, while its underlying pathophysiology remains largely elusive. The endocannabinoid system (ECS) and the hypothalamus-pituitary-adrenal (HPA) axis are considered intertwined regulatory systems crucially implicated in the pathophysiology of depressive disorders. This study explores the cross-sectional and longitudinal association between the… →
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Tislelizumab as adjuvant therapy following endoscopic surgery for resectable recurrent nasopharyngeal carcinoma: a randomized clinical trial
CONCLUSIONS: Tislelizumab as adjuvant therapy significantly enhanced PFS and PFI, with a favorable safety profile. Longer follow-up is necessary to determine whether this regimen can be considered as the standard of care for patients with resectable rNPC following endoscopic surgery. →
