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Neuroprotective Activity of Rasayana Formulation and Effect of Shigru Pallava Eye Drops on Intraocular Pressure as an Add-on Therapy Compared to the Standard of Care in Primary Open-Angle Glaucoma: Protocol for an Exploratory, Open-label, Two-arm Randomized Controlled Trial
CONCLUSIONS: If shown to be effective, the combined RF and SP eye drops could enhance neuroprotection and further control IOP in POAG, thereby addressing a significant need in current glaucoma therapy. This trial may provide a foundation for larger-scale investigations into integrative treatments for glaucoma management. →
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Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, controlled phase II clinical trial
CONCLUSIONS: Intrathecal BMMNC combined with an educational intervention improved disease severity and adaptability more than education alone in children with ASD. →
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The efficacy of combined lateral and anterior quadratus lumborum blocks in postoperative pain management following pelvic tumor resection: a randomized controlled trial
CONCLUSION: The ultrasound-guided QLB demonstrated superior analgesic efficacy and reduced morphine consumption compared to patients without the block. Our findings provide evidence supporting the hypothesis that QLB is an effective component of multimodal analgesia for individuals undergoing pelvic tumor resection and reconstructive surgery. →
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Effect of esketamine on postinduction hypotension in elderly patients undergoing elective noncardiac surgery: a secondary analysis of a randomized clinical trial
Postinduction hypotension (PIH) increases the risk of perioperative adverse events. This study aimed to test if low-dose esketamine could significantly decrease the incidence of PIH in elderly patients undergoing elective noncardiac surgery. This was a post hoc analysis of a randomized clinical trial in university-affiliated academic tertiary hospital. Patients (65 to 85 years, ASA physical… →
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Apple and Duke Researchers Present a Reinforcement Learning Approach That Enables LLMs to Provide Intermediate Answers, Enhancing Speed and Accuracy
Apple and Duke Researchers Present a Reinforcement Learning Approach That Enables LLMs to Provide Intermediate Answers, Enhancing Speed and Accuracy Long Chain of Thought (CoT) reasoning improves large language models’ (LLMs) performance on complex tasks but has notable drawbacks. The typical “think-then-answer” method slows down response times, disrupting real-time interactions, such as those in chatbots.… →
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People Follow Structure: How Less Hierarchy Changes the Workforce
Leo Acadia/theispot.com The Research The authors created a data set from publicly available information on LinkedIn in 2022 provided by Bright Data. It included all U.S. financial services industry companies on the platform, as well as their employees’ education and work histories over the past 20 years. Based on observations for 5,500 businesses that had… →
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The Powerful Lesson Pope Leo XIV Can Teach Leaders
History was made at the Vatican when the first American-born pope—Cardinal Robert Prevost, now Pope Leo XIV—was elected as the new head of the Roman Catholic Church. As a devout Catholic, I welcome the election of the 69-year-old cleric as a sign of strength and health for the church and its 1.4 billion communicants around… →
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DeepSeek Releases R1-0528: An Open-Source Reasoning AI Model Delivering Enhanced Math and Code Performance with Single-GPU Efficiency
DeepSeek Releases R1-0528: An Open-Source Reasoning AI Model Delivering Enhanced Math and Code Performance with Single-GPU Efficiency Technical Enhancements DeepSeek, a prominent AI company from China, has launched an updated version of its reasoning model, named DeepSeek-R1-0528. This release significantly enhances the model’s capabilities in mathematics, programming, and logical reasoning, positioning it as a strong… →
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The effect of traditional Thai massage vs routine physical therapy on gait pattern in spastic cerebral palsy: A cross-over randomized controlled trial
CONCLUSIONS: TM has a positive effect on gait performance, as indicated by GPS and increased activity in the right rectus femoris muscle when compared to PT. A large-scale non-inferiority trial is required to affirm the impact of TM. →
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Changes in Daily Functioning in Association With Tau and Amyloid Among Unimpaired Older Adults With and Without Elevated Amyloid
BACKGROUND AND OBJECTIVES: Everyday functioning declines gradually over time in Alzheimer disease (AD), with the earliest changes potentially occurring at the preclinical stage. We investigated how changes in everyday functioning relate to (changes in) amyloid and tau in a large sample of cognitively unimpaired older adults, most of whom had elevated amyloid levels at the… →
