CONCLUSIONS: In patients with PsA receiving tofacitinib, five distinct trajectory groups were identified with different baseline characteristics and treatment outcomes, but no clear trends in AEs. The tofacitinib 5 and 10 mg twice daily models showed comparable trajectories and baseline characteristics. In patients with HDA, enthesitis and tender joint count may impact timing and/or magnitude… →

At a time of increased uncertainty throughout our business, I feel that it’s important to be a rock, and to show positivity, for the people on my team. But I know it’s important to show more vulnerability at times like this. How can I do both? It’s easy to equate vulnerability with sharing your own… →
The GTM Podcast is available on any major directory, including: Apple Podcasts Spotify YouTube Rick Kelley is the former VP of Meta’s Global Business Group, where he led a $10B+ revenue organization and played a pivotal role in building out Meta’s go-to-market teams across North America and EMEA. Over his 15-year career at Meta, Rick… →
CONCLUSION: Sake lees intake may reduce fecal uremic toxins, elevate plasma D-alanine levels, alleviate constipation, and modify the gut microbiome. However, future studies are needed to confirm these effects in patients with CKD. →

CONCLUSIONS: The 10-week Healthy Action Process Approach-based WeChat mini program intervention effectively improved MVPA, FVC, integrated lifestyle indicator, psychosocial resources of behavior change, and health-related outcomes among Chinese patients with CVDs. This intervention provides a valuable addition to rehabilitation strategies aimed at promoting long-term health and activity in cardiac patients following hospital discharge. →

OpenAI Introduces Four Key Updates to Its AI Agent Framework OpenAI has announced targeted updates to its AI agent development stack, aimed at expanding platform compatibility, improving support for voice interfaces, and enhancing observability. These updates are part of OpenAI’s progression toward building practical, controllable, and auditable AI agents for real-world applications across client and… →
Hugging Face Releases SmolVLA: A Compact Vision-Language-Action Model for Affordable and Efficient Robotics Introduction Recent advancements in robotic control using large-scale vision-language-action (VLA) models have been hampered by high hardware and data requirements. Traditional VLA models often rely on transformer-based architectures with billions of parameters, leading to substantial memory and computational costs. This restricts experimentation… →
From Exploration Collapse to Predictable Limits: Shanghai AI Lab Proposes Entropy-Based Scaling Laws for Reinforcement Learning in LLMs Recent advances in reasoning-centric large language models (LLMs) have expanded the scope of reinforcement learning (RL), enabling broader generalization and reasoning capabilities. However, this shift introduces significant challenges, particularly in scaling the training compute required for learning… →
Snowflake Charts New AI Territory: Cortex AISQL & Snowflake Intelligence Poised to Reshape Data Analytics Introduction The data cloud landscape is evolving as Snowflake, a leader in data warehousing and analytics, introduces two new AI solutions: Cortex AISQL and Snowflake Intelligence. Announced at the Snowflake Summit, these tools aim to change how organizations interact with… →
Clinical trials of anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer disease (AD) infer target engagement from Aβ positron emission tomography (PET) and/or fluid biomarkers such as cerebrospinal fluid (CSF) Aβ42/40. However, these biomarkers measure brain Aβ deposits indirectly and/or incompletely. In contrast, neuropathologic assessments allow direct investigation of treatment effects on brain Aβ deposits-and on potentially… →
