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ReasonFlux-PRM: A Trajectory-Aware Reward Model Enhancing Chain-of-Thought Reasoning in LLMs
«`html Understanding the Role of Chain-of-Thought in LLMs Large language models (LLMs) are increasingly utilized to tackle complex tasks such as mathematics and scientific reasoning through structured chain-of-thought approaches. These models do not simply provide answers; they reason through intermediate steps that simulate logical thought processes. This technique enhances reasoning accuracy and facilitates clearer error… →
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Effect of the Otago Exercise Program on Activities of Daily Living in Older Adults With Sarcopenia
CONCLUSION: OEP significantly enhances activities of daily living, improves muscle strength, balance, and physical function in older adults, and is more effective than conventional rehabilitation exercise programs, making it suitable for extensive clinical application. →
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Psychoeducation for Caregivers of Individuals With Borderline Personality Disorder: A Randomized Controlled Trial of Multiple Family Group Therapy
Multiple family group (MFG) therapy is a psychoeducational intervention designed for caregivers of individuals with borderline personality disorder (BPD). This study is the first to compare MFG therapy with treatment as usual (TAU). The objectives were to assess MFG therapy’s impact on caregivers’ social functioning, perceived support from mental health professionals, coping and communication skills… →
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Effectiveness of the WeChat-based mini-program («Sober Time ACT») on individuals with hazardous drinking in China: a randomized controlled trial
CONCLUSIONS: These findings provide preliminary prospective evidence that, despite the limitation of high dropout rate, the «Sober Time ACT» mini-program not only effectively reduces alcohol craving and consumption but also improves related psychological indicators to a certain extent, providing an innovative and effective intervention tool for addressing hazardous drinking in China. →
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The study on delirium side-effects after ultra-brief pulse electroconvulsive therapy
CONCLUSION: Compared with BP ECT, UBP ECT may reduce the incidence of delirium post-treatment in SCZ without a significant difference in efficacy. The higher cholinesterase levels in the UBP group suggest that UBP ECT may reduce neuronal asynchronous depolarization, cholinergic disorder, and pro-inflammatory responses, thereby reducing the impact on delirium. These findings provide partial scientific… →
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Homologous recombination deficiency (HRD) tests for ovarian cancer: a multicenter French phase II study (HERO)
BACKGROUND: The identification of homologous recombination deficient (HRD) tumor is now a crucial step for the therapeutic management of ovarian cancer. The HRD tumors are both sensitive to olaparib maintenance treatment and to platinum-based chemotherapy. Despite the large amount of HRD tests currently available, only a few HRD tests were prospectively validated on a clinical… →
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Evaluating the efficacy of rumination-focused cognitive-behavioral therapy in alleviating depression, negative affect, and rumination among patients with recurrent major depressive disorder: a randomized, multicenter clinical trial
CONCLUSIONS: Group-based Rumination-Focused Cognitive-Behavioral Therapy (g-RFCBT) demonstrated significant efficacy in reducing the severity of depressive symptoms, rumination, and negative affect among individuals with major depressive disorder (MDD). Moreover, these therapeutic benefits were maintained over a 6-month follow-up period, suggesting durable treatment effects. →
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Impact of the 5A nursing model on immune balance and lymph node metastasis in primary liver cancer patients post-CyberKnife treatment
CONCLUSION: The 5A nursing model significantly impacts immune balance and reduces lymph node metastasis in primary liver cancer patients following CyberKnife treatment. This model enhances CD8 + T cell and NK cell concentrations while reducing Tregs cells, thereby promoting a stronger anti-tumor immune response and ultimately decreasing the rate of lymph node metastasis. →
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A prospective cluster randomized trial of an interventions bundle to reduce inappropriate antibiotic use for upper respiratory tract infections in the outpatient setting
CONCLUSION: A multi-component intervention can significantly reduce inappropriate antibiotic prescriptions for URTIs in the outpatient setting. →
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Effects of a flavonoid-enriched orange juice on antioxidant capacity, lipid profile, and inflammation in obese patients: A randomized placebo-controlled trial
Recent studies underscore the therapeutic potential of citrus polymethoxylated flavonoids-such as tangeretin, sinensetin, and nobiletin-in attenuating inflammation, mitigating oxidative stress, and enhancing metabolic health in individuals with obesity. This randomized, double-blind, placebo-controlled clinical trial assessed the effects of a functional orange juice enriched with flavonoids (200 mL/day) combined with a low-calorie diet over six weeks… →
