-
Turn Customer Complaints Into Innovation Blueprints
Carolyn Geason-Beissel/MIT SMR | Getty Images Most organizations treat customer complaints as a source of frustration to be contained, apologized for, and moved off the books as swiftly as possible. But what if those complaints are actually a practical source of innovation? In other words, what about treating complaints as an early-warning system and a… →
-
Surgical decision-making strategies in preterm neonates with necrotizing enterocolitis: A randomized controlled clinical trial
CONCLUSIONS: The strategy based on MD7 and paracentesis was superior to Bell’s criteria for guiding surgical decisions in preterm neonates with NEC, reducing mortality. The main limitation was a small number of non-therapeutic laparotomies, expected due to the greater sensitivity of the strategy. →
-
A Thorough QT Study to Assess the Effects of Milvexian on Cardiac Repolarization in Healthy Participants
Milvexian is an oral factor XIa inhibitor in development for prevention of major thromboembolic conditions. This randomized, double-blind, placebo- and positive-controlled, multiple-dose, four-period crossover study assessed the cardic safety of milvexian (including effects on the QT interval of the electrocardiogram), with a supporting in vitro component. Sixty-six participants were enrolled. In each treatment period, participants… →
-
Evaluation of a New Formulation That Improves the Bioavailability and Food Effect of Abiraterone: An Open-Label, Crossover, Randomized, Controlled, Phase I Clinical Trial
This first-in-human phase I trial evaluated RL001, a self-emulsifying soft-capsule abiraterone developed to overcome the low bioavailability and food sensitivity associated with the 1000-mg Zytiga tablet that is used with prednisone according to NCCN guidelines. Plasma concentrations were quantified by LC-MS/MS and modeled in Phoenix WinNonlin 8.1 and SAS; GeoMean confidence intervals compared pharmacokinetics. Against… →
-
Claude Code for Everyone
Claude Code for everyone On January 12th, Anthropic announced Claude Cowork. The internet went wild. For months, developers have been running laps with Claude Code. Everyone else – marketers, operators, sales leaders, founders – watched from the outside. They could see the power, but they couldn’t get to it without crossing the barrier of the… →
-
Inflammation and insulin profiles in men assigned to exercise vs. usual care for prostate cancer: results from the active surveillance exercise (ASX) randomized controlled trial
CONCLUSIONS: We observed no changes in markers of insulinemia, inflammation, or PSA from a 16-week at-home walking intervention vs. control in individuals with low-risk PCa. →
-
Analysis of risk factors for recurrence in children with asthmatic bronchopneumonia during remission and discussion on the therapeutic effect of diprophylline combined with budesonide
CONCLUSION: DPL combined with BUD can quickly relieve the clinical symptoms and reduce the level of inflammation in children with ABP, with good safety. More attention should be paid to breastfeeding support, environmental tobacco control and nutritional intervention to reduce the risk of relapse during remission. →
-
Effectiveness of Closed Blood-Sampling Devices in Critically Ill Adults: A Feasibility Trial
CONCLUSIONS: A full-scale RCT evaluating CBSDs in ICU patients is feasible with protocol modifications, including broader site participation and improved device integration with advanced monitoring systems. Preliminary data suggest that CBSDs may reduce transfusion requirements and blood loss in critically ill patients. →
-
A phase III, randomised, double-blind, multi-dose, placebo- and naproxen-controlled study to evaluate the efficacy and safety of fasinumab in patients with pain due to osteoarthritis of the knee or hip
CONCLUSION: In a difficult-to-treat population with OA, fasinumab 1 mg Q4W achieved clinically meaningful improvements by week 16 versus placebo and naproxen. The safety profile was similar to that previously observed for fasinumab. →
-
An Internet-Delivered Intervention to Reduce LGBTQ+ Prejudice Among Romanian Teachers: Randomized Controlled Trial
CONCLUSIONS: The intervention offers initial evidence for the effectiveness of a cost-effective and portable online resource for educators and high school counselors, particularly in regions where negative attitudes toward the LGBTQ+ community are prominent. The results show that integrating blended cognitive (information), affective (indirect contact and perspective taking), and behavioral (self-efficacy and empowerment) approaches is… →