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  • Multi-institutional, randomized, controlled trial to assess the efficacy and tolerability of a reusable, self-contained cryotherapy delivery device

    31 июля, 2025

    CONCLUSIONS: CMP use for 14 days following chemotherapy infusion mitigated chemotherapy-associated OP and AU. The effect was seen over two cycles of treatment with known stomatotoxic agents having both short and long half-lives. The device was well tolerated. →

    Clinical Trials
  • Efficacy and safety of commercially available cosmetic perioperative skincare products for non-invasive energy-based device treatment: a single-centre, randomized, placebo-controlled trial

    31 июля, 2025

    Photoelectric therapies (or non-invasive energy-based device treatment), especially picosecond lasers and intense pulsed light (IPL) treatments, are widely used to manage various cutaneous conditions, including pigmentation, inflammation, and signs of aging. However, these treatments can also impair the integrity of the skin barrier, making post-treatment repair of skin barrier function essential to maintain perioperative curative… →

    Clinical Trials
  • Prognostic factors associated with primary non-responsiveness to antibiotics and appendicitis recurrence for CT-diagnosed uncomplicated acute appendicitis: secondary analysis of two randomized clinical trials

    31 июля, 2025

    CONCLUSION: Patients with an appendiceal diameter ≥15 mm and a body temperature >38°C may not be optimal candidates for non-operative treatment for uncomplicated acute appendicitis. Patients with CRP <100 mg/l at 24 h of antibiotic treatment for uncomplicated acute appendicitis have a 99% likelihood of successful antibiotic therapy. →

    Clinical Trials
  • Levels of several inflammatory cytokines in acne patients before and after isotretinoin therapy: a randomized, controlled clinical trial

    31 июля, 2025

    CONCLUSION: The anti-inflammatory effects of isotretinoin in acne patients result from its ability to decrease serum levels of inflammatory cytokines (IL-8, IL-36, TNF-α, TSLP, and TWEAK). →

    Clinical Trials
  • Efficacy and safety of dapagliflozin in patients hospitalized with COVID-19 with and without type 2 diabetes: a prespecified analysis of the DARE-19 randomized trial

    31 июля, 2025

    CONCLUSIONS: Initiating dapagliflozin in patients hospitalized for acute COVID-19 was well tolerated and safe, irrespective of T2D status. Serum biomarker levels remained stable and comparable between treatment groups, indicating no increased risk of adverse metabolic or renal effects with dapagliflozin in this clinical scenario. →

    Clinical Trials
  • Extracellular vesicles from bronchoalveolar lavage fluid provide insights into the inhaled corticosteroids treatment response in COPD

    31 июля, 2025

    CONCLUSIONS: Our findings highlight the potential of BALF-derived EVs as a biomarker source for predicting ICS responsiveness in COPD. The CST family, especially CST1, potentially serves as a valuable indicator for identifying patients who are more likely to benefit from ICS treatment. →

    Clinical Trials
  • Efficacy of superior laryngeal nerve block in reducing retching during transesophageal echocardiography: a randomized controlled trial

    31 июля, 2025

    CONCLUSIONS: Bilateral iSLN block significantly reduces the incidence of retching and oropharyngeal mucosal bleeding, while improving patient comfort, increasing the rapid TEE probe insertion rate, and stabilizing MAP during TEE examination. This technique can significantly improve patient experience and safety during TEE procedures. →

    Clinical Trials
  • Effect of nasal mask oxygenation on incidence of hypoxemia during gastroscopy with propofol sedation in patients at risk of hypoxemia: a prospective randomized controlled study

    31 июля, 2025

    CONCLUSION: In patients with obesity or OSA, nasal mask oxygenation during gastroscopy with propofol sedation significantly reduced the incidences of hypoxemia, subclinical respiratory depression, and severe hypoxemia without increasing other adverse events. →

    Clinical Trials
  • Dexamethasone for 12 weeks for reducing fatigue in patients receiving palliative chemotherapy: A Phase 3, Placebo-Controlled, Randomized Controlled Trial

    31 июля, 2025

    CONCLUSION: Dexamethasone did not significantly reduce cancer-associated fatigue or improve QOL in patients receiving palliative chemotherapy. The findings highlight the need to explore alternative, more effective interventions for managing fatigue in this population. →

    Clinical Trials
  • How I use BANT to qualify prospects [+ expert tips]

    31 июля, 2025

    I recall the first time I was introduced to the BANT framework. I was enrolled in an online education program designed to train me as a sales development representative. The program was self-paced, allowing us to study the material at our convenience. I made flashcards to assist my memorization, and I came across the word… →

    AI Sales
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