CONCLUSIONS AND RELEVANCE: In this ancillary study of the CLEAR trial, the GO-FAR score and CFS effectively estimated long-term all-cause mortality, particularly when combined with the CCI. These tools may help clinical decision-making, resource allocation, and advanced care planning in aging, multimorbid patient populations. →

CONCLUSIONS AND RELEVANCE: In this cohort study of patients with AIS treated with intravenous thrombolysis, brain frailty markers-particularly white matter changes, cortical atrophy, and total brain frailty-were associated with worse outcomes. Consideration of these neuroimaging markers may better inform clinicians and patients about treatment expectations from thrombolytic therapy. →

Background A 5-year screening interval for CT colonography (CTC) and a 2-year screening interval for fecal immunochemical tests (FITs) have been recommended on the basis of the natural history of colorectal cancer (CRC). Purpose To assess whether the recommended 5-year interval for screening CTC is appropriate and whether CTC is associated with earlier diagnosis relative… →

CONCLUSION: Both Jarlsberg cheese, characterized by its unique Propionibacterium freudenreichii content, and Norvegia cheese, when combined with off-season training, led to increases in LBM, VO₂ max, and MS, with no significant differences observed between groups. However, there was a trend toward greater improvements in MS in the Jarlsberg group. Overall, increases in LBM through structured… →

CONCLUSION: Approximately one-fifth of the patients with refractory IBS/FD fulfill the NCWS criteria. Therefore, screening for NCWS in patients with refractory IBS or FD is extremely important to limit unnecessary pharmacotherapy and enhance patient outcomes. →

CONCLUSION: The combination of percutaneous acupoint electrical stimulation in gastroscopy patients has been demonstrated to be both highly safe and effective. The benefits of this approach include the promotion of postoperative gastrointestinal function, the reduction of stress response, the attainment of optimal results, and the enhancement of patient satisfaction. →

CONCLUSIONS: Despite the low pCR rate, all patients were able to undergo curative surgery, and long-term outcomes were encouraging with 5-year EFS 85.6%. Decreases in tumor vascularization with treatment were detected by DCE-MRI parameters irrespective of initial chemotherapy received. Adipogenesis/fatty acid metabolism and cells associated with immunosuppression are potential mechanisms of resistance and targets for… →

CONCLUSION: Topical ozonated olive oil significantly enhances wound healing, quality of life, glycemic control, and reduces inflammation in DFU patients. Its affordability and efficacy make it a promising adjunctive therapy. Further studies should explore long-term effects and mechanisms. It offers a scalable solution for DFU management. →

CONCLUSION: Combined vitamin D and E supplementation significantly reduces pain and PMS in vitamin D-deficient women. Healthcare providers may consider this regimen for dysmenorrhea management, pending further optimization studies. →