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A Phase II Pilot Study of Anti-PD-L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple-Negative Breast Cancer With or Without Germline BRCA Mutation
CONCLUSION: Our study demonstrated modest clinical benefits of D + O with ORR of 28.6% in subsets of heavily pretreated TNBC. Further detailed classification of DCs to understand the predictive role of DCs and prospective validation in a large cohort is required. →
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Virtual Standardized Patients for Improving Clinical Thinking Ability Training in Residents: Randomized Controlled Trial
CONCLUSIONS: VSPs reinforce the foundational knowledge of internal medicine among medical students and enhance their clinical thinking abilities, as well as improve their capacity for independent work. The VSP system is feasible, practical, and cost-effective, making it worthy of further promotion in clinical education. →
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Leading an Industrial Giant Through Volatility
Photo courtesy of Orbia Sameer Bharadwaj is CEO of Orbia, a global sustainable solutions company. After earning a doctorate in chemical engineering from the University of Minnesota, Bharadwaj worked at Dow Chemical, Boston Consulting Group, and Cabot Corp. He joined Orbia, then known as Mexichem, in 2016 and became CEO in 2021, leading its transformation… →
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The Greenhushing Trap
golubovy/Getty Images Should companies still talk about their sustainability efforts — and, if so, how much? According to a July 2025 report, 39% of U.S. companies surveyed had reduced or stopped publicly promoting their sustainability investments even while maintaining or increasing them relative to 2024. This retreat into silence — greenhushing — can undermine a… →
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Three Things to Know About Implementing Workplace AI Tools
Pla2na/Getty Images AI tools are proliferating as organizations continue to invest in their deployment, but how effective are they at increasing employee performance? Three recent research articles suggest that although AI can surely be useful in the workplace, its limitations are significant and its consequences for human dynamics unclear. Before implementing AI tools, managers should… →
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AI-Savvy Boards Drive Superior Performance
Igor Kutyaev/Getty Images Back in 2019, we found that only 24% of large U.S. companies had “digitally savvy” boards — those with three or more directors experienced in digital technologies. These companies outperformed their peers, with over 30% better performance across metrics like market cap growth. By 2024, a striking shift had occurred: When we… →
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Science, Innovation, and Economic Growth: OpenAI’s Ronnie Chatterji
In this episode of Me, Myself, and AI, OpenAI’s chief economist Ronnie Chatterji describes how artificial intelligence is reshaping both the economy and scientific innovation. Ronnie discusses the dual economic impacts of AI — the near-term boost from infrastructure investments like chips and data centers, and the longer-term productivity gains as AI tools integrate into… →
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Podcast: Focus on Your Story, Not Your Résumé
Suzanne Muchin rues the day people started referring to their careers as “paths.” “You always talk about a career path, your career journey, your career trajectory. They’re all a vocabulary that suggests you’re supposed to get onto a road and then ride it,” said Muchin, a clinical professor of management and organizations at Kellogg. But… →
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Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With Alzheimer Disease: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, home-based gamma tACS was feasible and improved clinical outcomes in AD, with neurophysiological evidence of brain engagement. These findings support further investigation of gamma tACS as a potential therapeutic intervention for AD. →
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Compression Hosiery to Avoid the Post-Thrombotic Syndrome: a synopsis of the CHAPS RCT
CONCLUSIONS: The sample size was not reached, which precluded any formal statistical analysis. Although a difference in the incidence of post-thrombotic syndrome was demonstrated, the effect size could not be determined. There is interest in understanding optimal strategies for the prevention of post-thrombotic syndrome in these patients and a re-run of this trial should occur. →
