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Fusion oncoproteins, formed by chromosomal translocations, are key drivers in many cancers, especially pediatric ones. These chimeric proteins are difficult to target with drugs due to their large, disordered structures and lack of distinct binding pockets. Traditional drug design methods, like small molecules, often fail because they need more specificity or bind crucial cellular proteins.…
Microsoft’s AI courses offer comprehensive coverage of AI and machine learning concepts for all skill levels, providing hands-on experience with tools like Azure Machine Learning and Dynamics 365 Commerce. They emphasize practical applications, advanced techniques, and responsible AI practices, equipping learners to develop and deploy AI solutions ethically and effectively. This article lists the top…
Audio classification has evolved significantly with the adoption of deep learning models. Initially dominated by Convolutional Neural Networks (CNNs), this field has shifted towards transformer-based architectures, which offer improved performance and the ability to handle various tasks through a unified approach. Transformers surpass CNNs in performance, creating a paradigm shift in deep learning, especially for…
The ability to discern relevant and essential information from noise is paramount in AI, particularly within large language models (LLMs). With the surge of information and the complexity of tasks, there’s a need for efficient mechanisms to enhance the performance and reliability of these models. Let’s explore the essential tools & techniques for refining LLMs…
Monte Carlo (MC) methods rely on repeated random sampling, so they are widely utilized for simulating and approximating complicated real-world systems. These techniques work especially well for financial mathematics, numerical integration, and optimization issues, particularly those about risk and derivative pricing. However, for complex issues in Monte Carlo, an unfeasibly large number of samples are…
Chain-of-Thought (CoT) reasoning enhances the capabilities of LLMs, allowing them to perform more complex reasoning tasks. Despite being primarily trained for next-token prediction, LLMs can generate detailed steps in their responses when prompted to explain their thought process. This ability, which resembles logical reasoning, is paradoxical since LLMs are not explicitly designed for reasoning. Studies…
Zyphra announced the release of Zyda, a groundbreaking 1.3 trillion-token open dataset for language modeling. This innovative dataset is set to redefine the standards of language model training and research, offering an unparalleled combination of size, quality, and accessibility. Zyda amalgamates several high-quality open datasets, refining them through rigorous filtering and deduplication. The result is…
Large language models (LLMs) have revolutionized code generation, but their autoregressive nature poses a significant challenge. These models generate code token by token, without access to the program’s runtime output from the previously generated tokens. This lack of a feedback loop, where the model can observe the program’s output and adjust accordingly, makes it difficult…
Language models (LMs) are designed to reflect a broad range of voices, leading to outputs that don’t perfectly match any single perspective. To avoid generic responses, one can use LLMs through supervised fine-tuning (SFT) or reinforcement learning with human feedback (RLHF). However, these methods need huge datasets, making them impractical for new and specific tasks.…
The Qwen Team recently unveiled their latest breakthrough, the Qwen2-72B. This state-of-the-art language model showcases advancements in size, performance, and versatility. Let’s look into the key features, performance metrics, and potential impact of Qwen2-72B on various AI applications. Qwen2-72B is part of the Qwen2 series, which includes a range of large language models (LLMs) with…