Clinical Trials
Category Added in a WPeMatico Campaign
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Cost-Utility Analysis and Value-Based Pricing of Digital Therapeutics for Pulmonary Rehabilitation in Chronic Respiratory Disease: Economic Evaluation Based on a Randomized Controlled Trial
CONCLUSIONS: DTx for pulmonary rehabilitation demonstrated the cost-effectiveness compared with standard treatment. These findings support its potential for improving outcomes in patients with chronic respiratory disease and provide a pricing framework to facilitate its integration into health care systems.
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Hormonal mechanisms of women’s risk in the face of traumatic stress
Women are underrepresented in biomedical research, limiting understanding of their disproportionate rates of stress-related disorders. Although men experience more trauma, women are twice as likely to develop posttraumatic stress disorder (PTSD). We tested whether ovarian hormones contribute to this disparity via their influence on threat-related brain activity. In a randomized, double-blind crossover study of 110…
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Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, DCBT provided significant and sustained benefits to adults with GAD. Given the limitations in access to empirically supported CBT, an efficacious DCBT program has clear potential for public health benefit.
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Effectiveness and cost-effectiveness of a multimodal, physiotherapist-led, vocational intervention for people with rheumatoid arthritis or axial spondyloarthritis and a reduced work ability: a randomized, controlled trial
To evaluate the (cost-)effectiveness of a physiotherapist-led, multimodal vocational intervention compared to usual care in adults with rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA) experiencing reduced work ability. (Self-)employed people with RA or axSpA and reduced work ability were randomized to a 12-month vocational intervention or usual care. Assessments were conducted at baseline, 3, 6,…
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Comparison of unilateral biportal and percutaneous endoscopic discectomy in treating far lateral lumbar disc herniation
CONCLUSION: Our study results suggest that UBE is a viable alternative to PELD for treating FLLDH, offering comparable clinical outcomes with reduced radiation exposure.
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Effect of self-acupressure on fatigue and sleep quality in patients with multiple sclerosis: A randomized controlled trial
CONCLUSION: Self-acupressure was proven to reduce fatigue levels and improve sleep quality in adults with multiple sclerosis. In conclusion, self-acupressure is an accessible, cost-effective, and efficacious technique for alleviating fatigue and enhancing sleep quality in patients with multiple sclerosis.
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Azathioprine for the treatment of early Parkinson’s disease (AZA-PD): a randomised, double-blind, placebo-controlled, proof-of-concept, phase 2 trial
BACKGROUND: The immune system is implicated in Parkinson’s disease aetiology and prognosis. Although there are effective symptomatic treatments for Parkinson’s disease, there are currently no therapies that slow down disease progression. We aimed to investigate the clinical efficacy of the broadly acting peripheral immunosuppressant drug azathioprine for patients with early Parkinson’s disease.
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Getting to Implementation: applying data-driven implementation strategies to improve guideline concordant surveillance for hepatocellular carcinoma
CONCLUSIONS: GTI sustainably improved HCC surveillance, suggesting that applying data-driven implementation strategies within a manualized facilitation approach can improve care.
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Enhanced patient counselling and SMS reminder messages to improve access to community-based eye care services in Meru, Kenya: an embedded, pragmatic, individual-level, randomised, controlled, adaptive platform trial
BACKGROUND: In Meru county, Kenya, only 46% of people identified with an eye problem during screening go on to access eye care services at local clinics, with younger adults (aged 18-44 years) being the least likely to receive eye care. This study aimed to test whether provision of additional information was associated with better access…
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Monotherapy vs. combination paracetamol and tramadol for cancer-related pain in the emergency department: a comparative study
CONCLUSION: The co-administration of paracetamol and tramadol intravenously resulted in superior and sustained analgesia when compared with monotherapy, without an increase in adverse effects. These findings provide support for the utilization of this combination as a safe and effective multimodal strategy in the acute management of cancer-related pain in the emergency department.