Clinical Trials
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Short-term effects and influencing factors of short-term personalized vestibular rehabilitation on acute peripheral vestibular syndrome
Objective: To investigate the short-term effects and influencing factors of short-term personalized vestibular rehabilitation (ST-PVR) on acute peripheral vestibular syndrome (APVS). Methods: A randomized controlled study was conducted. APVS patients who visited the Department of Otolaryngology of Henan Provincial People’s Hospital from April 2024 to February 2025 were enrolled and divided into vestibular rehabilitation group…
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Cognitive Reappraisal as a Potential Mechanism of Unified Protocol for Emotional Disorders
This study aimed to investigate changes in cognitive reappraisal as a mechanism of the unified protocol (UP) for emotional disorders. Data were collected as part of a larger randomized clinical equivalence trial that assessed the efficacy of the UP, a transdiagnostic cognitive-behavioral therapy (CBT), relative to well-established single-disorder protocols and a wait-list control. The present…
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Anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic paravertebral block for postoperative analgesia after laparoscopic nephrectomy: a randomized non-inferiority trial
CONCLUSIONS: At 24-h postoperatively, QLB-LSAL had analgesic effects that were not inferior to those of TPVB for patients undergoing laparoscopic nephrectomy.
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Zanubrutinib, lenalidomide and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone as initial treatment in non-germinal center B-cell diffuse large B-cell lymphoma: a multi-center phase 2 study by Jiangsu Cooperative Lymphoma Group (JCLG)
CONCLUSIONS: ZR2-CHOP demonstrated promising efficacy and manageable toxicity in newly diagnosed non-GCB DLBCL.
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Effect of intrapulpal cryoanesthesia on intraoperative pain during root canal treatment in mandibular molars: a double blinded randomized control trial
To evaluate the impact of cooling the anesthetic solution prior to administering intra-pulpal anesthesia on the severity of intraoperative pain during root canal treatment in mandibular molars with symptomatic irreversible pulpitis and symptomatic apical periodontitis. Forty patients with mandibular molars diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis received root canal treatment by a…
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Evaluating the Efficacy of a Digital Therapeutic Intervention for Temporomandibular Disorders: Multicenter, Randomized, Sham-Controlled Trial
CONCLUSIONS: This randomized, sham-controlled trial demonstrated that a mobile-based DTx intervention led to significant improvement in pain at 6 weeks compared with sham control, with additional benefits in jaw function and oral behaviors, although no significant between-group difference was observed in psychological distress. These findings suggest that DTx interventions may serve as a promising and…
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Comparation of anterior maxilla and whole maxilla clockwise rotation to improve paranasal aesthetic defects of skeletal Class Ⅲ maxillofacial deformity
CONCLUSION: Compared with whole maxilla clockwise rotation, anterior maxilla clockwise rotation combined with segmental Le Fort Ⅰ osteotomy can increase the saggital displacement of the paranasal soft tissue, correct labial inclination of the upper incisors and the acute naso-labial angle and better improve the paranasal aesthetic defects in patients with Class Ⅲ maxillofacial deformity with…
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Effects of kinesiotaping combined with physical therapy in patients with migraine-associated neck pain: a randomized controlled study
CONCLUSION: The findings suggest that KT combined with PT and pharmacological treatment significantly improves clinical outcomes in migraineurs with neck pain. Specifically, the TG demonstrated greater reductions in intensity of headache and neck pain, along with increases in PPT and improvements in disability and QoL compared to both groups. These results can support the potential…
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Brexpiprazole for the Treatment of Co-occurring Schizophrenia and Substance Use Disorder: A Multisite, Randomized, Controlled Trial
Objective: This proof-of-concept study examined the effects of brexpiprazole treatment on substance use, psychiatric symptoms, and quality of life in patients with co-occurring schizophrenia and substance use disorder.
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Safety and efficacy of ranibizumab combined with dexamethasone intravitreal implant versus ranibizumab monotherapy for macular edema secondary to retinal vein occlusion: a 12-month prospective, randomized study
CONCLUSION: Combination therapy with ranibizumab and a dexamethasone implant provides superior visual outcomes and reduces the treatment burden compared to ranibizumab monotherapy for RVO-ME over 12 months. The safety profile was favorable, though monitoring for ocular hypertension is necessary. These benefits are particularly significant for patients with BRVO-ME.