Clinical Trials
Category Added in a WPeMatico Campaign
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Comparison of Oral Desensitization with Heated Cow’s Milk Products with Conventional Desensitization Method in Children with Cow’s Milk Allergy
Cow’s milk allergy (CMA) is one of the most prevalent Immunoglobulin E (IgE)-dependent food allergies in children. Currently, the only accepted treatment for food allergy is avoiding the relevant allergen. The purpose of this study is to investigate the immunological changes following the consumption of heated cow’s milk products compared to the usual method of…
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Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study
Endurance exercise may be associated with acute damage to intestinal epithelial cells. The effect of caffeine supplementation, and whether this is influenced by common genetic polymorphisms (ADORA2A: rs5751876 and CYP1A2: rs762551), is not currently known. Participants (n = 18 men and women) ingested caffeine (3 mg/kg body mass) or placebo 45 min before cycling (20…
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TRPM8 Agonist (Cryosim-1) Cream for Chronic Prurigo: A Randomized, Vehicle-controlled Trial
Chronic prurigo (CP) is a distressing dermatological condition lacking effective topical therapies. This randomized, double-blind, vehicle-controlled trial evaluated the efficacy and safety of Cryosim-1, a TRPM8 agonist cream, in 30 adults with CP. Participants were assigned to apply Cryosim-1 0.1%, 0.5%, or vehicle cream 3 times daily for 4 weeks. Both active formulations significantly reduced…
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Tripartite strategy for dual reduction of radiation and iodine dose in obese CCTA: High-iodine contrast, 80 kVp, and deep learning reconstruction
Coronary CT angiography (CCTA) in obese patients is challenging due to high radiation exposure, elevated iodine load, and increased image noise. We evaluated a tripartite low-dose strategy combining high-iodine-concentration contrast media (HCM, 400 mgI/mL), 80-kVp scanning, and deep learning image reconstruction (DLIR) in obese patients (BMI ≥30 kg/m2) to simultaneously reduce radiation and iodine dose…
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Effects of psycho-cardiology care on psychological and clinical outcomes among primary aldosteronism patients undergoing adrenal vein sampling: A randomized controlled study
Adrenal vein sampling (AVS) is considered the gold standard for the subtyping diagnosis of primary aldosteronism (PA), which is essential for preventing adverse cardiovascular outcomes. Nevertheless, the AVS procedure might induce anxiety in patients with PA because of discomfort and the uncertainty of the outcome. Therefore, this study aimed to assess the effectiveness of psycho-cardiology…
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Clinical application of Chester Step Test in developing personalized exercise prescription in patients with type 2 diabetes: A single-blind, randomized controlled trial
CONCLUSIONS: Under free-living conditions, the personalized exercise prescription based on CST effectively reduced glycemic variability in T2D patients.
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An extended cost-effectiveness analysis of decentralised TB diagnostic testing with Molbio Truenat MTB/RIF versus hub-and-spoke GeneXpert MTB/RIF in Mozambique and Tanzania
CONCLUSION: The intervention reduced patient costs and improved outcomes across SES groups. Decentralised TB testing with the Molbio Truenat platform is both cost-saving and more effective and cost-effective compared with a hub-and-spoke model in Mozambique and Tanzania.
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Mobile App-Guided Exposure Therapy for Panic Disorder With and Without Agoraphobia: Randomized Controlled Trial
CONCLUSIONS: Our findings suggest that app-guided exposure therapy can be a useful further treatment option in addition to established psychological and pharmacological strategies. However, superiority compared to the disorder-unspecific meditation app remains unclear.
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Concentration-QTc Analysis of Valemetostat in Patients With Hematologic Malignancies
This study assessed the potential risk of QT prolongation associated with the dual enhancer of zeste homolog 1/2 inhibitor valemetostat. An evaluation of the relationship between plasma valemetostat concentration and heart-rate-corrected QT (QTc) interval was performed. Time-matched plasma concentration and 12-lead electrocardiogram data were collected from the phase I studies DS3201-A-J101, in patients with relapsed/refractory…
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Application of the theory of planned behavior in self-care behaviors of knee osteoarthritis in the rural older people
CONCLUSION: The results showed that the use of TPB contributed to the improvement of self-care for knee osteoarthritis in older people. Due to the importance of health education in promoting self-care behaviors and preventing complications, longer interventions with the aim of preventing the complications of knee osteoarthritis in older people are suggested.