Clinical Trials
Category Added in a WPeMatico Campaign
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Communication About Sexuality (COSY) Encourages Physical Activity in COPD: A Randomised Trial
CONCLUSION: Communication about sexual wellbeing using the COSY instruments was well received by people with COPD and enable healthcare professionals to comfortably address an often-ignored topic. Recruitment challenges limited study power, but the findings offer strong justification for further research into this promising and needed holistic care approach.
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Effect of pharmacist-led medication reviews on appropriateness of prescribing in patients with dementia — results from the cluster randomized controlled «DemStepCare» study
CONCLUSION: Even a single comprehensive medication review significantly improved medication appropriateness in PwD. Based on the results, pharmacist-led medication reviews are strongly recommended for PwDs.
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Effectiveness of a digital game based study guide on head trauma assessment on knowledge and practical skills of nursing students: a quasi-experimental study
CONCLUSION: The study shows that a digital game-based study guide significantly enhances nursing students’ knowledge and skills in head trauma assessment.
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Net Water Uptake at CT Predicts the Treatment Effect of Thrombectomy for Low ASPECTS Stroke
Background Recent trials have demonstrated that supplementing best medical treatment (BMT) with endovascular thrombectomy (EVT) improves the functional outcomes of patients presenting with large ischemic lesions. Purpose To analyze whether net water uptake (NWU), quantified as infarct hypoattenuation at admission noncontrast CT, modifies the treatment effect of EVT and may aid in patient selection. Materials…
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Is the neighbourhood environment associated with indicators of health in children and adolescents? Developing and testing a new proof-of-concept Healthy Environments Index for Children in Taranaki, New Zealand
CONCLUSIONS: The theory-informed HEIC and its two subindices may be useful tools for policy and practice aiming at improving child health outcomes. However, they require validation in larger studies in other areas of New Zealand.
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Effectiveness of educational intervention on cervical cancer screening knowledge, attitude, and practice among Yemeni immigrant women in Klang Valley, Malaysia: a randomized controlled trial
CONCLUSIONS: Online educational intervention was effective in improving women’s knowledge, attitudes, and practices regarding cervical cancer and its screening.
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Group Cognitive Behavioral Therapy With Virtual Reality Exposure Versus In-Vivo Exposure for Social Anxiety Disorder and Agoraphobia: Underpowered Results From the SoREAL Pragmatic Randomized Clinical Trial
CONCLUSIONS: Due to insufficient recruitment and substantial missing data, no definitive conclusions can be drawn regarding group differences between VR-CBT and traditional CBT in group settings. The feasibility issues encountered suggest that careful consideration of the benefits and limitations of VR technology is essential before implementation in clinical practice.
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Eppikajutsuto for Treatment of Lymphatic Malformations in Children: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this nonrandomized clinical trial of children with LMs, eppikajutsuto was associated with a reduction in lesion volume and was well tolerated. Further studies, including randomized clinical trials, are warranted to confirm these findings.
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Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype
CONCLUSION: Significant differences in microbial composition and function were observed across age groups and constipation subtypes in FC, suggesting underlying pathophysiological heterogeneity and providing a basis for precision diagnosis and treatment.
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Proteins linked to type II interferon response in Sjögren’s disease: novel indicators for disease monitoring and predicting treatment response to leflunomide and hydroxychloroquine combination therapy
CONCLUSION: These data support a significant role for a type II IFN-associated immune response in SjD pathogenesis, which is targeted by LEF/HCQ. Proteins associated with type II IFN-driven immune responses hold potential to monitor disease activity and predict treatment response.