Clinical Trials
Category Added in a WPeMatico Campaign
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Efficacy and Safety of Non-Cross-Linked Hyaluronic Acid Mesotherapy for Post-Acne Erythema: A Split-Face, Prospective, Randomized, Single-Center Trial
CONCLUSION: According to the results of this study, non-cross-linked HA mesotherapy is a promising and useful therapeutic option for PAE.
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Clinical controlled study of Zhongyi Ointment() in the treatment of Kellgren-Lawrence grade knee osteoarthritis with moderate-to-severe pain
CONCLUSION: Zhongyi Ointment() can rapidly and significantly improve symptoms in patients with K-L gradeⅡknee osteoarthritis with moderate-to-severe pain during the acute exacerbation stage, with definite short-term efficacy and favorable safety. Continuous treatment helps to consolidate the therapeutic effect and warrants further validation through multicenter studies with large sample sizes, as well as investigations into the…
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Nutrition-sensitive agriculture programme impacts women’s mental health via food security in rural Bangladesh
CONCLUSIONS: On average, intervention participants had better mental health 1 year after the programme ended, with some of the effect mediated by increased food security. There are likely other pathways through which nutrition-sensitive agriculture can improve mental health, such as social protection and income, which may act synergistically.
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Effects of a Web-Based Intercultural Midwifery Training Program on Cultural Sensitivity and Intercultural Effectiveness Among Midwifery Students: A Multicenter Randomized Controlled Trial
CONCLUSION: A web-based intercultural midwifery training program seems to be an effective approach for increasing the cultural sensitivity and intercultural effectiveness of midwifery students.
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Effects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial
CONCLUSION: Acute post-exercise HMB-FA supplementation in elite judo athletes did not significantly influence muscle damage or oxidative stress markers but transiently increased antioxidant enzyme activities (CAT, GPX, and SOD). These findings suggest an enzyme-specific effect and highlight the need for future studies using more precise oxidative-stress markers and cellular assays to better evaluate antioxidant responses;…
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Theoretical Cost-Effectiveness of PCSK9 Inhibitors in Stroke Due to Intracranial Atherosclerosis
CONCLUSIONS AND RELEVANCE: This theoretical framework suggests that alirocumab and evolocumab were cost-effective for preventing recurrent stroke in patients with severe intracranial atherosclerosis, with all agents cost-effective under current cost-sharing programs offered by commercial and Medicare plans.
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Effects of incentive spirometer added to standard rehabilitation in previously hospitalized adults with post-COVID-19 condition: a randomized controlled trial
CONCLUSION: Adding incentive spirometry to standard rehabilitation improved peak expiratory flow and reduced dyspnoea in adults with post-COVID-19 condition, supporting its use as a low-cost adjunct for respiratory symptom management.
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Serum Biomarkers and CT-Derived Muscle Indices in Sarcopenia Associated with Pancreatic Neoplasm: A Comparative Clinical Study
Background: Sarcopenia is a frequent and clinically relevant condition in patients with pancreatic neoplasm, contributing to poor prognosis, reduced therapeutic tolerance, and increased mortality. The identification of reliable circulating biomarkers, alongside imaging-based muscle assessment, may improve early detection and risk stratification. Methods: This randomized prospective study included 61 patients, of whom 36 had pancreatic neoplasm…
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Phase II trial of combination radiation, hormone, and immunotherapy in grade group 5 prostate cancer
CONCLUSIONS: Nivolumab combined with SOC was associated with encouraging FFBR in this high-risk GG5 PCa population and may represent a promising therapeutic intensification strategy. The Decipher immunosuppression score may serve as a predictive biomarker for response. These findings warrant further investigation in randomized trials.
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Evaluating the effects of trifocals and extended depth of focus intraocular lens implantation on stereopsis and contrast sensitivity in cataract patients
CONCLUSION: Both IOLs provided good stereopsis and contrast sensitivity in the early postoperative period. However, by 1 month, EDOF IOLs demonstrated significantly better stereopsis and improved contrast sensitivity.