Clinical Trials
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Application value of fibro-bronchoscopic cryosurgery combined with medication in the treatment of tracheobronchial tuberculosis
CONCLUSION: The application of fibro-bronchoscopic cryosurgery combined with topical administration on the basis of conventional anti-TB treatment can improve the clinical efficacy of TBTB patients and shorten the duration of treatment without increasing the incidence of adverse reactions.
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Ethnic Sensitivity Assessment of Mosunetuzumab Pharmacokinetics and Pharmacodynamics in Chinese Patients With Relapsed or Refractory Follicular Lymphoma
Mosunetuzumab, a CD20 × CD3 T-cell-engaging bispecific antibody, redirects T cells to eliminate malignant B cells. The purpose of YO43555 was to assess the pharmacokinetics (PK), safety, tolerability, and efficacy of mosunetuzumab as a single agent in Chinese patients with relapsed/refractory follicular lymphoma (R/R FL). The impact of ethnicity/region on the PK disposition of mosunetuzumab…
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Health Care Resource Utilization for Patients With Suspected Myocardial Infarction: A Secondary Analysis of the RACE-IT Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This secondary analysis of a randomized clinical trial of a 0/1-hour hs-cTnI protocol to rule out MI in the ED found that there was a reduction in cardiac evaluations and ED length of stay without increasing revascularization rates compared with the standard 0/3-hour hs-cTnI protocol. This approach could optimize health care resources…
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Impact of resistance training on inflammatory biomarkers and associations with treatment outcomes in colon cancer
CONCLUSION: Inflammatory markers in patients with colon cancer undergoing adjuvant chemotherapy were not significantly impacted by randomization to a resistance training program but were associated with baseline body composition measures. Further investigations are needed to better elucidate the potential role of inflammatory markers and body composition in predicting important treatment outcomes.
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The effectiveness of a mindfulness-based stress reduction (MBSR) programme for parents of children with attention deficit hyperactivity disorder (ADHD): a pilot randomized controlled trial
CONCLUSION: The pilot study revealed that MBSR is feasible and acceptable for parents of children with ADHD in Chinese culture. The findings also suggested that the MBSR programme was effective in reducing parental stress and enhancing mental well-being. This study was registered in the National Library of Medicine, National Center for Biotechnology Information Clinical Trials…
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Effect on preoperative anxiety of a personalized three-dimensional kidney model prior to nephron-sparing surgery for renal tumor: study protocol for a randomized controlled trial (Rein 3D Print-Anxiety — UroCCR 113)
BACKGROUND: The announcement of a diagnosis can be a source of anxiety for patients. Managing this anxiety is a major challenge, in terms of quality of life but also for the use of anxiolytic and analgesic therapies. The use of 3D modeling technology in partial nephrectomy surgery has proved its worth as a surgical aid…
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Evaluation of augmented lateral rectus recession by hang back and Z-tenotomy for correction of large-angle exotropia
CONCLUSIONS: Augmented LR recession with hang-back is an effective and safe procedure for the treatment of large-angle exotropia up to 90 PD, whereas Z- tenotomy is another augmentation technique for exodeviation angles less than 45 PD.
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Effects of exercise on cognition and Alzheimer’s biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study
INTRODUCTION: The EXERT study (Exercise in Adults with Mild Memory Problems) was a Phase 3, multicenter, randomized controlled trial that examined effects of exercise on cognition and other measures of brain health in sedentary older adults with amnestic mild cognitive impairment (MCI).
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Effect of Upper Body Flexibility Exercises on Respiratory Muscle Performance, Upper Limb Endurance and Activities of Daily Living in Patients With Chronic Respiratory Disease-A Randomized Control Trial
BACKGROUND AND PURPOSE: Patients with chronic respiratory disease (CRD) often rely on neck muscles for breathing and contribute to poor posture, which alters the length-tension relationship and efficiency of these muscles. Upper body flexibility and good posture can potentiate pulmonary rehabilitation (PR) protocol. The present study aims to evaluate if the addition of upper body…
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The longitudinal impact of low-dose morphine on diurnal cortisol profiles in people with chronic breathlessness and chronic obstructive pulmonary disease (COPD): an exploratory study
INTRODUCTION: Stress activates the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is an end product. ‘Allostatic load’ is where systems including the HPA axis are exposed to high, cumulative, physiologic burdens (such as chronic breathlessness) leading to flatter diurnal cortisol slopes and poorer health outcomes. The aim of this hypothesis-generating study explored longitudinal changes in cortisol…