Clinical Trials
Category Added in a WPeMatico Campaign
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Phase II Study to Evaluate the Safety and Efficacy of Neoadjuvant Chemotherapy with Weekly Paclitaxel and Carboplatin Followed by Radical Chemoradiation in Locally Advanced Cervical Cancer in Egyptian Population
CONCLUSION: NACT with dose dense protocol, followed by CCRT, is a treatment option for locally advanced cervical cancer with controllable adverse events and agood response rate.
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Predicting treatment outcome for complex posttraumatic stress disorder using the personalized advantage index
ABSTRACTBackground: Ample studies have demonstrated the effectiveness of psychotherapy for posttraumatic stress disorder (PTSD). However, large individual variation in treatment outcome remains unsolved and treatment options for complex posttraumatic stress disorder (CPTSD) are debated. There is a need for exploring methods for matching patients with treatment they will most likely benefit from.Objective: To develop a…
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Prospective phase II trial of first-line rituximab, methotrexate, and orelabrutinib (R-MO) in primary central nervous system lymphoma
The treatment of primary central nervous system lymphoma (PCNSL) is currently limited by the impermeability of the blood-brain barrier. This study aims to assess the efficacy and safety of the R-MO regimen (rituximab, high-dose methotrexate, and orelabrutinib) in the treatment of patients with newly diagnosed PCNSL. A total of 37 patients were enrolled in this…
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Reliability and Acute Changes in the Load-Velocity Profile During Countermovement Jump Exercise Following Different Velocity-Based Resistance Training Protocols in Recreational Runners
This study aimed (i) to explore the reliability of the load-velocity relationship variables (load-axis intercept [L(0)], velocity-axis intercept [v(0)], and the area under the load-velocity relationship line [A(line)]) obtained during the countermovement jump exercise in successive sessions and (ii) to examine the feasibility of the load-velocity relationship variables to detect acute changes in the lower-body…
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An internet-delivered psychoeducational intervention (Fex-Can 2.0) targeting fertility-related distress and sexual dysfunction in young adults diagnosed with cancer: Study protocol of a randomized controlled trial with an internal pilot phase
CONCLUSIONS: This randomized controlled trial aims to evaluate whether Fex-Can 2.0 is superior to standard care, in terms of reducing fertility-related distress and sexual dysfunction in young adults diagnosed with cancer. If proven efficacious, the Fex-Can 2.0 intervention may be a valuable resource in health care, with the potential to significantly improve the care of…
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Long-Term Efficacy and Cost-Effectiveness of Laser Tonsillotomy vs Tonsillectomy: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: The findings of this trial suggest that both CO2 laser TO and TE under general anesthesia significantly reduced long-term symptoms, with greater reduction after TE. TO had lower cost and similar patient satisfaction. Based on these findings, CO2-laser TO appears to be a safe, effective, and cost-effective method for long-term relief of…
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Efficacy and Safety of Fexuprazan Versus Esomeprazole for Gastroesophageal Reflux Disease-Related Chronic Cough: A Randomized, Double-Blind, Active-Controlled Exploratory Trial
CONCLUSION: These findings support the potential of P-CABs as a promising alternative to PPIs for patients with chronic cough requiring acid-suppressive therapy.
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Efficacy and Safety of Generic Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream Compared With TRI-LUMA for the Treatment of Moderate-To-Severe Melasma in Chinese Patients: A Randomized, Single-Center, Placebo-Controlled Trial
CONCLUSION: Generic TCC was as effective as TRI-LUMA and had a similar safety profile in this study of Chinese subjects with moderate-to-severe melasma.
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Original pericostal suture sparing the neurovascular bundle for prevention of post-thoracotomy pain syndrome after video-assisted mini-thoracotomy
CONCLUSION: Original pericostal suture with subperiosteal canal through detachment of neurovascular bundle from the underlying rib reduces the incidence of post-thoracotomy pain syndrome.
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Dronedarone provides effective early rhythm control: post-hoc analysis of the ATHENA trial using EAST-AFNET 4 criteria
CONCLUSION: These data support the use of dronedarone for early rhythm control therapy in selected patients with early AF.