Clinical Trials
Category Added in a WPeMatico Campaign
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One-Year Trajectory of Pain, Function, and Health-Related Quality of Life in Patients With Plantar Fasciopathy
CONCLUSIONS: Different recovery trajectories are important to consider when determining timepoints for follow-up in scientific studies as well as to individualize the clinical follow-up.
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Quantifying Risk of Delayed QT Prolongation of Ipatasertib in Preclinical and Clinical Studies in Cancer Patients
QTc prolongation has been associated with torsades de pointes (TdP) and also with other cardiac diseases. We investigated the effect of ipatasertib, a selective serine/threonine kinase (AKT, protein kinase B) inhibitor, on preclinical models of QTc prolongation as well as across two clinical studies. Preclinical in vitro studies suggested that ipatasertib and its metabolite, M1,…
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Enhancing self-care in post-MI patients: a family-supported educational intervention based on the theory of planned behavior
CONCLUSION: The TPB-based educational intervention can meaningfully improve the self-care behavior of MI patients. Future work should assess the sustainability over time of these changes, and the feasibility of using digital health technology to support enhanced patient compliance.
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Effectiveness and safety of a hydrophobic aspheric monofocal intraocular lens with molding process for cataract surgery
CONCLUSION: The novel SM60AS IOL demonstrated satisfactory effectiveness and safety, with clinical outcomes comparable to those of the established control IOL in cataract surgery.
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Effect of A Patient Reminder Program on Adherence in Postmenopausal Women with Osteoporosis Receiving Oral Bisphosphonate Treatment: A Randomized Clinical Control Trial
Poor adherence to oral bisphosphonate therapy remains a major challenge in the treatment of osteoporosis, substantially reducing therapeutic efficacy. While reminder interventions have been proposed as a method to enhance adherence, evidence remains limited. This study aimed to evaluate the impact of written and verbal reminders on medication adherence compared to standard patient care over…
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Fall risk perception toolkit based on «digital human» for community-dwelling older patients with stroke: development and validation
CONCLUSION: FRP-digital human can be accepted by community-dwelling older patients with stroke and help improve their fall risk perception and quality of life. Moreover, the design of the WeChat mini program increased its generalizability to promote more successful health care delivery.
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Randomized clinical trial to evaluate the effectiveness of different thicknesses of stabilization splints in treating temporomandibular disorder using joint vibration analysis as a novel diagnostic tool
CONCLUSION: The study concluded that the splints given to Group A and Group B showed effective treatment response, while Group C showed positive response in a few individuals, but some individuals compliant of discomfort. The stress level was high in female individuals. Among all the participants, the concern of tooth wear was present.
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Effectiveness of a Machine Learning-Enabled Skincare Recommendation for Mild-to-Moderate Acne Vulgaris: 8-Week Evaluator-Blinded Randomized Controlled Trial
CONCLUSIONS: Using a machine learning model for personalized skincare recommendations significantly reduced symptoms and improved severity and overall QoL of patients with mild-to-moderate AV, supporting the potential of machine learning-based personalized treatment options in dermatology.
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Cost-effectiveness of the rural lifestyle eating and activity program (Rural LEAP)
Rural United States (U.S.) residents with obesity have unique challenges maintaining successful weight loss; tailored support resources such as individual behavioral coaching through telehealth are a cost-effective option. This study examined the cost-effectiveness of telephone-based individual coaching sessions for extended care after initial weight loss compared to an education-only control group. Trial data collected during…
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Using short video-based educational intervention to enhance initial acceptance to continuous positive pressure therapy in Thai obstructive sleep apnea patients in a tertiary care: a randomized controlled trial
CONCLUSION: Our data demonstrated a promising result of using a short-formed video education intervention to enhance CPAP usage in OSA patients. Longer-term studies with a larger population would provide more reliable outcomes. This trial was retrospectively registered with Thaiclinicaltrials.org. The trial registration number (TRN) was TCTR20240619006, and the registration date is 18 June 2024.