Clinical Trials
Category Added in a WPeMatico Campaign
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AI-enhanced guidance demonstrated improvement in novices’ Apical-4-chamber and Apical-5-chamber views
INTRODUCTION: Artificial Intelligence (AI) modules might simplify the complexities of cardiac ultrasound (US) training by offering real-time, step-by-step guidance on probe manipulation for high-quality diagnostic imaging. This study investigates real-time AI-based guidance tool in facilitating cardiac US training and its impact on novice users’ proficiency.
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A study protocol for the CHinA National CancEr screening (CHANCES) trial: a randomized controlled study to compare the screening strategies for lung cancer and colorectal cancer
BACKGROUND: Well-implemented cancer screening strategies can significantly enhance early detection rates, leading to improved treatment outcomes and reduced mortality. However, there remains a paucity of high-quality evidence from developing regions. The CHinA National CancEr Screening (CHANCES) Trial aims to comprehensively evaluate and compare different screening strategies for lung cancer and colorectal cancer (CRC) in the…
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Genomic testing for bleeding disorders (GT4BD): protocol for a randomised controlled trial evaluating the introduction of whole genome sequencing early in the diagnostic pathway for patients with inherited bleeding disorders as compared with standard of care
INTRODUCTION: The current diagnostic pathway for patients with a suspected inherited bleeding disorder is long, costly, resource intensive, emotionally draining for patients and often futile, as half of patients will remain without a diagnosis and be labelled ‘bleeding disorder of unknown cause’. Advances in understanding the genetic basis of the inherited bleeding disorders, coupled with…
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Effectiveness of theory-based breast self-examination intervention for breast cancer prevention among female college teachers in Pakistan: A cluster randomized controlled trial study protocol
BACKGROUND: Breast cancer poses a significant health challenge in Pakistan, with a disproportionately high number of cases diagnosed at advanced stages. Despite the rising incidence, preventative measures like regular screening remain not commonly practiced among Pakistani women. While extensive research exists on breast cancer globally, there is a critical gap in studies specifically designed and…
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A digital therapeutic for people with borderline personality disorder in Germany (EPADIP-BPD): a pragmatic, assessor-blind, parallel-group, randomised controlled trial
BACKGROUND: Fewer than 25% of patients with borderline personality disorder (BPD) receive guideline-adherent psychotherapy. Digital therapeutics can help reduce this gap. Therefore, we tested the effectiveness and safety of priovi, a digital therapeutic for BPD.
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Protocol MelatoSom-Kids-PTSD: sleep disturbances in children and adolescents with post-traumatic stress disorder (PTSD) — a randomized double-blind placebo-controlled trial to investigate the efficacy of paediatric prolonged-release melatonin
Introduction: Sleep disorders in the insomnia spectrum, as well as nightmares, are among the most sensitive and persistent symptoms in children with post-traumatic stress disorder (PTSD). There is currently no reference treatment or specific pharmacological treatment recommendation on the management of sleep disturbances in children and adolescents suffering from PTSD, despite the fact that they…
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Effects of an additional multimodal intervention (MultiMove) during inpatient rehabilitation on clinical and functional outcomes in patients with chronic low back pain- a pilot trial
CONCLUSION: Data indicate that the multimodal intervention MultiMove improved clinical and functional outcomes in CLBP patients during inpatient rehabilitation. Therefore, conducting a randomized controlled trial with a large sample size is recommended to verify and extent these results.
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Phantom-based training of ultrasound-guided breast biopsy in medical education: a randomized controlled trial comparing handheld and high-end ultrasound
CONCLUSIONS: Percutaneous biopsy performed by novices using HUDs is feasible, performance times, success rates, operability and the individually perceived workload were on par with HEUS-guidance. HUDs can be used as cost-effective tools for percutaneous biopsy training purposes in medical education.
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Comparative efficacy and safety of nalbuphine and hydromorphone in painless colonoscopy techniques: a randomized controlled trial
CONCLUSIONS: While nalbuphine and hydromorphone effectively maintain intraoperative vital signs, nalbuphine offers superior postoperative comfort. This makes nalbuphine a preferable analgesic choice in outpatient colonoscopy settings. Further research is warranted to determine the optimal dosages for both drugs and to explore their mechanisms of action in procedural pain management.
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Impact of fixed-point rotational reduction of the spine on pain scores and lower limb motor function in patients with lumbar facet joint disorder
CONCLUSION: The application of fixed-point rotational reduction of the spine has shown remarkable efficacy in alleviating pain among patients diagnosed with lumbar facet joint disorder. It also facilitates restoration of lumbar mobility, functional improvement, balance enhancement, and patient rehabilitation. These findings highlight its clinical relevance and potential for therapeutic intervention.