Clinical Trials
Category Added in a WPeMatico Campaign
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Point of care v/s central lab automated blood culture system in decreasing antibiotic usage in NICU: A randomized controlled trial
BackgroundAntibiotic usage is rampant in NICUs. The time of stoppage of antibiotics depends predominantly on clinical condition of the neonate and final blood culture report. Delay in availability of report due to lab logistics might delay the stoppage of antibiotic. Hence, we hypothesized that having a point of care BACTEC system in NICU premises might…
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Evaluation of a novel elbow joint torque measurement device in healthy subjects and stroke patients: a randomized trial
Current clinical practice lacks quantitative assessment methods for elbow joint movements. In response to existing research limitations, this study introduces the innovative elbow joint torque measurement device (EJTMD), which concurrently measures muscle strength and active range of motion (AROM) using a five-bar linkage system governed by a sliding mode control algorithm. Healthy subjects (n =…
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Comparing Effects of Caffeine and Total Motion Release Technique on Cognitive, Neuromuscular, and Anaerobic Function in Semi-Professional Male Sprinters: A Randomized Controlled Trial
BACKGROUND AND PURPOSE: As sprinting gains popularity, enhancing anaerobic capacity, neuromuscular function, and cognitive performance is crucial. This study evaluated the effects of Total Motion Release (TMR) and caffeine on these functions in male sprinters to optimize performance strategies.
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Indirect calorimetry and nitrogen balance guided nutrition therapy in ICU patients with acute kidney injury
Data on the benefits of early integration of indirect calorimetry (IC) for caloric guidance and maintaining a positive nitrogen balance in critically ill patients with acute kidney injury (AKI) are scarce. This study aimed to evaluate the impact of the nutritional therapeutic approach on mortality and renal outcomes in these patients. We conducted an open-label…
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Symptom Attribution, Help Seeking and Willingness to Undergo Diagnostic Investigations for Bowel Cancer Symptoms in People With Anxiety and/or Depression-A Vignette Study
CONCLUSIONS: People with A/D should be encouraged to take bodily changes typical of cancer seriously and be proactive in help seeking and taking tests. Clinicians need to be aware that people with A/D may misattribute bodily changes associated with cancer and support them to seek help and undergo testing.
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Measuring cognitive change in secondary progressive MS: an analysis of the ASCEND cognition substudy
CONCLUSIONS: Improvements in SDMT and PASAT performance were observed regardless of treatment arm. These findings are consistent with prior studies in MS. As it is unlikely that cognition improves over time in people with a chronic neurologic disease, these results support the need for cognitive outcomes that overcome practice and learning effects to accurately quantify…
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Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55-70 Years: A Randomised Controlled Parallel Trial
Background: Chronic inflammation increases morbidity in older adults and significantly impacts healthy ageing. Pomegranate extract (PE), rich in polyphenols, has been suggested to reduce inflammation and could prevent cardiovascular disease. However, there is limited research examining the potential of PE in disease prevention in ageing. Methods: A two-arm double-blind parallel trial was conducted, in which…
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Effect of Tadalafil on cardiac function and left ventricular dimensions in Duchenne muscular dystrophy: safety and cardiac MRI substudy results from a randomized, placebo-controlled trial
CONCLUSIONS: No adverse effects of tadalafil on cardiovascular function were evident based on adverse events, echocardiograms, ECG, or vital sign measurements through 48 weeks in patients with DMD. The small mean increases in LVID and LV volume observed with tadalafil are consistent with PDE5 inhibitor pharmacology, but their clinical relevance in the context of LV…
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Impact of an oral care intervention protocol on oral health outcomes in head and neck cancer patients undergoing radiation or chemoradiation therapy
CONCLUSION: These data suggest that the OCIP is clinically helpful in maintaining overall oral health among cancer patients receiving head and neck radiation/chemoradiation. The OCIP effectively delays the incidence of oral complications arising from head and neck radiation therapy/chemotherapy but does not prevent them. The findings of this study can also contribute to providing evidence…
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A proof of concept study on digital interventions for reducing socio-evaluative stress and anxiety in youth
Youth often struggle with heightened sensitivity to social judgement, increasing their vulnerability to fear in social situations. This study investigates brief digital interventions aimed at regulating cognitive and affective disturbances related to social anxiety, specifically focusing on fear responses in a social-evaluative threat context. One-hundred-twenty healthy youth were randomly assigned to one of four conditions:…