Clinical Trials
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Combination of fentanyl and metoprolol in anesthesia in elderly patients: Effects on postoperative pain management and cardiovascular stability
Elderly patients undergoing surgery may benefit from improved postoperative pain management and cardiovascular stability through the combination of metoprolol, a selective β1-adrenergic blocker and fentanyl, an opioid analgesic. This double-blind randomized controlled trial evaluated the efficacy of this combination in 200 elderly patients scheduled for elective surgeries. Participants were divided into two groups: The experimental…
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Efficacy of cyclosporine eye drops in managing post-cataract surgery dry eye symptoms: A randomized controlled trial
Many patients develop dry eye symptoms or further exacerbation post-cataract surgery. The aim is to analyse the efficacy of cyclosporine A (CsA) eye drops on the dry eye symptoms post-cataract surgery (DEPC). 100 DEPC patients admitted to First Affiliated Hospital of Gannan Medical University from August 2022 to August 2024 were randomly divided into control…
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The application of stay sutures in thoracoscopic esophageal repair for Type C esophageal atresia
CONCLUSION: This innovative approach significantly shortens the operative time in the thoracoscopic treatment of Type C EA.
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Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients
CONCLUSIONS: A significant relationship was observed between IJVV levels during deep inhalation and the blood pressure decline following propofol induction. Administering IJVV-A guided fluid infusion can significantly reduce propofol-induced hypotension by keeping the IJVV-A less than 23.42% during deep inspiration.
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Whole body MRI by MY-RADS for imaging response assessment in multiple myeloma
Minimal residual disease (MRD) testing has underpinned the evaluation and expansion of therapeutic options for patients with multiple myeloma (MM). Imaging is essential for evaluating residual disease status, overcoming sampling errors inherent with other MRD modalities. The accuracy of whole-body MRI (WB-MRI) has led to its incorporation into MM diagnostic imaging guidelines. We report here…
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Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
Objective: Vagus nerve stimulation (VNS) therapy is a long-term intervention for treatment-resistant major depression (TRD) adjunctive to treatment as usual (TAU). To enhance clinical decision- making, we identified subgroups that respond especially well or poorly with active VNS vs no stimulation sham VNS (prognostic predictors) and subgroups that specifically benefit from active VNS vs sham…
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Homelessness, Patient Navigation, and Lung Cancer Screening in a Health Center Setting: A Subgroup Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this subgroup analysis of a randomized clinical trial, patient navigation increased LCS participation among both patients currently and formerly experiencing homelessness; however, the effect size was smaller for those currently experiencing homelessness. Further improving cancer outcomes among HCH patients may require refinement of the patient navigation intervention, coupled with policy efforts…
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One-Year Trajectory of Pain, Function, and Health-Related Quality of Life in Patients With Plantar Fasciopathy
CONCLUSIONS: Different recovery trajectories are important to consider when determining timepoints for follow-up in scientific studies as well as to individualize the clinical follow-up.
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Quantifying Risk of Delayed QT Prolongation of Ipatasertib in Preclinical and Clinical Studies in Cancer Patients
QTc prolongation has been associated with torsades de pointes (TdP) and also with other cardiac diseases. We investigated the effect of ipatasertib, a selective serine/threonine kinase (AKT, protein kinase B) inhibitor, on preclinical models of QTc prolongation as well as across two clinical studies. Preclinical in vitro studies suggested that ipatasertib and its metabolite, M1,…
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Enhancing self-care in post-MI patients: a family-supported educational intervention based on the theory of planned behavior
CONCLUSION: The TPB-based educational intervention can meaningfully improve the self-care behavior of MI patients. Future work should assess the sustainability over time of these changes, and the feasibility of using digital health technology to support enhanced patient compliance.