Clinical Trials
Category Added in a WPeMatico Campaign
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Association of predicted lean body mass and fat mass with prognosis in patients with heart failure preserved ejection fraction
CONCLUSION: In patients with HFpEF, a higher FMI was strongly associated with increased risks of both the primary endpoint and all-cause mortality, while an elevated LBMI was associated with a reduced risk of mortality.
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Educational video combined with augmented clinical support to improve CPAP use in patients with obstructive sleep apnea-hypopnea syndrome: A randomized controlled trial protocol
CONCLUSION: We designed this original protocol by combining TPE with ACS. We hope that our findings will help us improve CPAP adherence among Tunisian patients with OSAHS.
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Initiating Injectable Buprenorphine in People Hospitalized With Infections: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial comparing initiation of LAB for OUD with ID management in the hospital setting compared with TAU, there was no difference between arms in the receipt of MOUD at 12 weeks. The TAU arm had higher retention than anticipated. These findings suggest that hospitalization with an infection related…
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A phase I/IIa trial of atorvastatin in Japanese patients with acute Kawasaki disease and coronary artery aneurysms
CONCLUSIONS: We found that atorvastatin was safe and a dose up to 0.5 mg/kg/day for 6 weeks was well-tolerated in Japanese children with acute KD and CAAs.
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Neuroprotective Activity of Rasayana Formulation and Effect of Shigru Pallava Eye Drops on Intraocular Pressure as an Add-on Therapy Compared to the Standard of Care in Primary Open-Angle Glaucoma: Protocol for an Exploratory, Open-label, Two-arm Randomized Controlled Trial
CONCLUSIONS: If shown to be effective, the combined RF and SP eye drops could enhance neuroprotection and further control IOP in POAG, thereby addressing a significant need in current glaucoma therapy. This trial may provide a foundation for larger-scale investigations into integrative treatments for glaucoma management.
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Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, controlled phase II clinical trial
CONCLUSIONS: Intrathecal BMMNC combined with an educational intervention improved disease severity and adaptability more than education alone in children with ASD.
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Effect of esketamine on postinduction hypotension in elderly patients undergoing elective noncardiac surgery: a secondary analysis of a randomized clinical trial
Postinduction hypotension (PIH) increases the risk of perioperative adverse events. This study aimed to test if low-dose esketamine could significantly decrease the incidence of PIH in elderly patients undergoing elective noncardiac surgery. This was a post hoc analysis of a randomized clinical trial in university-affiliated academic tertiary hospital. Patients (65 to 85 years, ASA physical…
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The efficacy of combined lateral and anterior quadratus lumborum blocks in postoperative pain management following pelvic tumor resection: a randomized controlled trial
CONCLUSION: The ultrasound-guided QLB demonstrated superior analgesic efficacy and reduced morphine consumption compared to patients without the block. Our findings provide evidence supporting the hypothesis that QLB is an effective component of multimodal analgesia for individuals undergoing pelvic tumor resection and reconstructive surgery.
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Changes in Daily Functioning in Association With Tau and Amyloid Among Unimpaired Older Adults With and Without Elevated Amyloid
BACKGROUND AND OBJECTIVES: Everyday functioning declines gradually over time in Alzheimer disease (AD), with the earliest changes potentially occurring at the preclinical stage. We investigated how changes in everyday functioning relate to (changes in) amyloid and tau in a large sample of cognitively unimpaired older adults, most of whom had elevated amyloid levels at the…
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The effect of traditional Thai massage vs routine physical therapy on gait pattern in spastic cerebral palsy: A cross-over randomized controlled trial
CONCLUSIONS: TM has a positive effect on gait performance, as indicated by GPS and increased activity in the right rectus femoris muscle when compared to PT. A large-scale non-inferiority trial is required to affirm the impact of TM.