Clinical Trials
Category Added in a WPeMatico Campaign
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Self-compassion mediates treatment effects in MDMA-assisted therapy for posttraumatic stress disorder
Background: Posttraumatic stress disorder (PTSD) is a severe condition often complicated by co-occurring disorders, such as major depression, alcohol use disorder, and substance use disorders. A well-powered phase 3 randomized, placebo-controlled trial has shown that MDMA-assisted therapy (MDMA-AT) may be an effective treatment for severe PTSD. However, the psychological mechanisms driving the therapeutic effects of…
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Effects of 12 weeks of Head-Down Strong Abdominal Breathing Training on Gait and Cognitive Function in Patients with Chronic Obstructive Pulmonary Disease
CONCLUSION: A 12-week HDBT program elevated cognitive function and improved stride length and speed metrics during an obstacle walking task in patients with stable COPD.
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Effect of inhibition of reactivated alcohol-associated memories with propranolol on alcohol craving
CONCLUSIONS: Our study demonstrated that propranolol administration after CS-induced retrieval could disrupt alcohol-associated memory reconsolidation and reduce alcohol craving. The finding provided a potential translational method to treat alcohol use disorder.
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Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation
INTRODUCTION: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear information, and timely, tailored consultations for their pain. This trial will evaluate the introduction of a…
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Timing of unsaturated fat intake improves insulin sensitivity via the gut microbiota-bile acid axis: a randomized controlled trial
The timing of dietary total fat intake influences glucose homeostasis, however, the impact of unsaturated fat (USFA) intake has yet to be explored. This 12-week, double-blind, randomized, controlled, 2 × 2 factorial-designed feeding trial investigated the effects of timing (lunch or dinner) and types of dietary USFA (high monounsaturated fat or polyunsaturated fat diet) intake…
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Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% for Acne: Results From A 6-Month Open-Label Study
BACKGROUND: Treatment of acne may require many months of treatment before maximal benefits are observed, and acne sequelae (eg, scarring, dyspigmentation) can persist long after lesion resolution. In 12-week clinical trials, triple-combination clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel (CAB) demonstrated efficacy and tolerability in the treatment of moderate to severe acne. This study assessed…
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Efficacy and Tolerability of a Cream in Aging Skin
CONCLUSIONS: The tested cream, which incorporates the ingredients mandelic acid and Centella asiatica, effectively improved participants’ skin appearance in adults with sensitive skin and moderate signs of aging.
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Blood pressure changes in patients after Minoxidil microinfusion to treat female pattern alopecia: analysis of a randomized, single blinded, placebo controlled clinical trial
CONCLUSION: Reduction of diastolic blood pressure in the minoxidil group proved dermal delivery and systemic absorption of the medication after scalp microinfusion. Increased systolic pressure in the control group may be related to pain during the procedure. BRAZILIAN REGISTRY OF CLINICAL TRIALS: (ReBEC): RBR-368fdb3; Date of registration: April, 11th, 2024 (retrospectively registered).
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Comparison of Electronic Surveillance With Routine Monitoring for Patients With Lymphoma at High Risk of Relapse: Prospective Randomized Controlled Phase 3 Trial (Sentinel Lymphoma)
CONCLUSIONS: The primary objective was not reached; however, patient-reported outcome measures remain essential for detecting adverse events in patients with cancer, and the electronic monitoring method needs to demonstrate its effectiveness and comply with international safety guidelines.
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The efficacy of narrowband ultraviolet B phototherapy combination with tofacitinib in the treatment of vitiligo: a randomized controlled trial
CONCLUSIONS: Our data suggest that UVB-TOF is potentially more effective than UVB alone in promoting recovery of vitiligo patients and reducing inflammatory factors.