Clinical Trials
Category Added in a WPeMatico Campaign
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Regional multi-center randomized trial of three vonoprazan-amoxicillin dosing regimens for Helicobacter pylori eradication in Sichuan Province, China
CONCLUSION: VPZ-AMO dual therapy achieved excellent eradication, safety, and patient compliance. All regimens were similarly effective, whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability, supporting its use as a first-line option in high-prevalence settings.
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Functional, Radiological, and Scapular Motion Evaluation of Surgical Versus Nonsurgical Treatment of Type 3 Acromioclavicular Dislocations: A Randomized Controlled Trial With 24 months’ Follow-up
CONCLUSION: Surgical management of type 3 AC joint dislocations resulted in similar DASH scores and range of motion compared with nonoperative management, although some secondary outcomes-including higher UCLA scores and cosmetic satisfaction scores-favored surgery.The trial was registered in the Brazilian Registry of Clinical Trials (RBR-4r6jhy6).
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Telehealth insulin titration in adults with diabetes: a randomized controlled trial comparing bluetooth-enabled versus traditional glucometers
CONCLUSION: BTG did not demonstrate glycemic superiority over TG in telehealth insulin titration; however, its association with reduced emergency department visits suggests potential benefits for healthcare utilization. Future studies should investigate the integration of BTG with comprehensive diabetes care platforms, with a focus on long-term outcomes and cost-effectiveness.
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Clinical effectiveness of early surgical fixation versus cast immobilization for adults with a scaphoid waist fracture: five-year follow-up of the Scaphoid Waist Internal Fixation for Fractures Trial
CONCLUSION: The clinical effectiveness of the two forms of treatment remained similar at five years. The recommendation that adult patients with a fracture of the waist of the scaphoid which is displaced by ≤ 2 mm should be treated inially with immobilization in a cast, followed by early fixation of a nonunion, is further corroborated…
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Impact of Real-Time, On-Demand Influenza and Respiratory Syncytial Virus Testing at Point-of-Care on Antibiotic Prescribing and Clinical Outcome in Pediatric Outpatients With Acute Respiratory Illness: A Prospective, Quasi-Randomized, Controlled Study
CONCLUSIONS: Use of Xpert Xpress Flu/RSV at point-of-care in pediatric outpatients with ARI reduced antibiotic prescription, which has the potential to improve antibiotic stewardship.
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Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain
Background: Compared with normal weight, obese individuals display a variety of deviant measures in neuroenergetic status, food intake behavior, glucose metabolism, and circulating vitamin C levels. A chronically lowered neuroenergetic content is associated with increased food intake and disturbed glucose metabolism in obesity. In turn, a vitamin C deficiency found in obesity may be connected…
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Effects of Individualized Step Targets on Physical Activity in COPD. A Randomized Study
CONCLUSION: Providing individualized step targets did not increase the proportion of subjects who achieved their targets, but it increased their step counts after six months. GDF-15 may be involved in the increase in the step count.
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Nutrition Counseling Frequency and Telehealth Integration on Cardiometabolic Outcomes in Metabolic Syndrome: A Randomized Controlled Trial in Turkey
Background and Objectives: As the demand for dietitian services continues to grow in high-volume healthcare settings, optimizing both the frequency and modality of follow-up has become crucial for sustaining and enhancing the effectiveness of medical nutrition therapy (MNT). This study evaluated a stepwise intensification model ranging from quarterly in-person visits to monthly in-person visits and…
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Feasibility and Usability of an mHealth App (mLab+) to Guide Users Through HIV and Syphilis Self-Testing: Pilot Randomized Controlled Trial
CONCLUSIONS: The findings support the use of the mLab+ app as a tool for assisting consumers in self-testing for HIV and syphilis. The limitations of the study design warrant further examination outside of clinic settings to better understand the utility of these tools for improving consumer health outcomes.
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Functional and cosmetic advantages of gasless endoscopic thyroidectomy in papillary thyroid carcinoma: a randomized trial
CONCLUSION: Compared with OP, ESSA is equally safe and effective, but more cosmetic and conducive to preserving functions of the anterior cervical region. ESSA can be considered an alternative approach to OP in hemithyroidectomy and CND.