Clinical Trials
Category Added in a WPeMatico Campaign
-
Impact of a Novel Dietary Supplement on Efficacy of Pharmacological Treatments for Androgenic Alopecia: A Real-Life, Multicenter, Randomized, Assessor-Blinded Trial on 225 Subjects
CONCLUSION: Oral supplementation of AGA-P significantly increases the clinical efficacy of pharmacological treatments for mild-to-severe AGA/FAGA (Study Registration: ISRCTN-19671217).
-
Comparison of clinical effects of aspherical monofocal and Tecnis ZMB00 multifocal intraocular lenses in patients with age-related cataract
CONCLUSIONS: The multifocal intraocular lens outperformed the aspherical monofocal intraocular lens in improving the vision-related quality of life and rate of spectacle independence. However, it had dark vision defects and optical side-effects.
-
The MAR method versus the visual estimation method in predicting external blood loss: a randomized controlled study
Accurately estimating blood loss is critical for managing hemorrhagic shock in prehospital and hospital settings. The Visual Estimation (VE) method is widely used, while the MAR method proposes using a fist measurement to estimate external blood on flat surfaces. A randomized, double-blind, parallel-group, controlled, and educational study was conducted involving 140 medical and paramedic students.…
-
The Impact of Nurse-Led Intervention on Breast Cancer Screening and Early Detection in China: Randomized Control Trial
CONCLUSION: This study provides information for future research and development of an educational intervention for breast cancer screening among Chinese women.
-
Doctor’s Counselling Using Culturally Responsive Pamphlet Increased Mammogram Uptake among Malay-Muslim Women in Singapore: A Randomized Controlled Trial in a Primary Healthcare Clinic
CONCLUSION: Cue to action from doctor led to increased mammogram uptake among Malay-Muslim women. Future interventions to promote screening should include doctors and religious leaders to further improve mammogram uptake, and change knowledge, perception, and beliefs.
-
Impact of changes in conventional risk factors induced by once-weekly GLP-1 receptor agonist exenatide on cardiovascular outcomes: an EXSCEL post hoc analysis
CONCLUSIONS: These model simulations explain only a modest proportion of the impact of observed EQW-induced changes in conventional CV risk factors on EXSCEL outcomes, apart from hHF and MI. Up to 1-year changes in conventional risk factors did not mediate the observed ACM risk reduction.
-
Randomized, controlled trial to analyze the effect of using a traction-bed-device on patients suffering from osteoarthritis/spondylosis of the lumbar spine
CONCLUSIONS: The presented results show that an additional traction device can improve pain score, function, clinical scores as well as improvements in quality of life in patients with spondylosis.
-
Orthostatic Systolic Blood Pressure Elevation and Incident Atrial Fibrillation: Insights From the SPRINT Trial
Exaggerated orthostatic changes in systolic blood pressure (SBP) were associated with adverse cardiovascular events. We aim to assess the association between orthostatic SBP changes and incident atrial fibrillation (AF). We performed a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial). Orthostatic SBP changes were defined as standing SBP minus seated SBP. Patients were…
-
Financial Incentives to Increase Diversity of Older Participants in a Memory Concerns Registry: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, relative to message invitations, invitations with guaranteed, small financial incentives but not lottery incentives increased enrollment of economically but not necessarily racially or ethnically diverse participants to a study that aimed to increase enrollment in clinical studies.
-
Patient-reported outcomes and home-based self-swabs for influenza-like illness events — lessons learned from the 2023/2024 DANFLU-2 Homeswab PRO substudy
CONCLUSION: The study confirmed the feasibility of using home-based self-swabs for remote disease diagnosis and digital PRO tracking for symptoms during ILI events in a large-scale, pragmatic randomized trial. While the approach proved viable, the findings also highlighted areas for improvement in participant engagement and data collection efficiency.