Clinical Trials
Category Added in a WPeMatico Campaign
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Effect on preoperative anxiety of a personalized three-dimensional kidney model prior to nephron-sparing surgery for renal tumor: study protocol for a randomized controlled trial (Rein 3D Print-Anxiety — UroCCR 113)
BACKGROUND: The announcement of a diagnosis can be a source of anxiety for patients. Managing this anxiety is a major challenge, in terms of quality of life but also for the use of anxiolytic and analgesic therapies. The use of 3D modeling technology in partial nephrectomy surgery has proved its worth as a surgical aid…
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Evaluation of augmented lateral rectus recession by hang back and Z-tenotomy for correction of large-angle exotropia
CONCLUSIONS: Augmented LR recession with hang-back is an effective and safe procedure for the treatment of large-angle exotropia up to 90 PD, whereas Z- tenotomy is another augmentation technique for exodeviation angles less than 45 PD.
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Effects of exercise on cognition and Alzheimer’s biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study
INTRODUCTION: The EXERT study (Exercise in Adults with Mild Memory Problems) was a Phase 3, multicenter, randomized controlled trial that examined effects of exercise on cognition and other measures of brain health in sedentary older adults with amnestic mild cognitive impairment (MCI).
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Effect of Upper Body Flexibility Exercises on Respiratory Muscle Performance, Upper Limb Endurance and Activities of Daily Living in Patients With Chronic Respiratory Disease-A Randomized Control Trial
BACKGROUND AND PURPOSE: Patients with chronic respiratory disease (CRD) often rely on neck muscles for breathing and contribute to poor posture, which alters the length-tension relationship and efficiency of these muscles. Upper body flexibility and good posture can potentiate pulmonary rehabilitation (PR) protocol. The present study aims to evaluate if the addition of upper body…
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The longitudinal impact of low-dose morphine on diurnal cortisol profiles in people with chronic breathlessness and chronic obstructive pulmonary disease (COPD): an exploratory study
INTRODUCTION: Stress activates the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is an end product. ‘Allostatic load’ is where systems including the HPA axis are exposed to high, cumulative, physiologic burdens (such as chronic breathlessness) leading to flatter diurnal cortisol slopes and poorer health outcomes. The aim of this hypothesis-generating study explored longitudinal changes in cortisol…
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Association Between Visit-to-Visit Blood Pressure Variability and Incidence of Atrial Fibrillation in Hypertensive Patients: A Post-Hoc Analysis of the SPRINT Trial
Visit-to-visit blood pressure variability (BPV) has been recognized as a cardiovascular risk factor, but its association with new-onset atrial fibrillation (AF) remains underexplored. This study investigated the relationship between BPV and AF incidence among hypertensive patients using data from the Systolic Blood Pressure Intervention Trial (SPRINT). Visit-to-visit BPV was quantified using standard deviation (SD), coefficient…
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The effect of game-based scenario writing on the clinical reasoning of internship nursing students in cardiovascular emergencies and critical care units
CONCLUSIONS: The current study’s findings support the argument that the gamified scenario-writing method can be an effective and dynamic learning method. It appears that employing this approach in nursing education could potentially enhance the CR of nursing students during their internship courses. Therefore, applying this method is recommended to nursing educators, especially for cardiac emergencies…
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«It gives me the strength and courage to take care of myself»: a qualitative exploration of experiences with STI testing among women who initiated PrEP during pregnancy in Western Kenya
CONCLUSIONS: In this qualitative evaluation among women who initiated PrEP in pregnancy, STI testing encouraged PrEP use, even when results were negative. Incorporating STI testing within PrEP delivery in antenatal care represents an opportunity for addressing HIV/STI in this priority population.
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Clinical Efficacy of Acupuncture Therapy Based on the Principles of Primary Point Selection, Local Point Selection, and Syndrome Differentiation in Rheumatoid Arthritis
CONCLUSION: Acupuncture treatment based on primary point selection, local point selection, and syndrome differentiation significantly alleviates clinical symptoms and inflammatory states in patients with RA, thereby improving quality of life.
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Between-Visit Asthma Symptom Monitoring With a Scalable Digital Intervention: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of a scalable symptom monitoring intervention, the increase in asthma-related quality of life did not reach the threshold for a minimally important change. Exploratory analyses suggest possible benefits for patients with low levels of activation.