Clinical Trials
Category Added in a WPeMatico Campaign
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Comparing the Costs of Surveillance of Early-Stage Breast Cancer by Digital or Traditional Follow-Up Methods: Randomized Crossover Study
CONCLUSIONS: We did not find any statistically significant differences in the total cost of follow-up of EBC by digital solution or phone calls. The number of visits and costs were higher during the latter follow-up period, probably due to the scheduled routine 1-year visit. There were more visits and higher costs in the digital solution…
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Effectiveness and Safety of Omidenepag Isopropyl 0.002% Ophthalmic Solution in Treatment-Naive Patients With Primary Open Angle Glaucoma: A Prospective Multicenter Phase IV Study
CONCLUSION: Omidenepag isopropyl 0.002% ophthalmic solution is suitable for first-line use at first diagnosis of POAG, including in patients with NTG.
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Community engagement in early childhood development intervention trials: lessons learnt from a stepping stones program in rural India
CONCLUSION: Structured, participatory community engagement was critical to the successful implementation and impact of the Stepping Stones Program. The program evolved from a top-down intervention to a community-driven platform for nurturing care. Findings support the utility of an adaptive engagement framework in building equitable, sustainable, and scalable ECD interventions in low-resource settings.
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Artificial intelligence-enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial
CONCLUSION: The MedQuest mobile application significantly improved workflow efficiency and demonstrated strong concordance between AI- and clinician-assigned ICF mappings. These findings support the feasibility of integrating AI-assisted tools into routine clinical documentation. A hybrid model, combining AI automation with clinician oversight, may enhance accuracy and reduce documentation burden in time-constrained healthcare environments.
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The efficacy of lactobacillus reuteri in conjunction with racecadotril in managing pediatric rotavirus enteritis and its impact on intestinal mucosa and immune function
CONCLUSIONS: Combining Lactobacillus reuteri and racecadotril in treating pediatric rotavirus enteritis demonstrated efficacy in regulating intestinal microbiota, alleviating mucosal barrier dysfunction, improving immune function, and enhancing treatment effectiveness.
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Reduced opioids after total joint replacement surgery (REPAIRS): a pilot randomized controlled trial
CONCLUSIONS: This pilot trial indicated that a full-scale trial would be feasible and acceptable. Such a trial could provide evidence of comparative effectiveness for the reduced opioid regimen in this population.
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Long COVID Optimal Health Programme to Enhance Mental and Physical Health: A Feasibility Randomised Controlled Trial
CONCLUSION: Findings support the feasibility of delivering the LC-OHP to people with LC. Further, initial data demonstrate potential for the programme to improve most outcomes at three and 6 months. Data from this feasibility trial will be used as an evidence base to support a fully powered RCT of the LC-OHP on patients with LC.
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Evaluating the effect of a smartphone-based self-help intervention on the quality of life of patients with acute coronary syndrome
CONCLUSION: The results of this study indicated that a smartphone-based self-help intervention effectively improved the quality of life of patients with ACS. Nurse managers and clinical nurses can utilize these findings to increase the quality of life of patients.
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Long-Term Outcomes After Fractional Flow Reserve vs Intravascular Ultrasound to Guide PCI: The FLAVOUR Trial Extended Follow-Up
CONCLUSIONS: FFR-guided and IVUS-guided treatment strategies resulted in comparable long-term outcomes, with no significant difference in patient-oriented composite outcomes. Although FFR-guided treatment was associated with a higher incidence of late target vessel revascularization, the overall target vessel PCI rate, accounting for both the index procedure and revascularization during follow-up, remained significantly lower in the FFR-guided…
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Statin Use in Patients With Advanced Prostate Cancer in the TITAN and SPARTAN Trials
CONCLUSIONS AND RELEVANCE: In this cohort study, statin exposure was associated with longer OS in patients treated with apalutamide. Statin-exposed patients had a higher risk of grade 3 or greater cardiac AEs, which may reflect their preexisting cardiovascular comorbidity.